Explanipedia

Abstract 2788 Chemokine Switching via ARF6-AMAP1: A Key Mechanism of Immune Evasion in Pancreatic Cancer Open

Ari Hashimoto, Haruka Handa, Daisuke Okuzaki, Tsukasa Oikawa, Yoshihiro Nishikawa , et al. · 2025

Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives Open

Ari Hashimoto, Shigeru Hashimoto · 2024

Cancer has long been believed to be a genetic disease caused by the accumulation of mutations in key genes involved in cellular processes. However, recent advances in sequencing technology have demonstrated that cells with cancer driver mu…

MitoNEET reduces the mitochondrial oxidative phosphorylation during epithelial-mesenchymal transition Open

Haruka Handa, Yasuhito Onodera, Tsukasa Oikawa, Shingo Takada, Koji Ueda , et al. · 2024

Mitochondrial functions range from catabolic to anabolic, which are tightly coordinated to meet cellular demands for proliferation and motility. MitoNEET is a mitochondrial outer membrane protein with a CDGSH domain and is involved in mito…

p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus Open

Tsukasa Oikawa, Junya Hasegawa, Haruka Handa, Naomi Ohnishi, Yasuhito Onodera , et al. · 2024

H3.1 histone is predominantly synthesized and enters the nucleus during the G1/S phase of the cell cycle, as a new component of duplicating nucleosomes. Here, we found that p53 is necessary to secure the normal behavior and modification of…

Correction to: Computer model of IL-6-dependent rheumatoid arthritis in F759 mice Open

Reiji Yamamoto, Satoshi Yamada, Toru Atsumi, Kaoru Murakami, Ari Hashimoto , et al. · 2024

ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity Open

Ari Hashimoto, Shigeru Hashimoto · 2023

Despite the “big data” on cancer from recent breakthroughs in high-throughput technology and the development of new therapeutic modalities, it remains unclear as to how intra-tumor heterogeneity and phenotypic plasticity created by various…

p53 secures the normal behavior of H3.1 histone in the nucleus by regulating nuclear phosphatidic acid and EZH2 during the G1/S phase Open

Tsukasa Oikawa, Junya Hasegawa, Haruka Handa, Naomi Ohnishi, Yasuhito Onodera , et al. · 2023

Histones are key molecules of epigenetic regulation and inheritance, and are thought to be chaperoned and transported into the nucleus appropriately prior to being integrated into nucleosomes. H3.1 histone is predominantly synthesized and …

Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open

Gyanu Parajuli, Murat Tekgüç, James B. Wing, Ari Hashimoto, Daisuke Okuzaki , et al. · 2023

The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5…

Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open

Gyanu Parajuli, Murat Tekgüç, James B. Wing, Ari Hashimoto, Daisuke Okuzaki , et al. · 2023

Supplementary Figures 1-8 and Tables 1-3

Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open

Gyanu Parajuli, Murat Tekgüç, James B. Wing, Ari Hashimoto, Daisuke Okuzaki , et al. · 2023

The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5…

Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open

Gyanu Parajuli, Murat Tekgüç, James B. Wing, Ari Hashimoto, Daisuke Okuzaki , et al. · 2023

Supplementary Figures 1-8 and Tables 1-3

A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling Open

Taiga Maemoto, Yuichi Kitai, Runa Takahashi, Haruka Shoji, Shunsuke Yamada , et al. · 2022

Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma Open

Ari Hashimoto, Haruka Handa, Soichiro Hata, Shigeru Hashimoto · 2022

Pancreatic ductal adenocarcinoma (PDAC) is the most fatal cancer in humans, due to its difficulty of early detection and its high metastatic ability. The occurrence of epithelial to mesenchymal transition in preinvasive pancreatic lesions …

Tumor-derived interleukin-34 creates an immunosuppressive and chemoresistant tumor microenvironment by modulating myeloid-derived suppressor cells in triple-negative breast cancer Open

Nabeel Kajihara, Takuto Kobayashi, Ryo Otsuka, Junko Nio‐Kobayashi, Tomohiro Oshino , et al. · 2022

Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance Open

Shigeru Hashimoto, Ari Hashimoto, Ryuta Muromoto, Yuichi Kitai, Kenji Oritani , et al. · 2022

Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-associated inflammation contributes to tumor initiation and progression. However, it remains unclear whether a collapse of the balance between the ant…

ARF6-AMAP1 pathway induces pancreatic cancer cells to express immunosuppressive chemokines Open

Ari Hashimoto, Haruka Handa, Soichiro Hata, Daisuke Okuzaki, Yoshizuki Fumoto , et al. · 2022

Aim: The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) is highly immune suppressive with modest T-cell infiltration, and only rarely responds to immune checkpoint inhibition (ICI) therapy. Our aim was to clarify t…

Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open

Gyanu Parajuli, Murat Tekgüç, James B. Wing, Ari Hashimoto, Daisuke Okuzaki , et al. · 2021

The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5…

Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer Open

Ari Hashimoto, Haruka Handa, Soichiro Hata, Akio Tsutaho, Takao Yoshida , et al. · 2021

High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer Open

Akio Tsutaho, Ari Hashimoto, Shigeru Hashimoto, Soichiro Hata, Shion Kachi , et al. · 2020

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer Open

Shigeru Hashimoto, Shotaro Furukawa, Ari Hashimoto, Akio Tsutaho, Akira Fukao , et al. · 2019

Significance Pancreatic ductal carcinomas (PDACs) have been extensively studied regarding their genomic alterations, microenvironmental intercommunication, and metabolic reprogramming. However, identification of the protein machinery of tu…

Endothelin type B receptor interacts with the 78‐kDa glucose‐regulated protein Open

Yuichi Mazaki, Tsunehito Higashi, Yasuhito Onodera, Jin‐Min Nam, Ari Hashimoto , et al. · 2019

Endothelin ( ET )‐1 is involved in the vascular system, cell proliferation and apoptosis. ET receptors consist of ET type A receptor ( ET A R ) and ET type B receptor ( ET B R ). ET A R and ET B R generally exhibit opposite responses, alth…

GRP78 promotes ERK activation through endothelin type B receptor Open

Yuichi Mazaki, Tsunehito Higashi, Yasuhito Onodera, Jin‐Min Nam, Ari Hashimoto , et al. · 2019

Endothelin (ET)-1 is involved in various diseases, including cancer, hypertension, atherosclerosis, diabetes, and fibrotic diseases, although ET-1 is originally identified as endothelium-derived vasocontractile peptide. ET receptors belong…

Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells Open

Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa , et al. · 2018

Histone modifications of certain miRNA loci, such as the miR-183-96-182 cistron, are different between epithelial cells and non-epithelial cells. Such epithelial-specific miRNA regulation appears to provide the molecular basis for the epit…

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model Open

Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, Shigeru Hashimoto, Haruka Handa , et al. · 2018

Additional file 2: of Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells Open

Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa , et al. · 2018

Figure S2. Epigenome status of each miRNA. The ENCODE data of miRNAs in Fig. 2a are shown by the UCSC Genome Browser. Definitions of the colors are given at the top of Fig. 3c. (ZIP 21369â kb)

High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue Open

Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera, Jin‐Min Nam , et al. · 2016

Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells Open

Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hisataka Sabe · 2016

Modes of cancer invasion interchange between the mesenchymal type and amoeboid type in response to the microenvironment, in which RhoA and Rac1 are selectively required to perform different modes of actin-cytoskeletal remodeling. Membrane …

ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance Open

Ari Hashimoto, Shigeru Hashimoto, Hiroaki Sugino, A. Yoshikawa, Yasuhito Onodera , et al. · 2016

Tumor responsiveness to statins requires overexpression of the ARF6 pathway Open

Hisataka Sabe, Ari Hashimoto, Shigeru Hashimoto, Tsukasa Oikawa · 2016

The mevalonate pathway results in the prenylation of small GTPases, which are pivotal for oncogenesis and cancer malignancies. However, inhibitors of this pathway, such as statins, have not necessarily produced favorable results in clinica…

P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance Open

Ari Hashimoto, Tsukasa Oikawa, Shigeru Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa , et al. · 2016

Drug resistance, metastasis, and a mesenchymal transcriptional program are central features of aggressive breast tumors. The GTPase Arf6, often overexpressed in tumors, is critical to promote epithelial–mesenchymal transition and invasiven…

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