Ariane Fillmer
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View article: Macromolecule Modelling for Improved Metabolite Quantification Using Short Echo Time Brain <sup>1</sup>H‐MRS at 3 T and 7 T: The PRaMM Model
Macromolecule Modelling for Improved Metabolite Quantification Using Short Echo Time Brain <sup>1</sup>H‐MRS at 3 T and 7 T: The PRaMM Model Open
To improve reliability of metabolite quantification at both, 3 T and 7 T, we propose a novel parametrized macromolecules quantification model (PRaMM) for brain 1 H MRS, in which the ratios of macromolecule peak intensities are used as soft…
View article: Plasma p‐tau181 and GFAP reflect 7T MR‐derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS
Plasma p‐tau181 and GFAP reflect 7T MR‐derived changes in Alzheimer's disease: A longitudinal study of structural and functional MRI and MRS Open
BACKGROUND Associations between longitudinal changes of plasma biomarkers and cerebral magnetic resonance (MR)‐derived measurements in Alzheimer's disease (AD) remain unclear. METHODS In a study population ( n = 127) of healthy older adult…
View article: Can construct specification equations help us progress the biomarker‐cognition debate in dementia?
Can construct specification equations help us progress the biomarker‐cognition debate in dementia? Open
Background Currently, there are no widely accepted causal models of how common biomarkers linked to dementia present as cognitive symptoms. In the current study, we present a methodology and preliminary findings to ascertain relations betw…
View article: Associations between blood‐based biomarkers and other outcomes related to Alzheimer’s disease
Associations between blood‐based biomarkers and other outcomes related to Alzheimer’s disease Open
Background Blood‐based biomarkers (BBM) have shown promising potential in diagnosis and prognosis of patients affected by Alzheimer’s disease (AD) pathology. This observational study analyzed the cross‐sectional relation between BBMs and d…
View article: Macromolecule modelling for improved metabolite quantification using short echo time brain<sup>1</sup>H MRS at 3 T and 7 T: The PRaMM Model
Macromolecule modelling for improved metabolite quantification using short echo time brain<sup>1</sup>H MRS at 3 T and 7 T: The PRaMM Model Open
Purpose To improve reliability of metabolite quantification at both, 3 T and 7 T, we propose a novel parametrized macromolecules quantification model (PRaMM) for brain 1 H MRS, in which the ratios of macromolecule peak intensities are used…
View article: Quantitative MR Image Reconstruction Using Parameter-Specific Dictionary Learning With Adaptive Dictionary-Size and Sparsity-Level Choice
Quantitative MR Image Reconstruction Using Parameter-Specific Dictionary Learning With Adaptive Dictionary-Size and Sparsity-Level Choice Open
From a clinical perspective, the obtained T1-maps could be utilized to differentiate between healthy subjects and patients with Alzheimer's disease. From a technical perspective, the proposed unsupervised method could be employe…
View article: Preoperative thalamus volume is not associated with preoperative cognitive impairment (preCI) or postoperative cognitive dysfunction (POCD)
Preoperative thalamus volume is not associated with preoperative cognitive impairment (preCI) or postoperative cognitive dysfunction (POCD) Open
View article: 7T amygdala and hippocampus subfields in volumetry-based associations with memory: A 3-year follow-up study of early Alzheimer’s disease
7T amygdala and hippocampus subfields in volumetry-based associations with memory: A 3-year follow-up study of early Alzheimer’s disease Open
Volumes of amygdala ROIs, as determined by 7T MRI, might contribute to objectively and non-invasively identify patients with SCD, and thus aid early diagnosis and treatment of individuals at risk to develop dementia due to AD, however asso…
View article: 7T Amygdala and Hippocampus Subfields in Volumetry-Based Associations with Memory: A 3-Year Follow-Up Study of Early Alzheimer's Disease
