Arielle Glatman Zaretsky
YOU?
Author Swipe
View article: ABS0060 UNDERSTANDING DRIVERS OF LUPUS PATHOGENESIS THROUGH COMPARISON OF PRECLINICAL MODELS
ABS0060 UNDERSTANDING DRIVERS OF LUPUS PATHOGENESIS THROUGH COMPARISON OF PRECLINICAL MODELS Open
View article: Structural insights into the assembly of gp130 family cytokine signaling complexes
Structural insights into the assembly of gp130 family cytokine signaling complexes Open
The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling receptor and play crucial roles in various cellular processes. We determined cryo–electron microscopy st…
View article: Infection-elicited microbiota promotes host adaptation to nutrient restriction
Infection-elicited microbiota promotes host adaptation to nutrient restriction Open
The microbiota performs multiple functions vital to host fitness, including defense against pathogens and adaptation to dietary changes. Yet, how environmental challenges shape microbiota resilience to nutrient fluctuation remains largely …
View article: Regulatory T cells as a therapeutic approach for inflammatory bowel disease
Regulatory T cells as a therapeutic approach for inflammatory bowel disease Open
Foxp3 + T regulatory (Treg) cells suppress inflammation and are essential for maintaining tissue homeostasis. A growing appreciation of tissue‐specific Treg functions has built interest in leveraging the endogenous suppressive mechanisms o…
View article: Cancer cell-derived type I interferons instruct tumor monocyte polarization
Cancer cell-derived type I interferons instruct tumor monocyte polarization Open
Monocytes are highly plastic immune cells that modulate antitumor immunity. Therefore, identifying factors that regulate tumor monocyte functions is critical for developing effective immunotherapies. Here, we determine that endogenous canc…
View article: Structural insights into the assembly of gp130 family cytokine signaling complexes
Structural insights into the assembly of gp130 family cytokine signaling complexes Open
The gp130 family cytokine signaling complexes have limited structural information despite their crucial roles in various cellular processes. We determined cryo-EM structures of several complexes of this family, containing full ectodomains …
View article: PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection
PD-L1–PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection Open
View article: White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection
White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection Open
View article: T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow
T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow Open
View article: Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity
Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity Open
View article: Diverse Roles for T-bet in the Effector Responses Required for Resistance to Infection
Diverse Roles for T-bet in the Effector Responses Required for Resistance to Infection Open
The transcription factor T-bet has been most prominently linked to NK and T cell production of IFN-γ, a cytokine required for the control of a diverse array of intracellular pathogens. Indeed, in mice challenged with the parasite Toxoplasm…