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View article: Author response: Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer
Author response: Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer Open
View article: Leishmania amazonensis impairs phagosome acidification in B-1 phagocytes as an unrecognized parasite infection and proliferation mechanism
Leishmania amazonensis impairs phagosome acidification in B-1 phagocytes as an unrecognized parasite infection and proliferation mechanism Open
Leishmaniasis is a neglected disease affecting people from tropical and subtropical areas. It is caused by protozoan parasites called Leishmania and transmitted by sandflies during blood meal. In phagocytic cells such as macrophages, L. am…
View article: Matrix Metalloproteinases as Candidate Antigenic Determinants for Anti‐Tumor Autoantibodies in Human Ovarian Cancer: A Post Hoc Analysis
Matrix Metalloproteinases as Candidate Antigenic Determinants for Anti‐Tumor Autoantibodies in Human Ovarian Cancer: A Post Hoc Analysis Open
Circulating antibodies in patients with cancer can facilitate the identification of accessible epitopes on autoantigens expressed by tumors. To identify previously unrecognized protein targets in ovarian cancer, we computationally assessed…
View article: Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer
Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer Open
Background Human gastric cancer remains a diagnostic and therapeutic challenge worldwide. Improved prognostic biomarkers may support treatment planning, including surgery, neoadjuvant and adjuvant therapies. We offer a new liquid biopsy ap…
View article: Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer
Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer Open
Background Human gastric cancer remains a diagnostic and therapeutic challenge worldwide. Improved prognostic biomarkers may support treatment planning, including surgery, neoadjuvant and adjuvant therapies. We offer a new liquid biopsy ap…
View article: None: Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer
None: Endoscopic liquid biopsies of gastric fluid in a large patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer Open
View article: Correction: Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor
Correction: Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor Open
View article: Human nerve growth factor delivery to the retina: Quantitative methodology and mathematical modeling in preclinical settings
Human nerve growth factor delivery to the retina: Quantitative methodology and mathematical modeling in preclinical settings Open
Nerve growth factor (NGF) plays a critical neuroprotective role in retinal health, supporting neuronal survival and regeneration. Recombinant human NGF (rhNGF) holds promise for treating retinal degenerative diseases such as glaucoma, reti…
View article: Rethinking Gleason 6 Prostate Cancer: Embracing PrNLMP for Precision and Progress
Rethinking Gleason 6 Prostate Cancer: Embracing PrNLMP for Precision and Progress Open
View article: First-generation and preclinical evaluation of an EphA5-targeted antibody-drug conjugate in solid tumors
First-generation and preclinical evaluation of an EphA5-targeted antibody-drug conjugate in solid tumors Open
Contemporary cancer treatment strategies are shifting toward targeted therapies to improve efficacy and minimize toxicity. Here, we report the design and preclinical evaluation of MBRC-101, a first-in-class antibody-drug conjugate (ADC) ta…
View article: Conformational ligand-directed targeting of calcium-dependent receptors in acute trauma
Conformational ligand-directed targeting of calcium-dependent receptors in acute trauma Open
View article: Identification of Symptom Profiles in Prostate Cancer Survivors
Identification of Symptom Profiles in Prostate Cancer Survivors Open
Prostate cancer survivors experience varying degrees of symptom severity. Understanding the symptom profiles and associated factors can inform nurses about patients in need of symptom management and targeted interventions.
View article: eLife Assessment: A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer
eLife Assessment: A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer Open
View article: High-throughput prediction of peptide structural conformations with AlphaFold2
High-throughput prediction of peptide structural conformations with AlphaFold2 Open
Protein structure prediction via artificial intelligence/machine learning (AI/ML) approaches has sparked substantial research interest in structural biology and adjacent disciplines. More recently, AlphaFold2 (AF2) has been adapted for the…
View article: eLife Assessment: A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer
eLife Assessment: A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer Open
View article: Generative artificial intelligence performs rudimentary structural biology modeling
Generative artificial intelligence performs rudimentary structural biology modeling Open
Natural language-based generative artificial intelligence (AI) has become increasingly prevalent in scientific research. Intriguingly, capabilities of generative pre-trained transformer (GPT) language models beyond the scope of natural lan…
View article: eLife Assessment: A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer
eLife Assessment: A Large-Scale Proteomics Resource of Circulating Extracellular Vesicles for Biomarker Discovery in Pancreatic Cancer Open
Pancreatic cancer has the worst prognosis of all common tumors. Earlier cancer diagnosis could increase survival rates and better assessment of metastatic disease could improve patient care. As such, there is an urgent need to develop biom…
View article: Preclinical optimization of a diode laser-based clamp-free partial nephrectomy in a large animal model
Preclinical optimization of a diode laser-based clamp-free partial nephrectomy in a large animal model Open
Kidney cancer is a common urologic malignancy with either laparoscopic (LPN) or robotic partial nephrectomy as therapeutic options of choice for localized tumors. However, renal resection and suturing are challenging steps of the procedure…
View article: Supplemental Figure Legends from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens
Supplemental Figure Legends from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens Open
Supplemental Figure Legends
View article: Data from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78
Data from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78 Open
Purpose: The major cause of morbidity in breast cancer is development of metastatic disease, for which few effective therapies exist. Because tumor cell dissemination is often an early event in breast cancer progression and can occu…
View article: Supplementary Figure 3 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78
Supplementary Figure 3 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78 Open
PDF file - 159K, Supplementary Figure 3. BMTP78 kills breast cell lines in a GRP78-dependent manner.
View article: Supplementary Figure 1 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78
Supplementary Figure 1 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78 Open
PDF file - 735K, Supplementary Figure 1. Details of the analysis of cell surface GRP78 levels using flow cytometry.
View article: Supplementary Figure 5 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78
Supplementary Figure 5 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78 Open
PDF file - 425K, Supplementary Figure 5. Body weights of mice bearing 4T1.2 mammary tumors during treatment with BMTP78 or control peptide or saline.
View article: Supplementary Figure 3 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78
Supplementary Figure 3 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78 Open
PDF file - 159K, Supplementary Figure 3. BMTP78 kills breast cell lines in a GRP78-dependent manner.
View article: Supplemental Table 1 from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens
Supplemental Table 1 from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens Open
Supplemental Table 1. Features of synthesized analogs of BMTP-11 for drug-lead optimization.
View article: Supplemental Figure Legends from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens
Supplemental Figure Legends from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens Open
Supplemental Figure Legends
View article: Supplementary Figure 1 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78
Supplementary Figure 1 from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78 Open
PDF file - 735K, Supplementary Figure 1. Details of the analysis of cell surface GRP78 levels using flow cytometry.
View article: Data from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78
Data from Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface–Associated GRP78 Open
Purpose: The major cause of morbidity in breast cancer is development of metastatic disease, for which few effective therapies exist. Because tumor cell dissemination is often an early event in breast cancer progression and can occu…
View article: Data from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens
Data from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens Open
Purpose: The IL11 receptor (IL11R) is an established molecular target in primary tumors of bone, such as osteosarcoma, and in secondary bone metastases from solid tumors, such as prostate cancer. However, its potential role in manag…
View article: Supplemental Figure 2 from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens
Supplemental Figure 2 from Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens Open
Supplemental Figure 2. Cell membrane and cytoplasmic expression of IL-11R.