7T Amygdala and Hippocampus Subfields in Volumetry-Based Associations with Memory: A 3-Year Follow-Up Study of Early Alzheimer's Disease Open
View article: Postoperative delirium is associated with grey matter brain volume loss
Postoperative delirium is associated with grey matter brain volume loss Open
Delirium is associated with long-term cognitive dysfunction and with increased brain atrophy. However, it is unclear whether these problems result from or predisposes to delirium. We aimed to investigate preoperative to postoperative brain…
View article: Fourier‐based decomposition for simultaneous 2‐voxel <scp>MRS</scp> acquisition with <scp>2SPECIAL</scp>
Fourier‐based decomposition for simultaneous 2‐voxel <span>MRS</span> acquisition with <span>2SPECIAL</span> Open
Purpose To simultaneously acquire spectroscopic signals from two MRS voxels using a multi‐banded 2 spin‐echo, full‐intensity acquired localized (2SPECIAL) sequence, and to decompose the signal to their respective regions by a novel voxel‐G…
View article: Assessment of measurement precision in single‐voxel spectroscopy at 7 T: Toward minimal detectable changes of metabolite concentrations in the human brain in vivo
Assessment of measurement precision in single‐voxel spectroscopy at 7 T: Toward minimal detectable changes of metabolite concentrations in the human brain in vivo Open
Purpose To introduce a study design and statistical analysis framework to assess the repeatability, reproducibility, and minimal detectable changes (MDCs) of metabolite concentrations determined by in vivo MRS. Methods An unbalanced nested…
View article: Pentafluorosulfanyl (SF<sub>5</sub>) as a Superior<sup>19</sup>F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives
Pentafluorosulfanyl (SF<sub>5</sub>) as a Superior<sup>19</sup>F Magnetic Resonance Reporter Group: Signal Detection and Biological Activity of Teriflunomide Derivatives Open
Fluorine (19F) magnetic resonance imaging (MRI) is severely limited by a low signal-to noise ratio (SNR), and tapping it for 19F drug detection in vivo still poses a significant challenge. However, it bears the potent…
View article: Metrological references for person ability in memory tests
Metrological references for person ability in memory tests Open
View article: NeuroMET - SPECIAL MRS Reproducibility
NeuroMET - SPECIAL MRS Reproducibility Open
Magnetic Resonance Spectroscopy Data acquired in 9 healthy volunteers using a SPECIAL Localization with three different adiabatic inversion pulses (hyperbolic secant, WURST, GOIA) at a 7T Magnetom whole-body system (Siemens Healthineers, E…
View article: NeuroMET - SPECIAL MRS Reproducibility
NeuroMET - SPECIAL MRS Reproducibility Open
Magnetic Resonance Spectroscopy Data acquired in 9 healthy volunteers using a SPECIAL Localization with three different adiabatic inversion pulses (hyperbolic secant, WURST, GOIA) at a 7T Magnetom whole-body system (Siemens Healthineers, E…
View article: Frequency drift in MR spectroscopy at 3T
Frequency drift in MR spectroscopy at 3T Open
View article: <i>In vivo</i> detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy
<i>In vivo</i> detection of teriflunomide-derived fluorine signal during neuroinflammation using fluorine MR spectroscopy Open
Background: Magnetic resonance imaging (MRI) is indispensable for diagnosing neurological conditions such as multiple sclerosis (MS). MRI also supports decisions regarding the choice of disease-modifying drugs (DMDs). Determining
View article: Reward Versus Nonreward Sensitivity of the Medial Versus Lateral Orbitofrontal Cortex Relates to the Severity of Depressive Symptoms
Reward Versus Nonreward Sensitivity of the Medial Versus Lateral Orbitofrontal Cortex Relates to the Severity of Depressive Symptoms Open
View article: Metabolite cycled liver <sup>1</sup>H MRS on a 7 T parallel transmit system
Metabolite cycled liver <sup>1</sup>H MRS on a 7 T parallel transmit system Open
