Ariel Lin
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View article: Suspended Tissue Engineering with Assemblable Microfluidics (STEAM)
Suspended Tissue Engineering with Assemblable Microfluidics (STEAM) Open
Suspended tissue culture systems enable cellular responses to mechanical forces critical for tissue development and function. Tissues develop in a complex environment containing both mechanical and chemical cues that vary spatiotemporally;…
View article: Suspended Tissue Open Microfluidic Patterning (STOMP)
Suspended Tissue Open Microfluidic Patterning (STOMP) Open
Free‐standing tissue structures tethered between pillars are powerful mechanobiology tools for studying cell contraction. To model interfaces ubiquitous in natural tissues and upgrade existing single‐region suspended constructs, we develop…
View article: Suspended Tissue Open Microfluidic Patterning (STOMP)
Suspended Tissue Open Microfluidic Patterning (STOMP) Open
Free-standing tissue structures tethered between pillars are powerful mechanobiology tools for studying cell contraction. To model interfaces ubiquitous in natural tissues and upgrade existing single-region suspended constructs, we develop…
View article: SNARE chaperone Sly1 directly mediates close-range vesicle tethering
SNARE chaperone Sly1 directly mediates close-range vesicle tethering Open
The essential Golgi protein Sly1 is a member of the Sec1/mammalian Unc-18 (SM) family of SNARE chaperones. Sly1 was originally identified through remarkable gain-of-function alleles that bypass requirements for diverse vesicle tethering fa…
View article: SM protein Sly1 and a SNARE Habc domain promote membrane fusion through multiple mechanisms
SM protein Sly1 and a SNARE Habc domain promote membrane fusion through multiple mechanisms Open
SM proteins including Sly1 are essential cofactors of SNARE-mediated membrane fusion. Using SNARE and Sly1 mutants and chemically defined in vitro assays, we separate and assess proposed mechanisms through which Sly1 augments fusion: (i) o…
View article: Gatekeeper helix activates Golgi SM protein Sly1 and directly mediates close-range vesicle tethering
Gatekeeper helix activates Golgi SM protein Sly1 and directly mediates close-range vesicle tethering Open
The essential Golgi protein Sly1 is a member of the SM ( S ec1/ m ammalian Unc-18) family of SNARE chaperones. Sly1 was originally identified through gain-of-function alleles that bypass requirements for diverse vesicle tethering factors. …
View article: Gyp8 is a Membrane-anchored Rab GAP (GTPase Accelerating protein) whose Correct Targeting to Peroxisomes Depends Upon Chaperone Msp1
Gyp8 is a Membrane-anchored Rab GAP (GTPase Accelerating protein) whose Correct Targeting to Peroxisomes Depends Upon Chaperone Msp1 Open
Eukaryotic cells use vesicular transport pathways to build and maintain membrane-bound organelles that house specific biochemical functions. Rab GTPase signaling proteins (Rabs) are key regulators of vesicular transport, controlling where …
View article: Affective Circuitry Alterations in Patients with Trigeminal Neuralgia
Affective Circuitry Alterations in Patients with Trigeminal Neuralgia Open
Trigeminal neuralgia (TN) is a severe chronic neuropathic facial pain disorder. Affect-related behavioral and structural brain changes have been noted across chronic pain disorders, but have not been well-studied in TN. We examined the pot…