Arghavan Ashja Ardalan
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View article: Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy
Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy Open
Colorectal cancer (CRC) remains one of the most prevalent and lethal cancers worldwide, prompting ongoing research into innovative therapeutic strategies. This review aims to systematically evaluate the role of gelatinases, specifically MM…
View article: Shaping the Landscape of Lung Cancer: The Role and Therapeutic Potential of Matrix Metalloproteinases
Shaping the Landscape of Lung Cancer: The Role and Therapeutic Potential of Matrix Metalloproteinases Open
Lung cancer is a leading cause of cancer-related mortality worldwide, characterized by its aggressive nature and poor prognosis. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, play a pivotal role in the progre…
View article: Tumor Suppression by PD-1/PD-L1 Interaction Blockage in Mice Model
Tumor Suppression by PD-1/PD-L1 Interaction Blockage in Mice Model Open
Background: Overexpression of programmed cell death ligand 1 (PD-L1) in tumor cells and subsequent interaction with the programmed cell death protein 1 (PD-1) in tumor-infiltrating T cells cause an immune evasion of the tumor from cytotoxi…
View article: Development of polyclonal heavy chain antibodies targeting programmed death ligand-1.
Development of polyclonal heavy chain antibodies targeting programmed death ligand-1. Open
Programmed death ligand-1 (PD-L1, CD274 and B7-H1) has been described as a ligand for immune inhibitory receptor programmed death protein 1 (PD-1). With binding to PD-1 on activated T cells, PD-L1 can prevent T cell responses via motivatin…