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View article: Night-to-night variability in Apnoea-Hypopnoea Index: Implications for Obstructive Sleep Apnoea diagnosis
Night-to-night variability in Apnoea-Hypopnoea Index: Implications for Obstructive Sleep Apnoea diagnosis Open
View article: New-onset atrial fibrillation in patients with acute hypercapnic respiratory failure requiring non-invasive ventilation
New-onset atrial fibrillation in patients with acute hypercapnic respiratory failure requiring non-invasive ventilation Open
Introduction Atrial fibrillation (AF) and chronic obstructive lung disease (COPD) are the most common cardiac arrythmia and chronic lung condition worldwide. Exacerbations of COPD can be associated with acute hypercapnic respiratory failur…
View article: Exploring Ai-Bot In An Esl Filipino Flipped Classroom: A Sequential Mixed-Methods Study
Exploring Ai-Bot In An Esl Filipino Flipped Classroom: A Sequential Mixed-Methods Study Open
Artificial intelligence (AI) is increasingly influencing English as a Second Language (ESL) education for Filipino students. This study investigates the effectiveness of Chai, an AI-powered chatbot, integrated into a flipped classroom mode…
View article: Clinical and epidemiological characteristics of patients with persistent COVID in Mexico
Clinical and epidemiological characteristics of patients with persistent COVID in Mexico Open
View article: Resuscitation and Initial Management After Moderate-to-Severe Traumatic Brain Injury: Questions for the On-Call Shift
Resuscitation and Initial Management After Moderate-to-Severe Traumatic Brain Injury: Questions for the On-Call Shift Open
Traumatic brain injury (TBI) is a leading cause of disability and mortality globally, stemming from both primary mechanical injuries and subsequent secondary responses. Effective early management of moderate-to-severe TBI is essential to p…
View article: The use of venous blood gas in assessing arterial acid−base and oxygenation status – an analysis of aggregated data from multiple studies evaluating the venous to arterial conversion (v-TAC) method
The use of venous blood gas in assessing arterial acid−base and oxygenation status – an analysis of aggregated data from multiple studies evaluating the venous to arterial conversion (v-TAC) method Open
These data suggest that v-TAC analysis may have a role in replacing ABGs, avoiding arterial puncture. Substantial data exist in patients with chronic hypercapnia and chronic base excess, acute hyper- and hypocapnia, and in patients with re…
View article: S102 Cardiac arrhythmogenesis in sleep apnoea (CAOS): a prospective multi-centre study
S102 Cardiac arrhythmogenesis in sleep apnoea (CAOS): a prospective multi-centre study Open
Background Sleep disordered breathing (SDB) is associated with an increased risk of cardiac arrhythmias. There is compelling evidence showing a bi-directional relationship between atrial fibrillation (AF) and obstructive sleep apnoea (OSA)…
View article: Pharmacological Management of Allergic Rhinitis: A Consensus Statement from the Malaysian Society of Allergy and Immunology
Pharmacological Management of Allergic Rhinitis: A Consensus Statement from the Malaysian Society of Allergy and Immunology Open
The goal of allergic rhinitis (AR) management is to achieve satisfactory symptom control to ensure good quality of life. Most patients with AR are currently treated with pharmacotherapy. However, knowledge gaps on the use of pharmacotherap…
View article: Exploring the impact of excessive daytime sleepiness caused by obstructive sleep apnea on patient and partner quality of life: a time trade-off utility study in the UK general public
Exploring the impact of excessive daytime sleepiness caused by obstructive sleep apnea on patient and partner quality of life: a time trade-off utility study in the UK general public Open
View article: Cerebrospinal fluid hydrothorax in a rehabilitation medicine patient following thoracotomy for thoracic disc protrusion
Cerebrospinal fluid hydrothorax in a rehabilitation medicine patient following thoracotomy for thoracic disc protrusion Open
Cerebrospinal fluid (CSF) hydrothorax has been reported most commonly as a complication of ventriculo-pleural/-peritoneal shunt insertion, but also due to duro-pleural fistula. Here we report a case of CSF hydrothorax in a rehabilitation p…
View article: Obstructive sleep apnoea and atrial fibrillation: a key omission in guidelines
Obstructive sleep apnoea and atrial fibrillation: a key omission in guidelines Open
Toolkit for commissioning and planning
View article: Markers of adipose tissue hypoxia are elevated in subcutaneous adipose tissue of severely obese patients with obesity hypoventilation syndrome but not in the moderately obese
Markers of adipose tissue hypoxia are elevated in subcutaneous adipose tissue of severely obese patients with obesity hypoventilation syndrome but not in the moderately obese Open
View article: The characterisation of sleep and circadian rhythm in neuromyelitis optica
The characterisation of sleep and circadian rhythm in neuromyelitis optica Open
Around a third of a human lifespan is spent in the essential life process of sleep. Disordered sleep is present in 15-35% of adults and is frequently underrecognized and underreported. Sleep disorders are associated with an elevated risk o…
View article: Post COVID-19 bronchiectasis: a potential epidemic within a pandemic
Post COVID-19 bronchiectasis: a potential epidemic within a pandemic Open
Novel coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and as of 29 May 2020 it has affected approximately 6 million people and caused 362 00...
