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View article: Exploring the Therapeutic Potential of Oxo berberine Compound in Arcangelisia flava Root Extract for Breast Cancer Treatment: Metabolite Profiling, Pharmacological Network Analysis, and In Silico and In Vitro Evaluation
Exploring the Therapeutic Potential of Oxo berberine Compound in Arcangelisia flava Root Extract for Breast Cancer Treatment: Metabolite Profiling, Pharmacological Network Analysis, and In Silico and In Vitro Evaluation Open
In summary, this evidence highlights the potent anti-cancer effects of oxo berberine in AFRE against breast cancer.
View article: The effectiveness test of film forming hydrogel (FFH) of Yellow Root Extract (Arcangelisia flava (L.) Merr) on healing burns of male white mice (Mus Musculus)
The effectiveness test of film forming hydrogel (FFH) of Yellow Root Extract (Arcangelisia flava (L.) Merr) on healing burns of male white mice (Mus Musculus) Open
The Burns are conditions where skin tissue is lost due to direct contact with heat energy. Therefore, a preparation was developed as film forming hydrogel (FFH) from yellow root extract. Yellow roots contain alkaloids, flavonoids, and sapo…
View article: Network Pharmacology and Component Analysis Integrated Study to Uncovers the Molecular Mechanisms of Lansium parasiticum Bark Extract in Colon Cancer Treatment
Network Pharmacology and Component Analysis Integrated Study to Uncovers the Molecular Mechanisms of Lansium parasiticum Bark Extract in Colon Cancer Treatment Open
Side effects and risk of resistance are common consequences of colon cancer treatment based on chemotherapy. The medicinal plant originating in Indonesia, Lansium parasiticum bark extract (LPBE), has not been studied much. The purpose of t…
View article: Effect of polar fractions of Marsilea crenata C. Presl. leaves in zebrafish locomotor activity
Effect of polar fractions of Marsilea crenata C. Presl. leaves in zebrafish locomotor activity Open
Neurodegenerative diseases (NDs) are pathological conditions initiated by the loss of neuronal cell structure and the progressive decline in function caused by prolonged neuroinflammation. Postmenopausal women are at a high risk of experie…
View article: Efek Antiinflamasi Ekstrak dan Tablet Daun Kenitu (Chrysophyllum cainito L. ) pada Tikus Wistar (Rattus norvegicus)
Efek Antiinflamasi Ekstrak dan Tablet Daun Kenitu (Chrysophyllum cainito L. ) pada Tikus Wistar (Rattus norvegicus) Open
Pendahuluan : Inflamasi pada persendian akibat kerusakan tulang rawan merupakan ciri dari osteoarthritis (OA). Osteoarthtritis adalah suatu penyakit degeneratif terkait dengan rendahnya kadar estrogen dalam tubuh. Senyawa fitoestrogen memi…
View article: THE DEVELOPMENT AND VALIDATION OF HPLC AND HPTLC-DENSITOMETRY METHODS FOR THE DETERMINATION OF 1, 4-NAPHTHOQUINONE CONTENT IN ELEUTHERINE BULBOSA EXTRACT
THE DEVELOPMENT AND VALIDATION OF HPLC AND HPTLC-DENSITOMETRY METHODS FOR THE DETERMINATION OF 1, 4-NAPHTHOQUINONE CONTENT IN ELEUTHERINE BULBOSA EXTRACT Open
Objective: The aim of this research was to develop and validate identification and Quantitation methods for 1,4-naphthoquinone in the extract of Eleutherine bulbosa. Methods: High-performance liquid chromatography (HPLC) and high-performan…
View article: Qualitative Evaluation on the Use of Pneumonia Antibiotics for Covid-19 Patients at X Hospital Bali in 2020
Qualitative Evaluation on the Use of Pneumonia Antibiotics for Covid-19 Patients at X Hospital Bali in 2020 Open
Coronavirus disease-19 (Covid-19) is a pandemic that has caused various complications, including pneumonia. One of the therapies used in Covid-19 with pneumonia complications is antibiotics. Antibiotics must be used appropriately to preven…
View article: Standardization of Semanggi (Marsilea crenata C. Presl.) Leaves from Benowo District, Surabaya for Standardized Herbal Raw Material
Standardization of Semanggi (Marsilea crenata C. Presl.) Leaves from Benowo District, Surabaya for Standardized Herbal Raw Material Open
Semanggi (Marsilea crenata C. Presl.) is a unique plant that grows in East Java, Indonesia. Its leaves are widely used as ingredients for traditional food. Semanggi leaves contain phytoestrogen compounds that can be used for their antineur…
View article: FORMULASI DAN KARAKTERISASI NANOEMULSI EKSTRAK ETANOL 70% DAUN SEMANGGI (Marsilea crenata C. Presl.)
