Aric Parnes
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View article: The “flipped visit”: an innovative method to improve medical student self-efficacy through a structured approach in clinic
The “flipped visit”: an innovative method to improve medical student self-efficacy through a structured approach in clinic Open
View article: Real-world impact of emicizumab and immunosuppression on acquired hemophilia A: a multicenter US cohort
Real-world impact of emicizumab and immunosuppression on acquired hemophilia A: a multicenter US cohort Open
Acquired hemophilia A (AHA) is an autoimmune bleeding disorder that is caused by factor VIII (FVIII) autoantibodies with high morbidity and mortality due to bleeding and complications from immunosuppression (IST). To address the real-world…
View article: Origins and diversity of pan-isotype human bone marrow plasma cells
Origins and diversity of pan-isotype human bone marrow plasma cells Open
Bone marrow plasma cells (BMPCs) produce durable, protective IgM, IgG, and IgA antibodies, and in some cases, pro-allergic IgE antibodies, but their properties and sources are unclear. We charted single BMPC transcriptional and clonal hete…
View article: Posttraumatic stress disorder and posttraumatic stress symptoms among adults with hemophilia A and B
Posttraumatic stress disorder and posttraumatic stress symptoms among adults with hemophilia A and B Open
View article: S305: PHASE 2 RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, MULTICENTER STUDY OF RECOMBINANT ADAMTS13 IN PATIENTS WITH IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA
S305: PHASE 2 RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, MULTICENTER STUDY OF RECOMBINANT ADAMTS13 IN PATIENTS WITH IMMUNE-MEDIATED THROMBOTIC THROMBOCYTOPENIC PURPURA Open
Topic: 32. Platelet disorders Background: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare disorder caused by a severe ADAMTS13 deficiency, due to anti-ADAMTS13 autoantibodies. iTTP treatment includes plasma exchange (P…
View article: Patient preference for emicizumab versus prior factor therapy in people with haemophilia A: Results from the HAVEN 3 and HAVEN 4 studies
Patient preference for emicizumab versus prior factor therapy in people with haemophilia A: Results from the HAVEN 3 and HAVEN 4 studies Open
Peer Reviewed
View article: In hemophilia, it just keeps getting better
In hemophilia, it just keeps getting better Open
View article: Polycyclic rash with persistent eosinophilia
Polycyclic rash with persistent eosinophilia Open
A 56-year-old man with no past medical history presented with dry cough and dyspnea. He was given antibiotics and bronchodilators which did not improve his symptoms. Three years after the initial symptoms began, he developed persistent hyp…
View article: Role of gene therapy in Fanconi anemia
Role of gene therapy in Fanconi anemia Open
Gene therapy (GT) has been reported to improve bone marrow function in individuals with Fanconi anemia (FA); however, its clinical application is still in the initial stages. We conducted this systematic review, following the Preferred Rep…
View article: Dana-Farber Cancer Institute/Mass General Brigham Fellowship Response to the COVID-19 Pandemic
Dana-Farber Cancer Institute/Mass General Brigham Fellowship Response to the COVID-19 Pandemic Open
The coronavirus disease (COVID)-19 pandemic has affected graduate medical education training programs, including hematology-oncology fellowship programs, both across the United States and abroad. Within the Dana-Farber Cancer Institute/Mas…
View article: Development and testing of the Satisfaction Questionnaire with Intravenous or Subcutaneous Hemophilia Injection and results from the Phase 3 HAVEN 3 study of emicizumab prophylaxis in persons with haemophilia A without FVIII inhibitors
Development and testing of the Satisfaction Questionnaire with Intravenous or Subcutaneous Hemophilia Injection and results from the Phase 3 HAVEN 3 study of emicizumab prophylaxis in persons with haemophilia A without FVIII inhibitors Open
Introduction Emicizumab is a subcutaneously (SC) administered prophylactic agent for persons with haemophilia A (PwHA). As part of its clinical development, a new instrument was required to measure treatment satisfaction. Aim Describe deve…
View article: A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies
A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies Open
Chemotherapy-induced thrombocytopenia (CIT) frequently complicates cancer treatment causing chemotherapy delays, dose reductions, and discontinuation. There is no FDA-approved agent available to manage CIT. This study retrospectively evalu…
View article: Clinical utility of targeted next-generation sequencing–based screening of peripheral blood in the evaluation of cytopenias
Clinical utility of targeted next-generation sequencing–based screening of peripheral blood in the evaluation of cytopenias Open
View article: A single center experience with romiplostim for the management of chemotherapy‐induced thrombocytopenia
A single center experience with romiplostim for the management of chemotherapy‐induced thrombocytopenia Open
Thrombocytopenia is a frequent complication among cancer patients receiving chemotherapy for which there are limited treatment options. Management is typically limited to platelet transfusions or chemotherapy dose reductions and delays. Ro…
View article: Pregnancy outcomes in inherited bone marrow failure syndromes
Pregnancy outcomes in inherited bone marrow failure syndromes Open
To the editor:
Inherited bone marrow failure syndromes include entities such as Fanconi anemia, Diamond-Blackfan anemia, Shwachman-Diamond syndrome, severe congenital neutropenia, and telomere biology disorders/dyskeratosis congenita (TBD…
View article: A systematic review of religious beliefs about major end-of-life issues in the five major world religions
A systematic review of religious beliefs about major end-of-life issues in the five major world religions Open
Objective: The objective of this study was to examine the religious/spiritual beliefs of followers of the five major world religions about frequently encountered medical situations at the end of life (EoL). Method: This was a systematic re…
View article: Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation
Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation Open
View article: Therapy-related myeloid neoplasms - what have we learned so far?
Therapy-related myeloid neoplasms - what have we learned so far? Open
Therapy-related myeloid neoplasms are neoplastic processes arising as a result of chemotherapy, radiation therapy, or a combination of these modalities given for a primary condition. The disease biology varies based on the etiology and tre…