Dhiraj Tripathi
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View article: Clinical Trial: A Multicentre Randomised Controlled Trial of Carvedilol Versus Variceal Band Ligation in Primary Prevention of Variceal Bleeding in Liver Cirrhosis (<scp>CALIBRE</scp> Trial)
Clinical Trial: A Multicentre Randomised Controlled Trial of Carvedilol Versus Variceal Band Ligation in Primary Prevention of Variceal Bleeding in Liver Cirrhosis (<span>CALIBRE</span> Trial) Open
Background The superior efficacy of non‐selective beta‐blockers (NSBB) compared with variceal band ligation (VBL) in the primary prevention of variceal bleeding is uncertain. Aim To compare carvedilol versus VBL for primary prevention of v…
View article: “A COMPARATIVE EVALUATION OF PROSEAL LMA AND ENDOTRACHEAL TUBE IN PATIENTS UNDERGOING ELECTIVE LAPAROSCOPIC SURGERY UNDER GENERAL ANAESTHESIA”
“A COMPARATIVE EVALUATION OF PROSEAL LMA AND ENDOTRACHEAL TUBE IN PATIENTS UNDERGOING ELECTIVE LAPAROSCOPIC SURGERY UNDER GENERAL ANAESTHESIA” Open
View article: A Clinical Study Comparing Postoperative Shoulder Pain Between Low and Standard Pressure Pneumoperitoneum in Laparoscopic Cholecystectomy: A Randomized Trial
A Clinical Study Comparing Postoperative Shoulder Pain Between Low and Standard Pressure Pneumoperitoneum in Laparoscopic Cholecystectomy: A Randomized Trial Open
View article: Porto-sinusoidal vascular liver disorder with portal hypertension: Natural history and long-term outcome
Porto-sinusoidal vascular liver disorder with portal hypertension: Natural history and long-term outcome Open
View article: Portal vein thrombosis: diagnosis, management, and endpoints for future clinical studies
Portal vein thrombosis: diagnosis, management, and endpoints for future clinical studies Open
View article: Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial Open
Background Liver disease is within the top five causes of premature death in adults. Deaths caused by complications of cirrhosis continue to rise, whilst deaths related to other non-liver disease areas are declining. Portal hypertension is…
View article: Study protocol for a Randomised controlled trial of EArly transjugular intrahepatiC porTosystemic stent–shunt in Acute Variceal Bleeding (REACT-AVB trial)
Study protocol for a Randomised controlled trial of EArly transjugular intrahepatiC porTosystemic stent–shunt in Acute Variceal Bleeding (REACT-AVB trial) Open
Introduction In liver cirrhosis, acute variceal bleeding (AVB) is associated with a 1-year mortality rate of up to 40%. Data on early or pre-emptive transjugular intrahepatic portosystemic stent–shunt (TIPSS) in AVB is inconclusive and may…
View article: A Multicentre Randomised Controlled Trial of Carvedilol Versus Variceal Band Ligation in Primary Prevention of Variceal Bleeding in Liver Cirrhosis (CALIBRE Trial)
A Multicentre Randomised Controlled Trial of Carvedilol Versus Variceal Band Ligation in Primary Prevention of Variceal Bleeding in Liver Cirrhosis (CALIBRE Trial) Open
View article: Predicting and optimising risks for non-hepatic surgery in patients with cirrhosis: insights from the #FGDebate
Predicting and optimising risks for non-hepatic surgery in patients with cirrhosis: insights from the #FGDebate Open
View article: Technical and clinical outcomes following EUS-guided thrombin injection and coil implantation for parastomal varices
Technical and clinical outcomes following EUS-guided thrombin injection and coil implantation for parastomal varices Open
Background and aims Bleeding from parastomal varices causes significant morbidity and mortality. Treatment options are limited, particularly in high-risk patients with significant underlying liver disease and other comorbidities. The use o…
View article: British Society of Gastroenterology Best Practice Guidance: outpatient management of cirrhosis – part 1: compensated cirrhosis
British Society of Gastroenterology Best Practice Guidance: outpatient management of cirrhosis – part 1: compensated cirrhosis Open
The prevalence of cirrhosis has risen significantly over recent decades and is predicted to rise further. Widespread use of non-invasive testing means cirrhosis is increasingly diagnosed at an earlier stage. Despite this, there are signifi…