FORMULASI DAN KARAKTERISASI NANOEMULSI EKSTRAK ETANOL 70% DAUN SEMANGGI (Marsilea crenata C. Presl.) Open
Marsilea crenata C. Presl. mengandung fitoestrogen yang memiliki struktur atau fungsi seperti estrogen, sehingga berpotensi untuk digunakan sebagai neuroprotektor pada kondisi defisiensi estrogen. Namun, ada masalah yang mungkin timbul dar…
View article: Analisis Efektivitas Biaya Terapi Kombinasi Insulin dengan Obat Antidiabetes Oral pada Pasien Rawat Jalan Penderita Diabetes Melitus Tipe 2 di RSUD dr. Soehadi Prijonegoro Sragen
Analisis Efektivitas Biaya Terapi Kombinasi Insulin dengan Obat Antidiabetes Oral pada Pasien Rawat Jalan Penderita Diabetes Melitus Tipe 2 di RSUD dr. Soehadi Prijonegoro Sragen Open
Diabetes melitus tipe 2 (DM 2) adalah penyakit kronis menahun karena resistensi insulin atau akibat dari berkurangnya sekresi insulin oleh sel beta pankreas. Pengobatan DM 2 berupa terapi oral dan insulin . Cost-Effectiveness Analysis adal…
View article: Influence of Chitosan Concentration on Characteristic of Microspheres Delivery System Prepared from Eleutherine palmifolia (L.) Merr. Extract
Influence of Chitosan Concentration on Characteristic of Microspheres Delivery System Prepared from Eleutherine palmifolia (L.) Merr. Extract Open
Background: Eleutherine palmifolia (L.) Merr. (E.palmifolia) is a medicinal plant containing naphthoquinone, isoliquiritigenin, and oxyresveratrol compound. This study aims to formulate and characterize the E. palmifolia microspheres deliv…
View article: Perbedaan Tingkat Pengetahuan Siswa SMA Darul Kholil Burneh Bangkalan tentang Obat Generik Antara Sebelum dan Setelah Edukasi
Perbedaan Tingkat Pengetahuan Siswa SMA Darul Kholil Burneh Bangkalan tentang Obat Generik Antara Sebelum dan Setelah Edukasi Open
Obat generik merupakan program Pemerintah Indonesia untuk meningkatkan kualitas kesehatan di Indonesia. Namun, masih banyak yang belum mengetahui tentang obat generik, sehingga perlu adanya pemberian edukasi untuk meningkatkan pengetahuan …
View article: Inflammatory cytokines affecting cardiovascular function: a scoping review
Inflammatory cytokines affecting cardiovascular function: a scoping review Open
Background: A chronic inflammatory process can cause disorders on the cardiovascular system. It is caused by an enhancement of inflammatory cytokines that can decrease the heart working-function. This article aims to review inflammatory cy…
View article: Induction of Helianthus annuus Leaves Extract to HeLa cell Apoptosis and Cell Cycle Arrest in S, G2-M and M5 Phase
Induction of Helianthus annuus Leaves Extract to HeLa cell Apoptosis and Cell Cycle Arrest in S, G2-M and M5 Phase Open
Helianthus annuus L. (H. annuus) is a potential medicinal plant for cancer therapy. The aims of this study is to identify profile the anticancer activity of H. annuus L. from its leaves, root, stem, and seed as well as to elucidate the apo…
View article: Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N)
Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N) Open
Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV. These considera…
View article: Potensi Senyawa Nitazoxanide dan Arbidol sebagai Antivirus SARS-CoV-2 terhadap Reseptor NSP5 (7BQY dan 2GZ7) dan ACE2 (3D0G dan 1R4L)
Potensi Senyawa Nitazoxanide dan Arbidol sebagai Antivirus SARS-CoV-2 terhadap Reseptor NSP5 (7BQY dan 2GZ7) dan ACE2 (3D0G dan 1R4L) Open
Nitazoxanide merupakan obat pro-drug untuk tizoxanide. Obat tersebut diketahui memiliki aktivitas antivirus pada MERS-CoV. Arbidol memiliki aktivitas antivirus pada H3N2 HA yang memiliki kesamaan struktur dengan SARS-CoV-2. Reseptor target…
View article: Metabolite profiling and activity studyof ethanol extract of Chrysophyllum cainito L. leaves in increasing bone density in male mice
Metabolite profiling and activity studyof ethanol extract of Chrysophyllum cainito L. leaves in increasing bone density in male mice Open
Phytoestrogen is a group compound which has an estrogen-like structure or function. One of its roles was in the bone formation. Chrysophyllum cainito L. is a plant that contains phytoestrogen. The purpose of this research is to determine t…
View article: Inhibition of Human Epidermal Growth Factor Receptor-2 (HER-2) from Pomelo (Citrus maxima) Flavonoid Compounds: an In Silico Approach
Inhibition of Human Epidermal Growth Factor Receptor-2 (HER-2) from Pomelo (Citrus maxima) Flavonoid Compounds: an In Silico Approach Open
Citrus maxima or pomelo is a plant that has potential as an anticancer because it contains flavonoids. One of the targets of breast anticancer receptors is the HER-2 protein. This research aims to determine the anticancer activity, the tox…
View article: Analisis Kandungan Logam Berat Cd, Hg, dan Pb Daun Semanggi (Marsilea crenata Presl.) di Desa Semen, Kecamatan Pagu, Kabupaten Kediri
Analisis Kandungan Logam Berat Cd, Hg, dan Pb Daun Semanggi (Marsilea crenata Presl.) di Desa Semen, Kecamatan Pagu, Kabupaten Kediri Open
Semanggi (Marsilea crenata Presl.) berpotensi untuk diolah menjadi produk obat herbal karena khasiat yang dimilikinya. Namun, tanaman semanggi (Marsilea crenata Presl.) memiliki kemampuan fitoremediasi sehingga berdampak pada penimbunan lo…
View article: Kajian Efek Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr) sebagai Antikanker
Kajian Efek Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr) sebagai Antikanker Open
Dayak onion ( Eleutherine palmifolia (L.) Merr) is a typical plant in Central Kalimantan. This plant has been passed down for generations by Indonesian people for various treatments. The potential of dayak onions that have various pharmaco…
View article: Activity and Toxicity of Eleutherine palmifolia (L.) Merr. Extract on BALB/c Mice Colitis-Associated Colon Cancer Model
Activity and Toxicity of Eleutherine palmifolia (L.) Merr. Extract on BALB/c Mice Colitis-Associated Colon Cancer Model Open
This study indicate that EPE could be recommended as a colon anticancer through increase the goblet cells, induce apoptosis through increase TNF-α, and decrease TGF-β.
