Arash Arashkia
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View article: Efficient Delivery of CRISPR-Cas9 RNP Complexes with Cyclodextrin-Based Nanosponges for Enhanced Genome Editing: TILD-CRISPR Integration
Efficient Delivery of CRISPR-Cas9 RNP Complexes with Cyclodextrin-Based Nanosponges for Enhanced Genome Editing: TILD-CRISPR Integration Open
The CRISPR-Cas9 system has transformed biomedical research by enabling precise genetic modifications. However, efficient delivery of CRISPR components remains a major hurdle for therapeutic applications. To address this, we employed a new …
View article: Expression of the switch receptor PD1/IL15Rβ in MSLN-CAR-T cells overcomes PD1/PDL1 signaling in solid tumors
Expression of the switch receptor PD1/IL15Rβ in MSLN-CAR-T cells overcomes PD1/PDL1 signaling in solid tumors Open
Background The immunosuppressive tumor microenvironment (TME) limits the efficacy of chimeric antigen receptor (CAR) T cells in solid tumors by inducing T-cell exhaustion through inhibitory receptors, such as PD-1 and TIM-3. T memory stem …
View article: Novel bioinformatics approaches to design epitope-based vaccine against HIV latency by inquiring CTL epitopes and built-in adjuvants
Novel bioinformatics approaches to design epitope-based vaccine against HIV latency by inquiring CTL epitopes and built-in adjuvants Open
A key characteristic of HIV-1 persistence under antiretroviral therapy is its ability to form a latent reservoir in T cells, creating an obstacle to the virus eradication, therefore, there is no effective and permanent treatment against HI…
View article: The Antitumor Effect of a Non-Transforming E7 Protein Combined with a TLR7 Agonist
The Antitumor Effect of a Non-Transforming E7 Protein Combined with a TLR7 Agonist Open
Despite great efforts in developing peptide-based therapeutic vaccines against human papillomavirus (HPV)-induced cervical cancers, they have failed to elicit strong and sustainable immune responses. Here, we evaluated the vaccine potentia…
View article: Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA
Central position of histidine in the sequence of designed alternating polarity peptides enhances pH-responsive assembly with DNA Open
View article: Expression and functional characterization of an anti-CD22 scFv targeting B-cell malignancies
Expression and functional characterization of an anti-CD22 scFv targeting B-cell malignancies Open
Background and purpose: Single-chain variable fragments (scFvs) offer advantages over full-length monoclonal antibodies in cancer therapy, including reduced size, lower production costs, and easier handling. However, Escherichia coli (E. c…
View article: Expression of the Switch Receptor Pd1/Il15rβ in Msln-Car-T Cells Overcomes Pd1/Pdl1 Signaling in Solid Tumors
Expression of the Switch Receptor Pd1/Il15rβ in Msln-Car-T Cells Overcomes Pd1/Pdl1 Signaling in Solid Tumors Open
View article: In silico studies of green fluorescent protein-tagged Hsp27-HPV16 E7 fusion protein and evaluation of cytokine secretion from antigen-presenting cells exposed to the fusion protein-carrying tumor-derived exosomes
In silico studies of green fluorescent protein-tagged Hsp27-HPV16 E7 fusion protein and evaluation of cytokine secretion from antigen-presenting cells exposed to the fusion protein-carrying tumor-derived exosomes Open
Objective: Exosome (Exo)-based therapies have attracted considerable interest due to their potential as carriers for therapeutic molecules and their capacity to elicit anti-tumor immune responses. The objective of this study was to enginee…
View article: The first case of Mpox infection in Iran during the 2022 outbreak
The first case of Mpox infection in Iran during the 2022 outbreak Open
Introduction: The unexpected outbreak of human Mpox infection beginning in some European countries that were non-endemic for Mpox stunned the world during the Coronavirus Disease 2019 (COVID-19) pandemic in May 2022. The re-emerging Mpox o…
View article: Type-specific human papillomavirus prevalence in women referred for colposcopy in Tehran
Type-specific human papillomavirus prevalence in women referred for colposcopy in Tehran Open
Background and Objectives: Although several studies have been achieved on the frequency of the HPV types among wom- en with cervical cancer in Iran, HPV-positive samples were in some cases directed to specific-primer genotyping of HPV 16 a…
View article: Investigating the Effects of HMGB1 Overexpression on Colorectal Cancer Cell Migration via Oncolytic Herpes simplex Virus Type 1 (oHSV-1)
Investigating the Effects of HMGB1 Overexpression on Colorectal Cancer Cell Migration via Oncolytic Herpes simplex Virus Type 1 (oHSV-1) Open
Background: Colorectal Cancer (CRC) represents a significant global health challenge, and its progression, resistance to therapy, and metastasis are strongly influenced by the tumor microenvironment, including factors like hypoxia. This st…
View article: Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell
Tuning spacer length improves the functionality of the nanobody-based VEGFR2 CAR T cell Open
View article: Nona-Arginine Mediated Anti-E6 ShRNA Delivery Suppresses the Growth of Hela Cells in vitro
Nona-Arginine Mediated Anti-E6 ShRNA Delivery Suppresses the Growth of Hela Cells in vitro Open
The study suggests that R9 is a promising non-viral gene carrier for transfecting E6 shRNA in vitro, with significant transfection efficiency and minimal toxicity.