View article: British Society of Gastroenterology Best Practice Guidance: outpatient management of cirrhosis – part 2: decompensated cirrhosis
British Society of Gastroenterology Best Practice Guidance: outpatient management of cirrhosis – part 2: decompensated cirrhosis Open
There are two distinct phases in the natural history of cirrhosis: compensated disease (corresponding to Child Pugh A and early Child Pugh B disease), where the patient may be largely asymptomatic, progressing with increasing portal hypert…
View article: British Society of Gastroenterology Best Practice Guidance: outpatient management of cirrhosis – part 3: special circumstances
British Society of Gastroenterology Best Practice Guidance: outpatient management of cirrhosis – part 3: special circumstances Open
The prevalence of cirrhosis has risen significantly over recent decades and is predicted to rise further. Widespread use of non-invasive testing means cirrhosis is increasingly diagnosed at an earlier stage. Despite this, there are signifi…
View article: Carvedilol, probably the β‐blocker of choice for everyone with cirrhosis and portal hypertension: But not so fast!
Carvedilol, probably the β‐blocker of choice for everyone with cirrhosis and portal hypertension: But not so fast! Open
Non-selective β-blockers (NSBBs) are the mainstay long-term therapy for portal hypertension. Numerous randomized-controlled trials and observational studies have established their therapeutic benefit in patients with cirrhosis.1 The effica…
View article: Guidance document: risk assessment of patients with cirrhosis prior to elective non-hepatic surgery
Guidance document: risk assessment of patients with cirrhosis prior to elective non-hepatic surgery Open
As a result of the increasing incidence of cirrhosis in the UK, more patients with chronic liver disease are being considered for elective non-hepatic surgery. A historical reluctance to offer surgery to such patients stems from general pe…
View article: Reply to: “Carvedilol in patients with compensated cirrhosis: The ongoing benefits of definitive randomised trials over meta-analysis in patients with small varices”
Reply to: “Carvedilol in patients with compensated cirrhosis: The ongoing benefits of definitive randomised trials over meta-analysis in patients with small varices” Open
View article: Letter: improve survival in variceal bleeding in cirrhosis—place <scp>pTIPS</scp> as early as possible after index bleed. Authorsʼ reply
Letter: improve survival in variceal bleeding in cirrhosis—place <span>pTIPS</span> as early as possible after index bleed. Authorsʼ reply Open
LINKED CONTENT This article is linked to Dunne et al papers. To view these articles, visit https://doi.org/10.1111/apt.17252 and https://doi.org/10.1111/apt.17322
View article: Cirrhosis and non-hepatic surgery in 2023 – a precision medicine approach
Cirrhosis and non-hepatic surgery in 2023 – a precision medicine approach Open
Robust preoperative, individually tailored, and precise risk assessment can reduce peri- and postoperative complications in patients with cirrhosis. Established prognostic scores aid stratification, providing an estimation of postoperative…
View article: Liver Transplantation for Porto-sinusoidal Vascular Liver Disorder: Long-term Outcome
Liver Transplantation for Porto-sinusoidal Vascular Liver Disorder: Long-term Outcome Open
Background. Porto-sinusoidal vascular liver disorder (PSVD) is a rare disease that occasionally requires liver transplantation (LT), despite usually presenting preserved liver function. There remains a paucity of data pertaining to LT in P…
View article: Covered transjugular intrahepatic portosystemic stent-shunt <i>vs</i> large volume paracentesis in patients with cirrhosis: A real-world propensity score-matched study
Covered transjugular intrahepatic portosystemic stent-shunt <i>vs</i> large volume paracentesis in patients with cirrhosis: A real-world propensity score-matched study Open