View article: The Profile of Anticancer Activities of Sambiloto Extract (Andrographis paniculata Nees) from Several Locations in East Java
The Profile of Anticancer Activities of Sambiloto Extract (Andrographis paniculata Nees) from Several Locations in East Java Open
Sambiloto (Andrographis paniculata Nees) contains andrographolid compound which has potentialas an anticancer. The difference of growth location has affected the distinction of metabolite content. Thisstudy aims to determine the profile of…
View article: METABOLOMIC COMPOUND OF Calostropis gigantea ROOT EXTRACT AND THE INHIBITION EFFECT ON FIBROSARCOMA GROWTH AND CASPASE 3 EXPRESSION ON BALB/C Mus musculus
METABOLOMIC COMPOUND OF Calostropis gigantea ROOT EXTRACT AND THE INHIBITION EFFECT ON FIBROSARCOMA GROWTH AND CASPASE 3 EXPRESSION ON BALB/C Mus musculus Open
The root of Calotropis gigantea (thistle) is an Indonesian herb to treat cancer based on empirical and scientific evidences. The study aims to find out the infuence of ethanol extract of Calotropis gigantea root …
View article: Metabolite Profiling of 96% Ethanol Extract from Marsilea crenata Presl. Leaves Using UPLC-QToF-MS/MS and Anti-Neuroinflammatory Predicition Activity with Molecular Docking
Metabolite Profiling of 96% Ethanol Extract from Marsilea crenata Presl. Leaves Using UPLC-QToF-MS/MS and Anti-Neuroinflammatory Predicition Activity with Molecular Docking Open
Phytoestrogen is a group of compounds that can replace the estrogen function in the body. One of its roles was as anti-neuroinflammatory by inhibiting the microglia M1 polarity activation. Marsilea crenata Presl. is a plant that suspected …
View article: Development of an antimicrobial gel formulation for topical delivery using silver nanoparticle
Development of an antimicrobial gel formulation for topical delivery using silver nanoparticle Open
Nanosilver is an antibacterial agent that can inhibit the growth of gram-positive bacteria such as Staphylococcus aureus. The small size makes nanosilver enhance its antibacterial properties. Nanosilver can be used as an active ingredient …
View article: Metabolite Profiling Bagian Akar, Batang, Daun, dan Biji Helianthus annuus L. Menggunakan Instrumen UPLC-MS
Metabolite Profiling Bagian Akar, Batang, Daun, dan Biji Helianthus annuus L. Menggunakan Instrumen UPLC-MS Open
Sunflower (Helianthus annuus L.) is one of the plants that can be used for herbal medicine as antimalaria and antioxidant. To control the quality of plant as raw material of herbal medicine, we need to analyze the metabolites or chemical c…
View article: Activity of inhibit the cell cycle and induct apoptosis in HeLa cancer cell with combination of Sabrang onion (Eleutherine palmifolia (L.) Merr) and Starfruit Mistletoe (Macrosolen cochinchinensis (Lour.) Tiegh)
Activity of inhibit the cell cycle and induct apoptosis in HeLa cancer cell with combination of Sabrang onion (Eleutherine palmifolia (L.) Merr) and Starfruit Mistletoe (Macrosolen cochinchinensis (Lour.) Tiegh) Open
The combination of Eleutherine palmifolia (L.) Merr (EP) and Macrosolen cochinchinensis (Lour.) Tiegh (MC) extracts has been proven an empirically potential cure for cancer. The aims of this research were to prove scientifically the antica…
View article: UJI SITOTOKSIK KOMBINASI CISPLATIN DENGAN EKSTRAK ETANOL BENALU ALPUKAT (Dendrophthoe pentandra (L) Miq.) PADA SEL HELA
UJI SITOTOKSIK KOMBINASI CISPLATIN DENGAN EKSTRAK ETANOL BENALU ALPUKAT (Dendrophthoe pentandra (L) Miq.) PADA SEL HELA Open
Benalu alpukat (Dendrophthoe pentandra (L) Miq.) secara empiris telah digunakan sebagai obat antikanker oleh masyarakat Indonesia. Pada penelitian sebelumnya dilaporkan bahwa tanaman tersebut mengandung senyawa kuersetin. Penelitian ini be…
View article: ACTIVITY OF ETHYL ACETATE EXTRACT FROM Chrysophyllum cainito L. LEAVES IN DECREASING BLOOD SUGAR LEVEL IN MALE WISTAR RATS
ACTIVITY OF ETHYL ACETATE EXTRACT FROM Chrysophyllum cainito L. LEAVES IN DECREASING BLOOD SUGAR LEVEL IN MALE WISTAR RATS Open
The high morbidity or mortality due to diabetes mellitus becomes the world health problem. That fact encourages the study about antidiabetes drugs from natural material especially plants. This study aims to analyze the effect of <…