Ariel Munitz
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View article: Distinct Roles for Thymic Stromal Lymphopoietin ( <scp>TSLP</scp> ) and <scp>IL</scp> ‐33 in Experimental Eosinophilic Esophagitis
Distinct Roles for Thymic Stromal Lymphopoietin ( <span>TSLP</span> ) and <span>IL</span> ‐33 in Experimental Eosinophilic Esophagitis Open
Rationale Thymic stromal lymphopoietin (TSLP) and IL‐33 are alarmins implicated in eosinophilic esophagitis (EoE) pathogenesis by activating multiple cells, including mast cells (MCs). Whether TSLP or IL‐33 have a role in EoE and whether t…
View article: Engineering mice for female-biased progeny without impacting genetic integrity and litter size
Engineering mice for female-biased progeny without impacting genetic integrity and litter size Open
Generating mammalian gametes with a skewed sex ratio has thus far eluded empirical confirmation. The utilization of such genetically engineered organisms would offer the potential to curtail the necessity for culling animals of undesirable…
View article: Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis
Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitis Open
Rationale Thymic stromal lymphopoietin (TSLP) and IL-33 are alarmins implicated in EoE pathogenesis by activating multiple cells including mast cells (MCs). Whether TSLP or IL-33 have a role in EoE and whether their activities are distinct…
View article: Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy
Crosslinking of Ly6a metabolically reprograms CD8 T cells for cancer immunotherapy Open
View article: Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities
Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities Open
Rare eosinophil-associated disorders (EADs), including hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis, and eosinophilic gastrointestinal disorders, are a heterogeneous group of conditions characterized by blood a…
View article: A Mouse Model for Eosinophilic Esophagitis (EoE)
A Mouse Model for Eosinophilic Esophagitis (EoE) Open
Eosinophilic esophagitis (EoE) is an emerging chronic T helper type 2 (Th2)‐associated, allergic, and immune‐mediated disease, characterized histologically by eosinophil‐predominant mucosal inflammation and clinically by esophageal dysfunc…
View article: Nephron-Specific <i>Lin28A</i> Overexpression Triggers Severe Inflammatory Response and Kidney Damage
Nephron-Specific <i>Lin28A</i> Overexpression Triggers Severe Inflammatory Response and Kidney Damage Open
The RNA-binding proteins LIN28A and LIN28B contribute to a variety of developmental biological processes. Dysregulation of Lin28A and Lin28B expression is associated with numerous types of tumors. This study demonstrates that…
View article: Engineering mice for female-biased progeny without impacting genetic integrity and litter size
Engineering mice for female-biased progeny without impacting genetic integrity and litter size Open
Generating mammalian gametes with a skewed sex ratio has thus far eluded empirical confirmation. The utilization of such genetically engineered organisms would offer the potential to curtail the necessity for culling animals of undesirable…
View article: Data from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
Data from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity Open
The recognition of the immune system as a key component of the tumor microenvironment (TME) led to promising therapeutics. Because such therapies benefit only subsets of patients, understanding the activities of immune cells in the TME is …
View article: Data from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
Data from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity Open
The recognition of the immune system as a key component of the tumor microenvironment (TME) led to promising therapeutics. Because such therapies benefit only subsets of patients, understanding the activities of immune cells in the TME is …
View article: Supplementary Data from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
Supplementary Data from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity Open
Supplementary Methods and Data- Changes are unmarked
View article: Supplementary Data from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
Supplementary Data from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity Open
Supplementary Methods and Data- Changes are unmarked
View article: Supplementary Tables from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
Supplementary Tables from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity Open
Supplementary tables
View article: Supplementary Tables from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
Supplementary Tables from Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity Open
Supplementary tables
View article: Adaptive immune response to BNT162b2 mRNA vaccine in immunocompromised adolescent patients
Adaptive immune response to BNT162b2 mRNA vaccine in immunocompromised adolescent patients Open
