Ariel Buchler
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View article: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway
PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway Open
While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging body of literature suggests that PD-L1 has cell-intrinsic functions in immune and cancer cells. In line with these studies, here we …
View article: Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in Atherosclerosis
Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in Atherosclerosis Open
Matrix metalloproteinase-13 (MMP-13) plays a critical role in the progression of unstable atherosclerosis. A series of highly potent and selective MMP-13 inhibitors were synthesized around a quinazoline-2-carboxamide scaffold to facilitate…
View article: Synthesis and Evaluation of [<sup>11</sup>C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis
Synthesis and Evaluation of [<sup>11</sup>C]MCC950 for Imaging NLRP3-Mediated Inflammation in Atherosclerosis Open
Overexpression of the NLRP3 inflammasome has been attributed to the progressive worsening of a multitude of cardiovascular inflammatory diseases such as myocardial infarction, pulmonary arterial hypertension, and atherosclerosis. The recen…
View article: More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway
More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway Open
Targeting the PD-1/PD-L1 axis has transformed the field of immune-oncology. While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging body of literature suggests that PD-L1 has cell-intrinsi…
View article: Cardiac Sympathetic Positron Emission Tomography Imaging with <i>Meta</i>-[<sup>18</sup>F]Fluorobenzylguanidine is Sensitive to Uptake-1 in Rats
Cardiac Sympathetic Positron Emission Tomography Imaging with <i>Meta</i>-[<sup>18</sup>F]Fluorobenzylguanidine is Sensitive to Uptake-1 in Rats Open
Dysfunction of the cardiac sympathetic nervous system contributes to the development of cardiovascular diseases including ischemia, heart failure, and arrhythmias. Molecular imaging probes such as meta-[123I]iodobenzylgua…