Arijita Chakraborty
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View article: Complex interplay between FMRP and DHX9 during DNA replication stress
Complex interplay between FMRP and DHX9 during DNA replication stress Open
Mutations in, or deficiency of, fragile X messenger ribonucleoprotein (FMRP) is responsible for the Fragile X syndrome (FXS), the most common cause for inherited intellectual disability. FMRP is a nucleocytoplasmic protein, primarily chara…
View article: Epigenomic signatures associated with spontaneous and replication stress-induced DNA double strand breaks
Epigenomic signatures associated with spontaneous and replication stress-induced DNA double strand breaks Open
Common fragile sites (CFSs) are specific regions of all individuals’ genome that are predisposed to DNA double strand breaks (DSBs) and undergo subsequent rearrangements. CFS formation can be induced in vitro by mild level of DNA replicati…
View article: FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase
FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase Open
The author has withdrawn this manuscript due to a duplicate posting of manuscript number 440759. Therefore, the author does not wish this work to be cited as reference for the project. If you have any questions, please contact the correspo…
View article: A Double Jeopardy: Loss of FMRP Results in DSB and Down-regulated DNA Repair.
A Double Jeopardy: Loss of FMRP Results in DSB and Down-regulated DNA Repair. Open
Our understanding of the molecular functions of the nucleocytoplasmic FMRP protein, which, if absent or dysfunctional, causes the fragile X syndrome (FXS), largely revolves around its involvement in protein translation regulation in the cy…
View article: A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation
A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation Open
R-loops are non-canonical, three-stranded nucleic acid structures composed of a DNA:RNA hybrid, a displaced single-stranded (ss)DNA, and a trailing ssRNA overhang. R-loops perform critical biological functions under both normal and disease…
View article: FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE
FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE Open
Mutations in, or deficiency of, FMRP is responsible for the Fragile X syndrome (FXS), the most common cause for inherited intellectual disability. FMRP is a nucleocytoplasmic protein, primarily characterized as a translation repressor with…
View article: Replication stress induces global chromosome breakage in the fragile X genome
Replication stress induces global chromosome breakage in the fragile X genome Open
(Cell Reports 32, 108179-1–108179–16.e1–e8; September 22, 2020) In the originally published version of this article, Carl L. Schildkraut was listed incorrectly in the author list. The corrected author list appears here and now with the art…
View article: R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast
R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast Open
This study from budding yeast provides mechanistic insights into how accumulation of R-loops at centromeric chromatin perturbs kinetochore integrity and contributes to chromosome instability.
View article: Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome Open
View article: Fragile X Mental Retardation Protein regulates R-loop formation and prevents global chromosome fragility
Fragile X Mental Retardation Protein regulates R-loop formation and prevents global chromosome fragility Open
Fragile X syndrome (FXS) is the most prevalent inherited intellectual disability caused by mutations in the Fragile X Mental Retardation 1 ( FMR1 ) gene. The protein product of FMR1 , FMRP, is known as a translational repressor whose nucle…