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View article: Precision cardiovascular medicine: shifting the innovation paradigm
Precision cardiovascular medicine: shifting the innovation paradigm Open
Despite the development of potent drugs for modifiable risk factors and advances in mechanistic biomedical research, cardiovascular diseases (CVDs) collectively remain the leading cause of death globally, indicating a need for new, more ef…
View article: Interactive Effects of Maternal Vitamin D Binding Protein and Vitamin D on Offspring Asthma
Interactive Effects of Maternal Vitamin D Binding Protein and Vitamin D on Offspring Asthma Open
Rationale Vitamin-D-binding-protein transports vitamin-D metabolites and regulates vitamin-D levels in circulation. Additionally, maternal vitamin-D levels during pregnancy plays an important role in lung development and childhood asthma o…
View article: Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals
Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals Open
The coronavirus disease (COVID-19) pandemic has occurred in Massachusetts in multiple waves led by a series of emerging variants. While the evidence has linked obesity with severe symptoms of COVID-19, the effect of obesity on susceptibili…
View article: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (Litonjua and Weiss, 2007). Vitamin D supplementation studies do not provide insig…
View article: Author Response: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Author Response: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (). Vitamin D supplementation studies do not provide insight into the molecular ge…
View article: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (1). Vitamin D supplementation studies do not provide insight into the molecular g…
View article: Reviewer #2 (Public Review): Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Reviewer #2 (Public Review): Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (). Vitamin D supplementation studies do not provide insight into the molecular ge…
View article: Reviewer #1 (Public Review): Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Reviewer #1 (Public Review): Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (). Vitamin D supplementation studies do not provide insight into the molecular ge…
View article: Author Response: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Author Response: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (). Vitamin D supplementation studies do not provide insight into the molecular ge…
View article: Reviewer #1 (Public Review): Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Reviewer #1 (Public Review): Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (). Vitamin D supplementation studies do not provide insight into the molecular ge…
View article: Reviewer #2 (Public Review): Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Reviewer #2 (Public Review): Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (). Vitamin D supplementation studies do not provide insight into the molecular ge…
View article: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (1). Vitamin D supplementation studies do not provide insight into the molecular g…
View article: Detecting and dissecting signaling crosstalk via the multilayer network integration of signaling and regulatory interactions
Detecting and dissecting signaling crosstalk via the multilayer network integration of signaling and regulatory interactions Open
The versatility of cellular response arises from the communication, or crosstalk, of signaling pathways in a complex network of signaling and transcriptional regulatory interactions. Understanding the various mechanisms underlying crosstal…
View article: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (1). Vitamin D supplementation studies do not provide insight into the molecular g…
View article: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (Litonjua and Weiss, 2007). Vitamin D supplementation studies do not provide insig…
View article: Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis
Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis Open
BACKGROUND: Fewer than 50% of patients who develop aortic valve calcification have concomitant atherosclerosis, implying differential pathogenesis. Although circulating extracellular vesicles (EVs) act as biomarkers of cardiovascular disea…
View article: Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity Open
Aims Calcific aortic valve disease (CAVD) is the most common valve disease, which consists of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pat…
View article: Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery
Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery Open
Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activit…
View article: Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms
Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms Open
Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase subtilisin/kexin 9) increases low-density l…
View article: Detecting and dissecting signaling crosstalk via the multilayer network integration of signaling and regulatory interactions
Detecting and dissecting signaling crosstalk via the multilayer network integration of signaling and regulatory interactions Open
The versatility of cellular response arises from the communication, or crosstalk, of signaling pathways in a complex network of signaling and transcriptional regulatory interactions. Understanding the various mechanisms underlying crosstal…
View article: Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology
Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology Open
Background Abdominal aortic aneurysm (AAA), characterized by a continued expansion of the aorta, leads to rupture if not surgically repaired. Mice aid the study of disease progression and its underlying mechanisms since sequential studies …
View article: Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1 Open
Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (1). Vitamin D supplementation studies do not provide insight into the molecular g…
View article: Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development Open
Background: Vein graft failure remains a common clinical challenge. We applied a systems approach in mouse experiments to discover therapeutic targets for vein graft failure. Methods: Global proteomics and high-dimensional clustering on mu…
View article: Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion Open
Aims Proteostasis maintains protein homeostasis and participates in regulating critical cardiometabolic disease risk factors including proprotein convertase subtilisin/kexin type 9 (PCSK9). Endoplasmic reticulum (ER) remodeling through rel…
View article: Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative virus for the current global pandemic known as coronavirus disease 2019 (COVID-19). SARS-CoV-2 belongs to the family of single-stranded RNA viruses known as coro…
View article: ApoC-III is a novel inducer of calcification in human aortic valves
ApoC-III is a novel inducer of calcification in human aortic valves Open
Calcific aortic valve disease (CAVD) occurs when subpopulations of valve cells undergo specific differentiation pathways, promoting tissue fibrosis and calcification. Lipoprotein particles carry oxidized lipids that promote valvular diseas…
View article: CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction
CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction Open
Objective: Vascular calcification is a critical pathology associated with increased cardiovascular event risk, but there are no Food and Drug Administration-approved anticalcific therapies. We hypothesized and validated that an unbiased sc…