Explanipedia

Divergent trajectories and risk profiles of multimorbidity among people living with HIV in China Open

Chao Liu, Liqin Sun, Xi Xiao, Yun He, Fang Zhao , et al. · 2025

Background: With increased longevity among people living with HIV (PLWH), multimorbidity has emerged as a critical challenge, occurring at younger ages and involving both non-communicable diseases and persistent infections. Yet its long-te…

MON-386 Subacute Thyroiditis Simulating Thyroid Malignancy: A Case Report Open

Melissa Claire Uy, Chao Liu · 2025

Disclosure: M.K. Uy: None. C.C. Liu: None. Subacute thyroiditis occurs most often in middle-aged women and has been associated with viral infection. A 37-year-old female presented with anterior neck pain resolving after a course of cortico…

RNF168 dephosphorylation ameliorates cognitive decline in Aβ-based mouse models of Alzheimer’s disease Open

Miao‐Jin Ji, Yun Li, Yang Jiao, Kangjunjie Wang, Shuxun Sang , et al. · 2025

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder among the elderly, with limited effective treatments available in clinical practice. Impaired glucose metabolism has long been observed in the brains of AD patients,…

153 Intestinal Cooling Prevents Sepsis Without Coagulopathy During REBOA Management of Hemorrhage Open

Baer Hu, A. Chen, Young Nyun Park, Yamileck Olivas-Garcia, Chao Liu , et al. · 2025

Two-threshold defined immune non-responders are associated with long-term morbidity in people with HIV: a prospective cohort study Open

Xiaorui Li, Liqin Sun, Yun He, Fang Zhao, Yinsong Luo , et al. · 2025

A substantial proportion of people with HIV (PWH) fail to achieve full immune recovery despite long-term antiretroviral therapy (ART), potentially increasing their risk of serious comorbidities. This study investigated the association betw…

Regulation of partial endothelial-to-mesenchymal transition by circATXN1 in ischemic diseases Open

Yue Li, Zhe Zheng, Yanze Li, Siyuan Fan, Lingyao Kong , et al. · 2025

Electroacupuncture reshapes the microbial co‐occurrence networks related to the behavioral and psychological symptoms of dementia in Alzheimer's disease Open

F. C. Su, Chun-Yen Lin, Chao Liu, Yiqin Yao, Hui Wang , et al. · 2025

Piezoelectric-IL-4 programmed regulation of immuno-microenvironment-induced mesenchymal stem cell recruitment and differentiation for bone regeneration Open

Jiahao Zhang, Wenhan Wang, Mengjia Wang, Han Hai, Keyi Li , et al. · 2025

HDL-C as a novel predictor of immune reconstitution in people living with HIV: insights from a baseline-to-dynamic change cohort study in China, 2005–2022 Open

Xiaorui Li, Liqin Sun, Yun He, Fang Zhao, Yinsong Luo , et al. · 2025

Background High-density lipoprotein cholesterol (HDL-C) is a well-established marker of lipid metabolism and increasingly recognized as an indicator of inflammatory status. This study investigates HDL-C’s role as a predictor of immune reco…

Preparation, Characterization, and Pharmacokinetic Study of Ternary Solid Dispersions Using a Mixed Matrix with Soluplus: A Case Study of Diosgenin Open

Mengyu Zhao, Yiyang Zhang, Jing Li, Chao Liu, Jinhua Chang , et al. · 2025

Trends and Cross-Regional Inequalities in the Global Burden of Four Vertical Transmission Infectious Diseases Among Women of Childbearing Age: A Systematic Analysis and Predictions to 2050 Based on the Global Burden of Disease Study 2021 Open

Jinhui Zhao, Yinsong Luo, Xi Xiao, Yuxin Jiang, Xiaorui Li , et al. · 2025

Serum Medium-Chain Fatty Acids and the Risk of Incident Diabetes: Findings From the 4C Study Open

Xiaojing Jia, Hong Lin, Yilan Ding, Xuejiang Gu, Shuangyuan Wang , et al. · 2024

Context Emerging studies have revealed associations between dietary medium-chain fatty acids (MCFAs) and glucose homeostasis. However, the relationship between serum MCFAs and the incidence of diabetes, and potential interactions with gene…

Correction: E4bp4-Cyp3a11 axis in high-fat diet-induced obese mice with weight fluctuation Open

Shuoshuo Sun, Ruixiang Zhang, Yu Chen, Yijiao Xu, Xingjia Li , et al. · 2024

MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis Open

Hongbo Zhang, Chaoyue Li, Lin Han, Yao Xiao, Ji Bian , et al. · 2024

Alcohol-related liver disease (ALD) is recognized as a global health crisis, contributing to approximately 20% of liver cancer-associated fatalities. Dysbiosis of the gut microbiome is associated with the development of ALD, with the gut m…

E4bp4-Cyp3a11 axis in high-fat diet-induced obese mice with weight fluctuation Open

Shuoshuo Sun, Ruixiang Zhang, Yu Chen, Yijiao Xu, Xingjia Li , et al. · 2024

Objective Weight regain after weight loss is a challenge in obesity management. The metabolic changes and underlying mechanisms in obese people with weight fluctuation remain to be elucidated. In the present study, we aimed to profile the …

Elevated left ventricular end diastolic pressure is associated with increased risk of contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention Open