Covered TIPSS results in similar TFS compared to LVP in cirrhotic patients with advanced liver failure. Liver transplant assessment should be considered in all potential candidates for TIPSS. Further controlled studies are recommended to s…
View article: Evaluation of CirrhoCare® – a digital health solution for home management of individuals with cirrhosis
Evaluation of CirrhoCare® – a digital health solution for home management of individuals with cirrhosis Open
View article: Letter: non‐selective beta‐blockers in cirrhosis—effect beyond portal hypertension. Authors' reply
Letter: non‐selective beta‐blockers in cirrhosis—effect beyond portal hypertension. Authors' reply Open
LINKED CONTENT This article is linked to Dunne et al papers. To view these articles, visit https://doi.org/10.1111/apt.16901 and https://doi.org/10.1111/apt.16941
View article: Corrigendum to ‘Baveno VII – Renewing consensus in portal hypertension’ [J Hepatol (2022) 959-974]
Corrigendum to ‘Baveno VII – Renewing consensus in portal hypertension’ [J Hepatol (2022) 959-974] Open
View article: Baveno VII – Renewing consensus in portal hypertension
Baveno VII – Renewing consensus in portal hypertension Open
View article: Role of early transjugular intrahepatic portosystemic stent-shunt in acute variceal bleeding: An update of the evidence and future directions
Role of early transjugular intrahepatic portosystemic stent-shunt in acute variceal bleeding: An update of the evidence and future directions Open
Variceal bleeding is a serious complication of cirrhosis and portal hypertension. Despite the improvement in management of acute variceal bleed (AVB), it still carries significant mortality. Portal pressure is the main driver of variceal b…
View article: OWE-5 Carvedilol vs. endoscopic band ligation for variceal bleeding secondary prophylaxis; long-term RCT follow-up
OWE-5 Carvedilol vs. endoscopic band ligation for variceal bleeding secondary prophylaxis; long-term RCT follow-up Open
Introduction Carvedilol reduces rates of variceal bleeding and rebleeding by lowering portal pressure. However, an associated pleotropic survival benefit has been proposed. We aim to investigate further by undertaking long-term follow-up o…
View article: OWE-3 Timing of pre-emptive TIPS does not alter patient outcome, a UK multicentre study
OWE-3 Timing of pre-emptive TIPS does not alter patient outcome, a UK multicentre study Open
Introduction International guidelines suggest consideration of pre-emptive transjugular intrahepatic portosystemic shunt (pTIPS) within 72h of endoscopic haemostasis following acute oesophageal variceal bleeding (OVB) in 'high-risk' patien…
View article: P046 Liver re-transplantation in adults; a single UK centre experience (2009–2020)
P046 Liver re-transplantation in adults; a single UK centre experience (2009–2020) Open
Liver transplantation is a life -saving modality for liver failure. Graft failure occurs in 5–22% of all liver transplant recipients.1–6 Liver re-transplantation has been considered controversial, with clinical, economic, and e…
View article: Exploring patients’ perceptions and experiences of treatments for the prevention of variceal bleeding: a qualitative study
Exploring patients’ perceptions and experiences of treatments for the prevention of variceal bleeding: a qualitative study Open
Background The most common fatal complication of liver cirrhosis is haemorrhaging caused by variceal rupture. The prevention of the first variceal bleed is, therefore, an important clinical goal. Little is known about patients’ experience …
View article: Economic evaluation of covered stents for transjugular intrahepatic portosystemic stent shunt in patients with variceal bleeding and refractory ascites secondary to cirrhosis
Economic evaluation of covered stents for transjugular intrahepatic portosystemic stent shunt in patients with variceal bleeding and refractory ascites secondary to cirrhosis Open
Objectives Transjugular intrahepatic portosystemic stent shunt (TIPSS) is clinically effective in variceal bleeding and refractory ascites; however, the cost-effectiveness of TIPSS has yet to be evaluated in the UK. This study aimed to est…