View article: Alum and a TLR7 agonist combined with built-in TLR4 and 5 agonists synergistically enhance immune responses against HPV RG1 epitope
Alum and a TLR7 agonist combined with built-in TLR4 and 5 agonists synergistically enhance immune responses against HPV RG1 epitope Open
View article: In silico Identification of Hypoxic Signature followed by reverse transcription-quantitative PCR Validation in Cancer Cell Lines
In silico Identification of Hypoxic Signature followed by reverse transcription-quantitative PCR Validation in Cancer Cell Lines Open
The identified protein-protein interaction network of common DEGs could serve as potential hypoxia biomarkers and might be helpful for improving therapeutic strategies.
View article: Fiber manipulation and post-assembly nanobody conjugation for adenoviral vector retargeting through SpyTag-SpyCatcher protein ligation
Fiber manipulation and post-assembly nanobody conjugation for adenoviral vector retargeting through SpyTag-SpyCatcher protein ligation Open
For adenoviruses (Ads) to be optimally effective in cancer theranostics, they need to be retargeted toward target cells and lose their natural tropism. Typically, this is accomplished by either engineering fiber proteins and/or employing b…
View article: Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand?
Modifying oncolytic virotherapy to overcome the barrier of the hypoxic tumor microenvironment. Where do we stand? Open
View article: Immunovirotherapy: The role of antibody based therapeutics combination with oncolytic viruses
Immunovirotherapy: The role of antibody based therapeutics combination with oncolytic viruses Open
Despite the fact that the new drugs and targeted therapies have been approved for cancer therapy during the past 30 years, the majority of cancer types are still remain challenging to be treated. Due to the tumor heterogeneity, immune syst…
View article: Packaging, Purification, and Titration of Replication-Deficient Semliki Forest Virus-Derived Particles as a Self-Amplifying mRNA Vaccine Vector
Packaging, Purification, and Titration of Replication-Deficient Semliki Forest Virus-Derived Particles as a Self-Amplifying mRNA Vaccine Vector Open
Using optimized methods for SAM transfection, VRP packaging, and concentration, high yields of SFV-PD VRPs could be produced and purified. The RT-qPCR demonstrated to be an accurate and rapid method for titer determination of replication d…
View article: Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses
Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses Open
Flaviviruses are arthropod-borne viruses (arboviruses) that have been recently considered among the significant public health problems in defined geographical regions. In this line, there have been vaccines approved for some flaviviruses i…
View article: Cell type-specific response of colon cancer tumor cell lines to oncolytic HSV-1 virotherapy in hypoxia
Cell type-specific response of colon cancer tumor cell lines to oncolytic HSV-1 virotherapy in hypoxia Open
Background Novel strategies are required since the hypoxic tumor microenvironment is one of the important impediments for conventional cancer therapy. High mobility group box 1 (HMGB1) protein can block aerobic respiration in cancer cells.…
View article: Immunoinformatics Approach for Designing an HPV Epitope-Based Vaccine Candidate Harboring Built-in Adjuvants
Immunoinformatics Approach for Designing an HPV Epitope-Based Vaccine Candidate Harboring Built-in Adjuvants Open
Immunoinformatics Approach for Designing an HPV Epitope-Based Vaccine Candidate Harboring Built-in Adjuvants
View article: The evolving direct and indirect platforms for the detection of SARS-CoV-2
The evolving direct and indirect platforms for the detection of SARS-CoV-2 Open
View article: Corrigendum to ‘How Iran responded to expanding need for laboratory services for COVID-19?’
Corrigendum to ‘How Iran responded to expanding need for laboratory services for COVID-19?’ Open
View article: Lineage analysis of human papillomavirus type 39 in cervical samples of Iranian women
Lineage analysis of human papillomavirus type 39 in cervical samples of Iranian women Open
View article: Ebola as a case study for the patent landscape of medical countermeasures for emerging infectious diseases
Ebola as a case study for the patent landscape of medical countermeasures for emerging infectious diseases Open
View article: How Iran responded to expanding need for laboratory services for COVID-19?
How Iran responded to expanding need for laboratory services for COVID-19? Open
View article: The Inclusive Review on SARS-CoV-2 Biology, Epidemiology, Diagnosis, and Potential Management Options
The Inclusive Review on SARS-CoV-2 Biology, Epidemiology, Diagnosis, and Potential Management Options Open
View article: Virus against virus: strategies for using adenovirus vectors in the treatment of HPV-induced cervical cancer
Virus against virus: strategies for using adenovirus vectors in the treatment of HPV-induced cervical cancer Open
View article: Co‐administration of 2’3’-cGAMP STING activator and CpG-C adjuvants with a mutated form of HPV 16 E7 protein leads to tumor growth inhibition in the mouse model
Co‐administration of 2’3’-cGAMP STING activator and CpG-C adjuvants with a mutated form of HPV 16 E7 protein leads to tumor growth inhibition in the mouse model Open