Chao Liu, Melissa C. Caughey, Jr. Smith, Xiaotong Dai · 2024

Aims: To study the correlation between intra-procedural left ventricular end-diastolic pressure (LVEDP) and the development of contrast-induced acute kidney injury (CI-AKI) in patients undergoing percutaneous coronary intervention (PCI). M…

The HSP90AB1-mediated upregulation of IDO1 can promote the progression of colorectal cancer Open

Chenchen Jin, Xuejiao Xu, Tao Li, Chunxue Zhang, Jianqing Peng , et al. · 2024

Objectives Colorectal cancer (CRC) is a global challenge, and heat shock protein 90 (HSP90) is identified as a key driver in cancer progression. However, the tumor-promoting mechanism of HSP90 in CRC, particularly HSP90AB1, remains unclear…

UBI29-41-targeted, NIR-triggered nanoparticles for enhanced PDT against periodontal plaque biofilm formation and immunomodulation Open

Wen Li, Fengqun You, Han Bao, Jie Yang, Deao Gu , et al. · 2024

Periodontitis, a prevalent inflammatory disease affecting the oro-maxillofacial region, is induced by dental plaque biofilms. Periodontitis not only causes the degradation of supporting periodontal tissues but also poses a significant thre…

lncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke Open

Yin-Hua Weng, Jie Chen, Wentao Yu, Yanping Luo, Chao Liu , et al. · 2024

Background Ischemic stroke (IS) is a common and serious neurological condition that is highly fatal but so far no early diagnostic markers are available. Myocardial infarction-associated transcript (MIAT) is a long non-coding RNA (lncRNA) …

Global, Regional, and National Burden of Pertussis In Children Aged 0–14 Years from 1990–2021: A Systematic Analysis for the Global Burden of Disease Study 2021 Open

Yinsong Luo, Xi Xiao, Yuxin Jiang, Xiaorui Li, Lingyun Ge , et al. · 2024

Global, Regional, and National Burdens of Vaccine-Preventable Infectious Diseases with High Incidence Among Middle-Aged and Older Adults Aged 55--89 Years from 1990--2021: Results from the Global Burden of Disease Study 2021 Open

Yuxin Jiang, Yinsong Luo, Xi Xiao, Xiaorui Li, Yiyao Hu , et al. · 2024

Landscape of cancer clinical trials in India – a comprehensive analysis of the Clinical Trial Registry-India Open

Peng Gao, Justin Chen, Zhongyu Hong, M. Choi, Allison M. Morgan , et al. · 2023

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice Open

Chao Liu, Srilakshmi Yalavarthi, Ajay Tambralli, Lixia Zeng, Christine E. Rysenga , et al. · 2023

While neutrophil extracellular traps (NETs) have previously been linked to some diabetes-associated complications, such as dysfunctional wound healing, their potential role in diabetic vascular dysfunction has not been studied. Diabetic Ak…

Trelagliptin relieved cognitive impairment of diabetes mellitus rats: Involvement of PI3K/Akt/GSK-3β and inflammation pathway Open

Min Lei, Xiying Guo, Yue Yao, Ting Shu, Zhanhong Ren , et al. · 2023

Cognitive impairment frequently coexists with diabetes. Trelagliptin is a once-weekly taking selective dipeptidyl peptidase-4 (DPP-4) inhibitor and a long-term effective hypoglycemic medicine; nonetheless, its effects for the treatment of …

Association between miR-365 polymorphism and ischemic stroke in a Chinese population Open

Yin-Hua Weng, Wentao Yu, Yanping Luo, Chao Liu, Xixi Gu , et al. · 2023

Background Ischemic stroke (IS) represents a major cause of morbidity and mortality across the globe. The aberrant expression of miR-365 has been found to be implicated in a wide array of human diseases, including atherosclerosis and cance…

Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats Open

Xiying Guo, Min Lei, Jiangyan Zhao, Min Wu, Zhanhong Ren , et al. · 2023

Background: One of the typical symptoms of diabetes mellitus patients was memory impairment, which was followed by gradual cognitive deterioration and for which there is no efficient treatment. The anti-diabetic incretin hormones glucose-d…

Functional polymorphism in miR-208 is associated with increased risk for ischemic stroke Open

Chao Liu, Yanping Luo, Jie Chen, Yin-Hua Weng, Yan Lan , et al. · 2023

Background The miR-208 gene is one of the microRNAs now under active studies, and has been found to play significant roles in an array of cardiovascular diseases. Nevertheless, until now, no studies have examined the relationship between t…

P-650 Follicular extracellular vesicles of older women inhibit oocyte maturation Open

Chao Liu, Haijun Yao, Mengge Cui, Xun Gong, Yiqun Chen · 2023

Study question Whether follicular extracellular vesicles of older women interfere with the quality of oocytes. Summary answer OLD-EVs induced the oxidative stress in the oocytes and inhibited oocyte maturation by increasing the abnormal mi…

P-032 Exploration of the common genetic landscape of COVID-19 and male infertility Open

Yuerong Chen, Ping Yuan, Chao Liu · 2023

Study question What is the cross-talk molecular mechanisms between COVID-19 and male infertility? Summary answer The present study identified and validated hub COVID-19-related differentially expressed genes (CORGs) in COVID-19 and male in…

O-059 ntermetabolites of cholesterol synthesis in granulosa cell and oocyte aging Open

Chao Liu, Dai Li-jun, Haixiang Sun · 2023

With the development of society, there has been a significant delay in female fertility and an increasing desire for childbearing among females of advanced maternal age in recent decades. Nevertheless, women over 35 years old have more ris…

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