Ariel Edward Hight
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View article: Distinct cortical encoding of acoustic and electrical cochlear stimulation
Distinct cortical encoding of acoustic and electrical cochlear stimulation Open
Cochlear implants are neuroprosthetic devices that restore hearing and speech comprehension to profoundly deaf humans, and represent an exemplar application of biomedical engineering and research to clinical conditions. However, the utilit…
View article: Distinct cortical encoding of acoustic and electrical cochlear stimulation
Distinct cortical encoding of acoustic and electrical cochlear stimulation Open
Cochlear implants are neuroprosthetic devices that restore hearing and speech comprehension to profoundly deaf humans, and represent an exemplar application of biomedical engineering and research to clinical conditions. However, the utilit…
View article: Distinct cortical encoding of acoustic and electrical cochlear stimulation
Distinct cortical encoding of acoustic and electrical cochlear stimulation Open
Cochlear implants are neuroprosthetic devices that restore hearing and speech comprehension to profoundly deaf humans, and represent an exemplar application of biomedical engineering and research to clinical conditions. However, the utilit…
View article: Neural signatures of auditory hypersensitivity following acoustic trauma
Neural signatures of auditory hypersensitivity following acoustic trauma Open
Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations in afferent activity levels. However, sudden peripheral deafferentation in adulthood can trigger an excessive, non-homeostat…
View article: Author response: Neural signatures of auditory hypersensitivity following acoustic trauma
Author response: Neural signatures of auditory hypersensitivity following acoustic trauma Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neurons in sensory cor…
View article: Neural signatures of auditory hypersensitivity following acoustic trauma
Neural signatures of auditory hypersensitivity following acoustic trauma Open
Throughout the brain, neurons exhibit a remarkable capacity to maintain stable firing rates despite large perturbations in afferent activity levels. As an exception, homeostatic regulation of neural activity often fails in the adult audito…
View article: Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI)
Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI) Open
View article: Supporting Equity and Inclusion of Deaf and Hard-of-Hearing Individuals in Professional Organizations
Supporting Equity and Inclusion of Deaf and Hard-of-Hearing Individuals in Professional Organizations Open
Disability is an important and often overlooked component of diversity. Individuals with disabilities bring a rare perspective to science, technology, engineering, mathematics, and medicine (STEMM) because of their unique experiences appro…
View article: Supporting Equity and Inclusion of Deaf and Hard-Of-Hearing Individuals in Professional Organizations
Supporting Equity and Inclusion of Deaf and Hard-Of-Hearing Individuals in Professional Organizations Open
Disability is an important and often overlooked component of diversity. Individuals with disabilities bring a rare perspective to science, technology, engineering, mathematics, and medicine (STEMM) because of their unique experiences appro…
View article: Increasing the expression level of ChR2 enhances the optogenetic excitability of cochlear neurons
Increasing the expression level of ChR2 enhances the optogenetic excitability of cochlear neurons Open
Optogenetics comprise a promising alternative to electrical stimulation for characterization of neural circuits and for the next generation of neural prostheses. Optogenetic stimulation relies on expression of photosensitive microbial prot…
View article: Optical Approaches for Neuroprosthetic Stimulation and Chronic Visualization of Sound Processing in the Adult Auditory System
Optical Approaches for Neuroprosthetic Stimulation and Chronic Visualization of Sound Processing in the Adult Auditory System Open
Disabling hearing loss affects approximately 433 million people world-wide, resulting in impaired speech comprehension and associated hearing disorders including tinnitus and hyperacusis. Auditory multi-channel neuroprosthetic devices are …
View article: Cellular and Widefield Imaging of Sound Frequency Organization in Primary and Higher Order Fields of the Mouse Auditory Cortex
Cellular and Widefield Imaging of Sound Frequency Organization in Primary and Higher Order Fields of the Mouse Auditory Cortex Open
The mouse auditory cortex (ACtx) contains two core fields—primary auditory cortex (A1) and anterior auditory field (AAF)—arranged in a mirror reversal tonotopic gradient. The best frequency (BF) organization and naming scheme for additiona…
View article: Increasing the Expression Level of ChR2 Enhances the Optogenetic Excitability of Cochlear Neurons
Increasing the Expression Level of ChR2 Enhances the Optogenetic Excitability of Cochlear Neurons Open
This study reveals a dose-response relationship between channelrhodopsin expression and optogenetic excitation. Both single cell and organismal responses depend on the expression level of the heterologous protein. Expression level of the o…
View article: Increasing the Expression Level of ChR2 Enhances the Optogenetic Excitability of Cochlear Neurons
Increasing the Expression Level of ChR2 Enhances the Optogenetic Excitability of Cochlear Neurons Open
This study reveals a dose-response relationship between channelrhodopsin expression and optogenetic excitation. Both single cell and organismal responses depend on the expression level of the heterologous protein. Expression level of the o…
View article: Cellular and widefield imaging of sound frequency organization in primary and higher-order fields of the mouse auditory cortex
Cellular and widefield imaging of sound frequency organization in primary and higher-order fields of the mouse auditory cortex Open
The mouse auditory cortex (ACtx) contains two core fields – A1 and AAF – arranged in a mirror reversal tonotopic gradient. The best frequency (BF) organization and naming scheme for additional higher-order fields remain a matter of debate,…
View article: Auditory brainstem stimulation with a conformable microfabricated array elicits responses with tonotopically organized components
Auditory brainstem stimulation with a conformable microfabricated array elicits responses with tonotopically organized components Open
View article: Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants
Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants Open
View article: A biophysical model examining the role of low-voltage-activated potassium currents in shaping the responses of vestibular ganglion neurons
A biophysical model examining the role of low-voltage-activated potassium currents in shaping the responses of vestibular ganglion neurons Open
The vestibular nerve is characterized by two broad groups of neurons that differ in the timing of their interspike intervals; some fire at highly regular intervals, whereas others fire at highly irregular intervals. Heterogeneity in ion ch…
View article: Hearing the light: neural and perceptual encoding of optogenetic stimulation in the central auditory pathway
Hearing the light: neural and perceptual encoding of optogenetic stimulation in the central auditory pathway Open
View article: Direct Visualization of the Murine Dorsal Cochlear Nucleus for Optogenetic Stimulation of the Auditory Pathway
Direct Visualization of the Murine Dorsal Cochlear Nucleus for Optogenetic Stimulation of the Auditory Pathway Open
Investigation into the use of virus-mediated gene transfer to arrest or reverse hearing loss has largely been relegated to the peripheral auditory system. Few studies have examined gene transfer to the central auditory system. The dorsal c…
View article: Superior temporal resolution of Chronos versus channelrhodopsin-2 in an optogenetic model of the auditory brainstem implant
Superior temporal resolution of Chronos versus channelrhodopsin-2 in an optogenetic model of the auditory brainstem implant Open
View article: Temporal Resolution of ChR2 and Chronos in an Optogenetic-based Auditory Brainstem Implant Model: Implications for the Development and Application of Auditory Opsins
Temporal Resolution of ChR2 and Chronos in an Optogenetic-based Auditory Brainstem Implant Model: Implications for the Development and Application of Auditory Opsins Open
View article: Conducting polymer electrodes for auditory brainstem implants
Conducting polymer electrodes for auditory brainstem implants Open
PEDOT:PSS films are integrated in a flexible neural implant to safely transduce electrical pulses to stimulate the auditory brainstem.