Introduction Single‐voxel 1 H MRS in body applications often suffers from respiratory and other motion induced phase and frequency shifts, which lead to incoherent averaging and hence to suboptimal results. Methods Here we show the applica…
View article: The association between frailty and MRI features of cerebral small vessel disease
The association between frailty and MRI features of cerebral small vessel disease Open
View article: European Ultrahigh‐Field Imaging Network for Neurodegenerative Diseases (EUFIND)
European Ultrahigh‐Field Imaging Network for Neurodegenerative Diseases (EUFIND) Open
Introduction The goal of European Ultrahigh‐Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND co…
View article: P3‐442: CEREBRAL GABA, RESTING‐STATE FUNCTIONAL CONNECTIVITY AND MEMORY FUNCTION IN ALZHEIMER'S DISEASE
P3‐442: CEREBRAL GABA, RESTING‐STATE FUNCTIONAL CONNECTIVITY AND MEMORY FUNCTION IN ALZHEIMER'S DISEASE Open
Alzheimer's disease (AD) is clinically characterized by memory decline and aberrant functional connectivity (FC) of the default mode network (Wu et al., 2011, HBM). In particular, a precise coupling between the posterior cingulate cortex (…
View article: Non-Water-Suppressed 1H MR Spectroscopy with Orientational Prior Knowledge Shows Potential for Separating Intra- and Extramyocellular Lipid Signals in Human Myocardium
Non-Water-Suppressed 1H MR Spectroscopy with Orientational Prior Knowledge Shows Potential for Separating Intra- and Extramyocellular Lipid Signals in Human Myocardium Open
View article: A comparison of optimization algorithms for localized in vivo <scp>B</scp><sub>0</sub> shimming
A comparison of optimization algorithms for localized in vivo <span>B</span><sub>0</sub> shimming Open
Purpose To compare several different optimization algorithms currently used for localized in vivo B 0 shimming, and to introduce a novel, fast, and robust constrained regularized algorithm ( ConsTru ) for this purpose. Methods Ten differen…
View article: Session 37: Young investigator forum
Session 37: Young investigator forum Open
View article: Conditions for separation and individual quantification of IMCL and EMCL signals in 1H cardiac MRS
Conditions for separation and individual quantification of IMCL and EMCL signals in 1H cardiac MRS Open
Purpose/Introduction: Cardiac 1H MRS (CMRS) is a promising tool for evaluating myocardial lipid metabolism [1]. However, in order to draw meaningful conclusions about lipid concentrations from CMRS spectra, it is necessary to distinguish b…
View article: Mechanisms of <scp>SNR</scp> and line shape improvement by <i>B</i><sub>0</sub> correction in overdiscrete <scp>MRSI</scp> reconstruction
Mechanisms of <span>SNR</span> and line shape improvement by <i>B</i><sub>0</sub> correction in overdiscrete <span>MRSI</span> reconstruction Open
Purpose Inhomogeneities of the main magnetic field cause line broadening and location‐dependent frequency shifts in brain MRSI. These are often visible despite advanced B 0 shimming. The purpose of this work is to propose an advanced B 0 c…
View article: Non-invasive Investigation of Intramyocellular and Extramyocellular Lipids in the Human Heart using Non-water-suppressed MR Spectroscopy
Non-invasive Investigation of Intramyocellular and Extramyocellular Lipids in the Human Heart using Non-water-suppressed MR Spectroscopy Open
Purpose/Introduction: Cardiac 1H MR-spectroscopy (MRS) is a promising tool for investigating human heart disease1. Previous MRS measurements localized in the human skeletal muscle allow a separation of intramyocellular lipids (IMCL)2 and e…
View article: Fast iterative pre‐emphasis calibration method enabling third‐order dynamic shim updated fMRI
Fast iterative pre‐emphasis calibration method enabling third‐order dynamic shim updated fMRI Open
Purpose To calibrate a pre‐emphasis to sufficiently compensate eddy currents for application of dynamic shim updating to fMRI without extension of scan times. Methods Eddy current effects induced into all shim terms up to third‐order were …