Protective immunity against COVID-19 is orchestrated by an intricate network of innate and adaptive anti-viral immune responses. Several vaccines have been rapidly developed to combat the destructive effects of COVID-19, which initiate an …
View article: CD300b regulates intestinal inflammation and promotes repair in colitis
CD300b regulates intestinal inflammation and promotes repair in colitis Open
Chronic inflammation is a hallmark charataristic of various inflammatory diseases including inflammatory bowel disease. Subsequently, current therapeutic approaches target immune-mediated pathways as means for therapeutic intervention and …
View article: Differential regulation of Type 1 and Type 2 mouse eosinophil activation by apoptotic cells
Differential regulation of Type 1 and Type 2 mouse eosinophil activation by apoptotic cells Open
Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a plethora of responses ranging from regulation of tissue homeostasis, host defense and cancer. Although eosinophils have been studied mostly in the co…
View article: Changes in peripheral blood eosinophils may predict colorectal cancer – A retrospective study
Changes in peripheral blood eosinophils may predict colorectal cancer – A retrospective study Open
View article: Epithelial cell‐expressed type <scp>II IL</scp>‐4 receptor mediates eosinophilic esophagitis
Epithelial cell‐expressed type <span>II IL</span>‐4 receptor mediates eosinophilic esophagitis Open
Background Eosinophilic esophagitis (EoE) is a chronic, food‐driven allergic disease, characterized by eosinophil‐rich inflammation in the esophagus. The histopathological and clinical features of EoE have been attributed to overproduction…
View article: Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy
Eosinophil–lymphocyte interactions in the tumor microenvironment and cancer immunotherapy Open
View article: Mouse resident lung eosinophils are dependent on <scp>IL</scp>‐5
Mouse resident lung eosinophils are dependent on <span>IL</span>‐5 Open
Eosinophils were traditionally considered terminally differentiated cells with little to no heterogeneity.1 Recent studies demonstrated that they can acquire unique phenotypes in response to diverse stimuli,1-3 and two subsets of eosinophi…
View article: Transcriptional Profiling of Mouse Eosinophils Identifies Distinct Gene Signatures Following Cellular Activation
Transcriptional Profiling of Mouse Eosinophils Identifies Distinct Gene Signatures Following Cellular Activation Open
Eosinophils are multifunctional, evolutionary conserved leukocytes that are involved in a plethora of responses ranging from regulation of tissue homeostasis to host defense and cancer. Eosinophils have been studied mostly in the context o…
View article: Editorial: Emerging Roles for Type 2-Associated Cells and Cytokines in Cancer Immunity
Editorial: Emerging Roles for Type 2-Associated Cells and Cytokines in Cancer Immunity Open
EDITORIAL article Front. Immunol., 26 November 2021Sec. Cancer Immunity and Immunotherapy Volume 12 - 2021 | https://doi.org/10.3389/fimmu.2021.811125
View article: Eosinophils in Health and Disease: A State-of-the-Art Review
Eosinophils in Health and Disease: A State-of-the-Art Review Open
Eosinophils play a homeostatic role in the body's immune responses. These cells are involved in combating some parasitic, bacterial, and viral infections and certain cancers and have pathologic roles in diseases including asthma, chronic r…
View article: Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity Open
The recognition of the immune system as a key component of the tumor microenvironment (TME) led to promising therapeutics. Because such therapies benefit only subsets of patients, understanding the activities of immune cells in the TME is …
View article: Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma Open
View article: Innate immune cells in the tumor microenvironment
Innate immune cells in the tumor microenvironment Open
View article: BNT162b2 vaccination effectively prevents the rapid rise of SARS-CoV-2 variant B.1.1.7 in high-risk populations in Israel
BNT162b2 vaccination effectively prevents the rapid rise of SARS-CoV-2 variant B.1.1.7 in high-risk populations in Israel Open
View article: The rise of SARS-CoV-2 variant B.1.1.7 in Israel intensifies the role of surveillance and vaccination in elderly
The rise of SARS-CoV-2 variant B.1.1.7 in Israel intensifies the role of surveillance and vaccination in elderly Open
Since the emergence of the SARS-CoV-2 pandemic various generic variants have been described. Of specific interest is a new variant, which was observed in England during December 2020 and is now termed B.1.1.7. This variant is now associate…
View article: Rapid seroconversion and persistent functional IgG antibodies in severe COVID-19 patients correlates with an IL-12p70 and IL-33 signature
Rapid seroconversion and persistent functional IgG antibodies in severe COVID-19 patients correlates with an IL-12p70 and IL-33 signature Open