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View article: Orthogonal spectral and temporal envelope representation during the onset phase in auditory cortex
Orthogonal spectral and temporal envelope representation during the onset phase in auditory cortex Open
Speech perception relies on two fundamental acoustic components: spectral and temporal. While spectral information is known to be represented in the auditory cortex through tonotopy, how temporal features are organized has remained unclear…
View article: Case Report: Improved hearing in a rare, adult IDH2-mutant brainstem astrocytoma successfully treated with radiation and temozolomide
Case Report: Improved hearing in a rare, adult IDH2-mutant brainstem astrocytoma successfully treated with radiation and temozolomide Open
Introduction Brain stem gliomas harboring IDH mutations can be sensitive to temozolomide (TMZ) treatment, unlike their H3K27-altered counterparts, so distinguishing the two is essential. Case presentation Here, we report an adult brainstem…
View article: Parathyroid near-infrared autofluorescence differently benefits depending on the surgeon’s skill for preventing from hypoparathyroidism after total thyroidectomy: A systematic review and meta-analysis
Parathyroid near-infrared autofluorescence differently benefits depending on the surgeon’s skill for preventing from hypoparathyroidism after total thyroidectomy: A systematic review and meta-analysis Open
Objective To evaluate the role of parathyroid near-infrared autofluorescence in reducing the incidence of postoperative hypocalcemia and hypoparathyroidism after total thyroidectomy, and to determine which surgeons benefit most from parath…
View article: Long-term outcomes of pharmacotherapy in patients with persistent postural-perceptual dizziness
Long-term outcomes of pharmacotherapy in patients with persistent postural-perceptual dizziness Open
Introduction Persistent postural-perceptual dizziness (PPPD) is a chronic neuro-otologic disorder characterized by vestibular symptoms such as dizziness, unsteadiness, or non-spinning vertigo. Its pathophysiology is presumed to involve sen…
View article: Orthogonal spectral and temporal envelope representation in auditory cortex
Orthogonal spectral and temporal envelope representation in auditory cortex Open
Speech perception relies on two fundamental acoustic components: spectral and temporal. While spectral information is known to be represented in the auditory cortex through tonotopy, how temporal features are organized has remained unclear…
View article: Comparative study of Cognitive-Behavioral Therapy with Pharmacotherapy for Persistent Postural-Perceptual Dizziness: A Pilot Study
Comparative study of Cognitive-Behavioral Therapy with Pharmacotherapy for Persistent Postural-Perceptual Dizziness: A Pilot Study Open
We conducted a non-randomized, open-label, parallel-group study on patients with persistent postural-perceptual dizziness (PPPD) to compare cognitive-behavioral therapy ([CBT] group, n = 20) received a 6-session CBT program with pharmacoth…
View article: Clinical features of persistent postural-perceptual dizziness coexisting with Meniere’s disease in comparison with Meniere’s disease alone
Clinical features of persistent postural-perceptual dizziness coexisting with Meniere’s disease in comparison with Meniere’s disease alone Open
Background Persistent postural-perceptual dizziness (PPPD) is a chronic vestibular syndrome often triggered by acute or episodic vestibular syndromes, such as Meniere’s disease (MD). According to the diagnostic criteria, PPPD may coexist w…
View article: Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma
Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma Open
Background In view of improving biomarkers predicting the efficacy of immunotherapy for head and neck squamous cell carcinoma (R/M HNSCC), this multicenter retrospective study aimed to identify clinical, tumor microenvironmental, and genom…
View article: Second Career Attitudes of Otolaryngology Physicians in Japan
Second Career Attitudes of Otolaryngology Physicians in Japan Open
勤務医不足や医師偏在の解消にベテラン医師の活躍が期待されており, 耳鼻咽喉科頭頸部外科学会専門医育成・活用ワーキンググループでは, 学会主導のシニアドクターバンクを計画している. 今回, その基盤情報となるベテラン医師のセカンドキャリアに関する意識を調査するため, 2023年1月時点で40歳以上の会員を対象として, アンケート調査を行った. 開業医598人, 勤務医705人から回答を得た. 開業医では, 26%に閉院予定があり, そのうち57%は希望が合えば再就職したいと考…
View article: A Case of Eosinophilic Sinusitis with Eosinophilic Granulomatosis with Polyangiitis during Treatment with Dupilumab
A Case of Eosinophilic Sinusitis with Eosinophilic Granulomatosis with Polyangiitis during Treatment with Dupilumab Open
好酸球性副鼻腔炎(eosinophilic chronic rhinosinusitis: ECRS)はtype2炎症が関与する難治性の副鼻腔炎である。近年,type2炎症を抑制する生物学的製剤が開発され,抗IL-4/13受容体抗体であるdupilumabが鼻茸を伴う慢性副鼻腔炎に対して適応となっている。dupilumabのECRSに対する効果は高く安全性も高いとされているが,時に重篤な副反応を呈することがある。今回われわれはECRSに対してdupilumab投与中に好酸球…
View article: P546 Endoscopic findings related to the long-term response to anti-TNF-α antibody treatment in patients with Crohn's disease
P546 Endoscopic findings related to the long-term response to anti-TNF-α antibody treatment in patients with Crohn's disease Open
Background Anti-TNF-α antibody treatment in Crohn's disease patients has been established, but loss of treatment response has become a problem in recent years. No studies have investigated the endoscopic findings related to loss of respons…
View article: Role of eosinophilia in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab: Prediction of immune‐related adverse events and favorable outcome
Role of eosinophilia in patients with recurrent/metastatic head and neck squamous cell carcinoma treated with nivolumab: Prediction of immune‐related adverse events and favorable outcome Open
Introduction Immune‐related adverse events (irAEs) are prognostic factors for patients on nivolumab. However, predictors of irAEs have not yet been identified. We aimed to investigate the predictors of irAEs occurrence and nivolumab discon…
View article: Two Cases of Posterior Glottic Stenosis Treated with Different Surgical Approaches
Two Cases of Posterior Glottic Stenosis Treated with Different Surgical Approaches Open
後部声門狭窄症は外傷や炎症によって声門後部が癒着する疾患である. 症例1は44歳女性. 声帯突起部の橋状癒着を認め, 後部声門狭窄症 (声帯突起部の癒着) と診断した. 直達喉頭鏡下に癒着を切離した. 症例2は61歳男性. 両側声帯麻痺と診断され気管切開術を受けた. 気管切開孔から観察すると, 声門後部の橋状癒着と右の輪状披裂関節周囲粘膜の線維化があり, 左輪状披裂関節周囲粘膜には軽度の線維化を認め, 後部声門狭窄症 (片側の輪状披裂関節強直を伴う後交連狭窄) と診断した.…