Arantxa González
YOU?
Author Swipe
View article: Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens
Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens Open
Cardiac fibrosis is mediated by the persistent activity of myofibroblasts, which differentiates from resident cardiac fibroblasts in response to tissue damage and stress signals. The signaling pathways and transcription factors regulating …
View article: Cardiac fibroblasts in myocardial injury and heart failure
Cardiac fibroblasts in myocardial injury and heart failure Open
Cardiac fibrosis is a major contributor to the development and progression of heart failure. It involves an aberrant deposition of extracellular matrix components, leading to impaired mechanical and electrical function of the heart. Despit…
View article: Nuclear auxin signalling induces autophagy for developmental reprogramming
Nuclear auxin signalling induces autophagy for developmental reprogramming Open
The phytohormone auxin is a central regulator of plant growth and development, traditionally known for mediating transcriptional reprogramming through the canonical TIR1/AFB-Aux/IAA signalling pathway. In this study, we reveal that auxin r…
View article: The Role of the BMPR2 Pathway in Group-II Pulmonary Hypertension Secondary to Valve Heart Disease
The Role of the BMPR2 Pathway in Group-II Pulmonary Hypertension Secondary to Valve Heart Disease Open
View article: Myocardial remodelling in aortic regurgitation: time to think beyond volumes and function?
Myocardial remodelling in aortic regurgitation: time to think beyond volumes and function? Open
Current guideline criteria for surgical intervention in chronic aortic regurgitation (AR) rely on fixed thresholds of left ventricular size and ejection fraction, but these metrics may overlook early myocardial injury and under-appreciate …
View article: Modulating Effect of Carbohydrate Antigen 125 on the Prognostic Value of High-Sensitivity C-Reactive Protein in Heart Failure
Modulating Effect of Carbohydrate Antigen 125 on the Prognostic Value of High-Sensitivity C-Reactive Protein in Heart Failure Open
Inflammation and congestion are key pathophysiological processes in heart failure (HF). Our aim was to evaluate the potential modulatory effect of carbohydrate antigen 125 (CA125) on inflammation, assessed by high-sensitivity C-reactive pr…
View article: Metabolic profiling and longitudinal changes in patients with severe aortic stenosis undergoing valve replacement
Metabolic profiling and longitudinal changes in patients with severe aortic stenosis undergoing valve replacement Open
Aims In patients with aortic stenosis (AS), the relation of cardiac energetic pathways with cardiac structure and function, their changes, and their prognostic significance are not well understood. We aimed to characterise metabolic profil…
View article: The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement
The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement Open
Cardiac remodeling involves myocardial hypertrophy and fibrosis which impairs cardiac function and, ultimately, contributes to heart failure (HF) and mortality. Fibrosis largely develops due to excessive matrix deposition and lysyl oxidase…
View article: The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the <scp>ESC</scp>
The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the <span>ESC</span> Open
A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation…
View article: Heart failure and obesity: Translational approaches and therapeutic perspectives. A scientific statement of the Heart Failure Association of the <scp>ESC</scp>
Heart failure and obesity: Translational approaches and therapeutic perspectives. A scientific statement of the Heart Failure Association of the <span>ESC</span> Open
Obesity and heart failure (HF) represent two growing pandemics. In the general population, obesity affects one in eight adults and is linked with an increased risk for HF. Obesity is even more common in patients with HF, where it complicat…
View article: Two concurrent mechanisms are responsible for the INa increase produced by dapagliflozin and empagliflozin in healthy and heart failure cardiomyocytes
Two concurrent mechanisms are responsible for the INa increase produced by dapagliflozin and empagliflozin in healthy and heart failure cardiomyocytes Open
Dapagliflozin and empagliflozin exert many cardiovascular protective actions in heart failure (HF) patients. HF-induced electrical remodelling decreases the expression of Nav1.5 channels (encoded by SCN5A) that generate the cardiac Na…
View article: Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (<scp>HFA</scp>) of the <scp>ESC</scp>, the <scp>ESC</scp> Council of Cardio‐Oncology, and the <scp>ESC</scp> Working Group on Cellular Biology of the Heart
Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (<span>HFA</span>) of the <span>ESC</span>, the <span>ESC</span> Council of Cardio‐Oncology, and the <span>ESC</span> Working Group on Cellular Biology of the Heart Open
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxici…
View article: Echocardiographic and biomarker characteristics in diabetes, coronary artery disease or both: insights from HOMAGE trial
Echocardiographic and biomarker characteristics in diabetes, coronary artery disease or both: insights from HOMAGE trial Open
Among HOMAGE trial participants, diabetes was a powerful driver of biomarker and echocardiographic alterations irrespectively of CAD. These alterations were mainly related to the domains of inflammation and diastolic function.
View article: Circulating collagen type I fragments as specific biomarkers of cardiovascular outcome risk: Where are the opportunities?
