Arik Horne
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View article: Imaging neutron radiation-induced defects in single-crystal chemical vapor deposition diamond at the atomic level
Imaging neutron radiation-induced defects in single-crystal chemical vapor deposition diamond at the atomic level Open
Diamond's exceptional properties make it highly suited for applications in challenging radiation environments. Understanding radiation-induced damage in diamond is crucial for enabling its practical applications and advancing materials sci…
View article: Imaging Neutron Radiation-Induced Defects in Single-Crystal Chemical Vapor Deposition Diamond at the Atomic Level
Imaging Neutron Radiation-Induced Defects in Single-Crystal Chemical Vapor Deposition Diamond at the Atomic Level Open
View article: 4D-STEM Optical Sectioning of Dopants in Diamond
4D-STEM Optical Sectioning of Dopants in Diamond Open
View article: Identification of drug candidates targeting monocyte reprogramming in people living with HIV
Identification of drug candidates targeting monocyte reprogramming in people living with HIV Open
Introduction People living with HIV (PLHIV) are characterized by functional reprogramming of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess technical feasibility of omics technologies for applicat…
View article: Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia
Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia Open
View article: Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease Open
Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease …
View article: Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state
Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state Open
Omics-based technologies are driving major advances in precision medicine, but efforts are still required to consolidate their use in drug discovery. In this work, we exemplify the use of multi-omics to support the development of 3-chlorop…
View article: Author response: Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state
Author response: Decoding mechanism of action and sensitivity to drug candidates from integrated transcriptome and chromatin state Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Omics-based technologies are driving…
View article: Decoding mechanism of action and susceptibility to drug candidates from integrated transcriptome and chromatin state
Decoding mechanism of action and susceptibility to drug candidates from integrated transcriptome and chromatin state Open
Omics-based technologies are driving major advances in precision medicine but efforts are still required to consolidate their use in drug discovery. In this work, we exemplify the use of multi-omics to support the development of 3-chloropi…
View article: Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs
Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs Open
View article: Induction of peri-implantation stage synthetic embryos using reprogramming paradigms in ESCs
Induction of peri-implantation stage synthetic embryos using reprogramming paradigms in ESCs Open
Summary Blastocyst-derived stem cell lines were shown to self-organize into embryo-like structures in 3D cell culture environments. Here, we provide evidence that synthetic embryo-like structures are generated solely based on transcription…
View article: Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
View article: Additional file 1 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 1 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 1: Table S1. Cohort statistics.
View article: Additional file 3 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 3 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 3: Table S2. Differential genes.
View article: Additional file 8 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 8 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 8: Table S7. Drugs overview.
View article: Additional file 4 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 4 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 4: Table S3. CoCena modules.
View article: Additional file 9 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 9 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 9: Table S8. Differential genes of groups G1-G6.
View article: Additional file 10 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 10 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 10: Table S9. Predicted drugs.
View article: Additional file 5 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 5 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 5: Table S4. Granulocytes anno, differential genes and neutrophil subtypes.
View article: Additional file 6 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 6 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 6: Table S5. Overview of datasets.
View article: Additional file 7 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Additional file 7 of Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
Additional file 7: Table S6. Immune cell type signatures.
View article: Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment Open
View article: Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients Open
SUMMARY The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory di…
View article: Suppressive myeloid cells are a hallmark of severe COVID-19
Suppressive myeloid cells are a hallmark of severe COVID-19 Open
‘Severe Acute Respiratory Syndrome - Coronavirus-2’ (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract infection in the majority of patients. A subset of patients, however, progresses to…
View article: Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease
Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease Open
Despite the epidemics of chronic obstructive pulmonary disease (COPD), the cellular and molecular mechanisms of this disease are far from being understood. Here, we characterize and classify the cellular composition within the alveolar spa…
View article: Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke
Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke Open