View article: Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis
Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis Open
Novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has rapidly spread throughout the world, resulting in a pandemic with high mortality. There are no effective treatments for …
View article: Randomised, cOntrolled Multicentre trial of 26 weeks subcutaneous liraglutide (a glucagon-like peptide-1 receptor Agonist), with or without contiNuous positive airway pressure (CPAP), in patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnoEa (OSA) (ROMANCE): study protocol assessing the effects of weight loss on the apnea–hypnoea index (AHI)
Randomised, cOntrolled Multicentre trial of 26 weeks subcutaneous liraglutide (a glucagon-like peptide-1 receptor Agonist), with or without contiNuous positive airway pressure (CPAP), in patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnoEa (OSA) (ROMANCE): study protocol assessing the effects of weight loss on the apnea–hypnoea index (AHI) Open
Introduction Obstructive sleep apnoea (OSA) and type 2 diabetes mellitus (T2DM) often occur concurrently, and untreated OSA may potentially amplify the high risk of cardiovascular disease in T2DM. Compliance with continuous positive airway…
View article: COVID-19 cytokine storm: the interplay between inflammation and coagulation
COVID-19 cytokine storm: the interplay between inflammation and coagulation Open
View article: Does Coronavirus Disease 2019 Disprove the Obesity Paradox in Acute Respiratory Distress Syndrome?
Does Coronavirus Disease 2019 Disprove the Obesity Paradox in Acute Respiratory Distress Syndrome? Open
To the Editor: We are writing in reference to the editorial "COVID 19 and the Patient with Obesity – The Editors Speak Out" ((1)). Obesity is associated with a decrease in mortality in patients with acute respiratory distress syndrome (ARD…
View article: COVID-19 follow-up planning: what will we be missing?
COVID-19 follow-up planning: what will we be missing? Open
There is a real need for a discharge plan for COVID-19 survivors in the UK. Follow-up imaging could help assess the resolution of infection, exclude underlying malignancy and identify post-inflammatory fibrosis. https://bit.ly/2YJ8h…
View article: HNICEM 2018 Authors Index
HNICEM 2018 Authors Index Open
View article: Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients
Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients Open
In very obese individuals, our results indicate that increased volumes of upper airway structures are associated with increased severity of OSA, as previously reported in less obese individuals. Increasingly large upper airway structures t…
View article: P214 Remote monitoring in the early stages of continuous positive airway pressure (cpap) initiation in obstructive sleep apnoea (osa) allows early detection of poor compliance and mask problems
P214 Remote monitoring in the early stages of continuous positive airway pressure (cpap) initiation in obstructive sleep apnoea (osa) allows early detection of poor compliance and mask problems Open
Background OSA is an increasingly recognised disease and successfully treated with CPAP. There are ever increasing demands on sleep services in the UK, in terms of provision, compliance and safety. One possible solution is the use of remot…
View article: P126 Weaning outcomes of mechanically ventilated spinal cord injured persons with acute tetraplegia admitted to a regional uk centre over a 10 year period
P126 Weaning outcomes of mechanically ventilated spinal cord injured persons with acute tetraplegia admitted to a regional uk centre over a 10 year period Open
Introduction The occurrence of Spinal Cord Injury (SCI) is often complicated by the need for assisted ventilation. This study charts the weaning outcomes of mechanically ventilated SCI subjects admitted over a 10 year period to a regional …
View article: Obesity, respiratory disease and pulmonary infections
Obesity, respiratory disease and pulmonary infections Open
Obesity is one of the major epidemics of our time and its prevalence is only believed to increase over coming years. The detrimental effect of obesity on the risk of cardiovascular disease, diabetes and cancer has long been recognised and …
View article: Management of obstructive sleep apnoea syndrome
Management of obstructive sleep apnoea syndrome Open
Obstructive sleep apnoea (OSA) describes the pathological narrowing and collapse of the upper airway in recurrent episodes during sleep. This can result in a variety of symptoms that markedly affect quality of life. In addition, other chro…
View article: Exploratory study into the effect of abdominal mass loading on airways resistance and ventilatory failure
Exploratory study into the effect of abdominal mass loading on airways resistance and ventilatory failure Open
Objective We hypothesised that the airway resistance during tidal breathing would correlate with a particular pattern of increasing obesity, particularly when supine, and would differ between participants with and without ventilatory failu…
View article: Correlates of obesity-related chronic ventilatory failure
Correlates of obesity-related chronic ventilatory failure Open
Introduction Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure. Materials/patients and methods Participants had …
View article: Factors associated with ventilatory failure in obesity
Factors associated with ventilatory failure in obesity Open
INTRODUCTION: Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure. MATERIALS/PATIENTS AND METHODS: Participants ha…
View article: P109 Predicting difficult mechanical ventilation in obese patients undergoing laparoscopic surgery: An observational study
P109 Predicting difficult mechanical ventilation in obese patients undergoing laparoscopic surgery: An observational study Open
Introduction Morbid obesity and super obesity are associated with increasingly negative effects on respiratory parameters, but beyond BMI itself the physical predictors of difficult intraoperative ventilation have not been demonstrated. We…
View article: Biomarkers of oxidative stress following continuous positive airway pressure withdrawal: data from two randomised trials
Biomarkers of oxidative stress following continuous positive airway pressure withdrawal: data from two randomised trials Open
There is conflicting evidence whether intermittent hypoxia in obstructive sleep apnoea (OSA) influences oxidative stress. We hypothesised that withdrawal of continuous positive airway pressure (CPAP) from patients with OSA would raise mark…