Circulating collagen type I fragments as specific biomarkers of cardiovascular outcome risk: Where are the opportunities? Open
View article: Determinants of reverse remodeling in chronic severe aortic regurgitation: Role of myocardial hypertrophy and extracellular volume
Determinants of reverse remodeling in chronic severe aortic regurgitation: Role of myocardial hypertrophy and extracellular volume Open
View article: State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the <scp>ESC</scp>, the <scp>ESC</scp> Council on Cardiovascular Genomics and the <scp>ESC</scp> Working Group on Myocardial & Pericardial Diseases
State of the art and perspectives of gene therapy in heart failure. A scientific statement of the Heart Failure Association of the <span>ESC</span>, the <span>ESC</span> Council on Cardiovascular Genomics and the <span>ESC</span> Working Group on Myocardial & Pericardial Diseases Open
Gene therapy has recently become a reality in the treatment of cardiovascular diseases. Strategies to modulate gene expression using antisense oligonucleotides or small interfering RNA are proving to be safe and effective in the clinic. Ad…
View article: Proteomic biomarkers and pathway analysis for progression to heart failure in three epidemiological representative cohorts
Proteomic biomarkers and pathway analysis for progression to heart failure in three epidemiological representative cohorts Open
Aims Biomarkers associated with asymptomatic ventricular dysfunction might improve risk stratification and identify pathways leading to heart failure (HF). We explored the association between proteomic biomarkers and left ventricular hyper…
View article: Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial
Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial Open
View article: High variability in assays of blood markers of collagen turnover in cardiovascular disease: Implications for research and clinical practice
High variability in assays of blood markers of collagen turnover in cardiovascular disease: Implications for research and clinical practice Open
Aims Fibrosis is a common feature of many chronic diseases, including heart failure, which can have deleterious effects on cardiac structure and function that are associated with adverse outcomes. By‐products of collagen synthesis and degr…
View article: The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases
The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases Open
Fibrosis, driven by fibroblast activities, is an important contributor to morbidity and mortality in most chronic diseases. Endotrophin, a signaling molecule derived from processing of type VI collagen by highly activated fibroblasts, is i…
View article: Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial
Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial Open
Objective Heart failure (HF) is characterised by collagen deposition. Urinary proteomic profiling (UPP) followed by peptide sequencing identifies parental proteins, for over 70% derived from collagens. This study aimed to refine understand…
View article: Transcriptomic Analysis of Extracellular Vesicles in the Search for Novel Plasma and Thrombus Biomarkers of Ischemic Stroke Etiologies
Transcriptomic Analysis of Extracellular Vesicles in the Search for Novel Plasma and Thrombus Biomarkers of Ischemic Stroke Etiologies Open
Accurate etiologic diagnosis provides an appropriate secondary prevention and better prognosis in ischemic stroke (IS) patients; still, 45% of IS are cryptogenic, urging us to enhance diagnostic precision. We have studied the transcriptomi…
View article: Proteomic profiles of left atrial volume and its influence on response to spironolactone: Findings from the HOMAGE trial and STANISLAS cohort
Proteomic profiles of left atrial volume and its influence on response to spironolactone: Findings from the HOMAGE trial and STANISLAS cohort Open
Aims High left ventricular filling pressure increases left atrial volume and causes myocardial fibrosis, which may decrease with spironolactone. We studied clinical and proteomic characteristics associated with left atrial volume indexed b…
View article: Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the <scp>Heart Failure Association</scp> (<scp>HFA</scp>) and <scp>European Heart Rhythm Association</scp> (<scp>EHRA</scp>) of the <scp>European Society of Cardiology</scp> (<scp>ESC</scp>)
Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the <span>Heart Failure Association</span> (<span>HFA</span>) and <span>European Heart Rhythm Association</span> (<span>EHRA</span>) of the <span>European Society of Cardiology</span> (<span>ESC</span>) Open
Implantable devices form an integral part of the management of patients with heart failure (HF) and provide adjunctive therapies in addition to cornerstone drug treatment. Although the number of these devices is growing, only few are suppo…
View article: Myocardial perfusion in cardiac amyloidosis
Myocardial perfusion in cardiac amyloidosis Open
Aims Cardiac involvement is the main driver of clinical outcomes in systemic amyloidosis and preliminary studies support the hypothesis that myocardial ischaemia contributes to cellular damage. The aims of this study were to assess the pre…
View article: Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays
Generation of Self-Induced Myocardial Ischemia in Large-Sized Cardiac Spheroids without Alteration of Environmental Conditions Recreates Fibrotic Remodeling and Tissue Stiffening Revealed by Constriction Assays Open
A combination of human-induced pluripotent stem cells (hiPSCs) and 3D microtissue culture techniques allows the generation of models that recapitulate the cardiac microenvironment for preclinical research of new treatments. In particular, …
View article: Biomarkers of Collagen Metabolism Are Associated with Left Ventricular Function and Prognosis in Dilated Cardiomyopathy: A Multi-Modal Study
Biomarkers of Collagen Metabolism Are Associated with Left Ventricular Function and Prognosis in Dilated Cardiomyopathy: A Multi-Modal Study Open
Background: Collagen cross-linking is a fundamental process in dilated cardiomyopathy (DCM) and occurs when collagen deposition exceeds degradation, leading to impaired prognosis. This study investigated the associations of collagen-metabo…
View article: Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies <i>FIXER</i> , a Conserved Profibrogenic Long Noncoding RNA
Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies <i>FIXER</i> , a Conserved Profibrogenic Long Noncoding RNA Open
BACKGROUND: Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation and interstitial fibrosis. Fibrosis is associated with …
View article: Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies
Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies Open
Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis, resulting from the excessive deposition of collagen fibers, is a common feature across the spectrum of conditions converging in heart failure. E…
View article: Mortality and severe neurological morbidity in extremely preterm growth‐restricted fetuses
Mortality and severe neurological morbidity in extremely preterm growth‐restricted fetuses Open
Objective To develop a model for the prediction of adverse perinatal outcome in growth‐restricted fetuses requiring delivery before 28 weeks in order to provide individualized patient counseling. Methods This was a retrospective multicente…