Ari Chaouat
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Altered static respiratory compliance under invasive mechanical ventilation in SARS-CoV-2 infection in the development of respiratory sequelae Open
CRS value on the first day of invasive mechanical ventilation was not associated with the risk of developing respiratory sequelae. However, attention should be paid to age, ventilator-associated pneumonia and CRS evolution, to detect patie…
<i>Ad Integrum</i> respiratory recovery after pneumonia caused by <i>Mycoplasma pneumoniae</i> in adult patients Open
Long-term evolution of Mycoplasma pneumoniae pneumonia revealed ad integrum recovery of pulmonary lesions and normalisation of pulmonary function in all patients. Peripheral deconditioning was frequent and should be systematically evaluate…
Prognostic value of right ventricular myocardial work in patients with pulmonary arterial hypertension Open
Background Right ventricular function is a key determinant of survival in patients with pulmonary arterial hypertension, with right heart failure being the leading cause of death. ESC/ERS guidelines recommend evaluating RV function at diag…
Pulmonary hypertension in patients with chronic obstructive pulmonary disease: Impact of lung hyperinflation on the response to pulmonary hypertension treatment Open
The study design has been registered on ClinicalTrials (NCT06613321).
A longitudinal study of right ventricular function of patients with multiple myeloma treated with carfilzomib Open
A particular focus on right ventricular function should be suggested in patients during treatment with carfilzomib due to potential RV side-effects. TAPSE follow-up appears to be an interesting tool for close monitoring of these patients. …
View article: Pulmonary hypertension associated with COPD: a phenotype analysis
Pulmonary hypertension associated with COPD: a phenotype analysis Open
Background Pulmonary hypertension (PH) associated with COPD (PH-COPD) exhibits diverse phenotypes, challenging therapeutic management. This study aimed to describe the characteristics of COPD patients with distinct phenotypes, namely end-s…
View article: Risk stratification refinements with inclusion of haemodynamic variables at follow-up in patients with pulmonary arterial hypertension
Risk stratification refinements with inclusion of haemodynamic variables at follow-up in patients with pulmonary arterial hypertension Open
Background Haemodynamic variables are prognostic factors in pulmonary arterial hypertension (PAH). However, right heart catheterisation (RHC) is not systematically recommended to assess the risk status during follow-up. This study aimed to…
Long‐term follow‐up of neutrophil activation after severe‐to‐critical <span>SARS‐CoV</span>‐2 infection: A longitudinal study Open
International audience
Case report: Extracorporeal life support as a successful bridge to recovery in an incident case of pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance (PVR) due to vascular remodeling of the small pulmonary arteries. In advanced RV failure or severe hypoxemia, extra corporeal…
View article: Outcomes and risk assessment in pulmonary veno-occlusive disease
Outcomes and risk assessment in pulmonary veno-occlusive disease Open
Introduction Pulmonary veno-occlusive disease (PVOD) is a rare and severe subtype of pulmonary arterial hypertension (PAH). Although European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines advise assessing PAH seve…
An emerging phenotype of pulmonary arterial hypertension patients carrying<i>SOX17</i>variants Open
Background The phenotype of pulmonary arterial hypertension (PAH) patients carrying SOX17 pathogenic variants remains mostly unknown. Methods We report the genetic analysis findings, characteristics and outcomes of patients with heritable …
Magnetic resonance imaging in pulmonary hypertension: an overview of current applications and future perspectives Open
Pulmonary hypertension is an heterogeneous group of diseases characterised by increased pulmonary arterial pressures which impact on the upstream right ventricle. Pulmonary hypertension can be challenging to diagnose, classify and monitor …
View article: External validation of a refined four-stratum risk assessment score from the French pulmonary hypertension registry
External validation of a refined four-stratum risk assessment score from the French pulmonary hypertension registry Open
Introduction Contemporary risk assessment tools categorise patients with pulmonary arterial hypertension (PAH) as low, intermediate or high risk. A minority of patients achieve low risk status with most remaining intermediate risk. Our aim…
View article: Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension
Association between Initial Treatment Strategy and Long-Term Survival in Pulmonary Arterial Hypertension Open
Rationale: The relationship between the initial treatment strategy and survival in pulmonary arterial hypertension (PAH) remains uncertain. Objectives: To evaluate the long-term survival of patients with PAH categorized according to the in…
Severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A prospective French multicenter cohort Open
Severe PH-COPD is characterized by moderate airway obstruction but marked dyspnea and marked hypoxemia, low DLCO and high mPAP. This phenotype is associated with poor prognosis.
Outcomes of patients with decreased arterial oxyhaemoglobin saturation on pulmonary arterial hypertension drugs Open
Background Drugs approved for the treatment of pulmonary arterial hypertension (PAH) improve long-term outcomes. These drugs have pulmonary vasodilator properties which may potentially cause a decrease in arterial oxyhaemoglobin saturation…
View article: Serum and pulmonary uric acid in pulmonary arterial hypertension
Serum and pulmonary uric acid in pulmonary arterial hypertension Open
Previous studies have suggested an association between uric acid (UA) and the severity of pulmonary arterial hypertension (PAH), but it is unknown whether UA contributes to disease pathogenesis. The aim of this study was to determine the p…
Sleep-related breathing disorders and pulmonary hypertension Open
Sleep-related breathing disorders (SBDs) include obstructive apnoea, central apnoea and sleep-related hypoventilation. These nocturnal events have the potential to increase pulmonary arterial pressure (PAP) during sleep but also in the wak…
Phenotype and outcome of pulmonary arterial hypertension patients carrying a<i>TBX4</i>mutation Open
Introduction TBX4 mutation causes small patella syndrome (SPS) and/or pulmonary arterial hypertension (PAH). The characteristics and outcomes of PAH associated with TBX4 mutations are largely unknown. Methods We report the clinical, functi…
Supplementary Material for: Exercise Hemodynamics in the Prognosis of Patients with Pulmonary Arterial Hypertension Open
Background: Assessment of prognosis is of major importance when deciding on a therapeutic strategy in patients with pulmonary arterial hypertension (PAH). Objectives: The aim of this study was to investigate the prognostic value of pulmona…
View article: Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial
Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial Open
Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.Objectives: To evaluate the effect of oral treprostinil compared with placebo o…
View article: Clinical phenotypes and outcomes of precapillary pulmonary hypertension of sickle cell disease
Clinical phenotypes and outcomes of precapillary pulmonary hypertension of sickle cell disease Open
Rationale Precapillary pulmonary hypertension (PH) is a devastating complication of sickle cell disease (SCD). Little is known about the influence of the SCD genotype on PH characteristics. Objectives To describe clinical phenotypes and ou…