Aris Kaltsas
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View article: Association Between Renal Cell Cancer and Chronic Kidney Disease: An Update on a Never-Healing Wound
Association Between Renal Cell Cancer and Chronic Kidney Disease: An Update on a Never-Healing Wound Open
The relationship between chronic kidney disease (CKD) and renal cell carcinoma (RCC) is both bidirectional and multifactorial. Several risk factors, including hypertension, diabetes mellitus, obesity, and smoking, have been associated with…
View article: Retained Intrarenal Guidewire Fragment After Endourological Stone Surgery: Antegrade Percutaneous Snare Retrieval and Literature Review
Retained Intrarenal Guidewire Fragment After Endourological Stone Surgery: Antegrade Percutaneous Snare Retrieval and Literature Review Open
Background and Clinical Significance: Retained intrarenal foreign bodies are rare adverse events after endourological stone surgery. Guidewire fracture or detachment is uncommon and can trigger infection, obstruction, or encrustation if un…
View article: Cystic Fibrosis and Male Infertility: From Genetics to Future Perspectives in Assisted Reproductive Technologies
Cystic Fibrosis and Male Infertility: From Genetics to Future Perspectives in Assisted Reproductive Technologies Open
Background/Objectives: Male infertility is a prevalent and often underrecognized manifestation of cystic fibrosis (CF), primarily caused by congenital bilateral absence of the vas deferens (CBAVD) due to CFTR gene mutations. With improved …
View article: Letrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review
Letrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review Open
Letrozole, a third-generation aromatase inhibitor initially developed for breast cancer, has become the preferred first-line agent for ovulation induction (OI), particularly in women with polycystic ovary syndrome (PCOS). This narrative re…
View article: Prostate Cancer Treatments and Their Effects on Male Fertility: Mechanisms and Mitigation Strategies
Prostate Cancer Treatments and Their Effects on Male Fertility: Mechanisms and Mitigation Strategies Open
Prostate cancer (PCa) is the second most frequently diagnosed malignancy in men worldwide. Although traditionally considered a disease of older men, the incidence of early-onset PCa (diagnosis < 55 years) is steadily rising. Advances in sc…
View article: Mitochondrial Dysregulation in Male Infertility: A Preliminary Study for Infertility-Specific lncRNA Variants
Mitochondrial Dysregulation in Male Infertility: A Preliminary Study for Infertility-Specific lncRNA Variants Open
Background/Objectives: Male infertility is a major health concern with a complex etiopathology, yet a substantial proportion of cases remain idiopathic. Mitochondrial dysfunction and non-coding RNA (ncRNA) deregulation have both been impli…
View article: Artificial Gametogenesis and In Vitro Spermatogenesis: Emerging Strategies for the Treatment of Male Infertility
Artificial Gametogenesis and In Vitro Spermatogenesis: Emerging Strategies for the Treatment of Male Infertility Open
Male-factor infertility accounts for approxiamately half of all infertility cases globally, yet therapeutic options remain limited for individuals with no retrievable spermatozoa, such as those with non-obstructive azoospermia (NOA). In re…
View article: Pelvic-ureteric junction obstruction due to fibroepithelial polyps – a rare case presentation and review of the literature
Pelvic-ureteric junction obstruction due to fibroepithelial polyps – a rare case presentation and review of the literature Open
View article: Successful Salvage of a Ruptured Testis Following Severe Blunt Trauma in a Polytrauma Patient
Successful Salvage of a Ruptured Testis Following Severe Blunt Trauma in a Polytrauma Patient Open
Testicular rupture is a rare but serious complication of blunt scrotal trauma, often linked to high-impact injuries. We report the case of a 20-year-old male with pelvic fractures and a high-riding right testis following a motorcycle accid…
View article: The Androbactome and the Gut Microbiota–Testis Axis: A Narrative Review of Emerging Insights into Male Fertility
The Androbactome and the Gut Microbiota–Testis Axis: A Narrative Review of Emerging Insights into Male Fertility Open
Male infertility is an under-recognized global health burden. Accumulating evidence position the intestinal microbiota as a pivotal regulator of testicular function, underpinning the emerging gut microbiota–testis axis. This narrative revi…
View article: To Rezūm or Not to Rezūm: A Narrative Review of Water Vapor Thermal Therapy for Benign Prostatic Hyperplasia
To Rezūm or Not to Rezūm: A Narrative Review of Water Vapor Thermal Therapy for Benign Prostatic Hyperplasia Open
Background/Objectives: Benign prostatic hyperplasia (BPH) is a common urological condition that can significantly impair quality of life in aging men by causing lower urinary tract symptoms (LUTS), including nocturia, weak stream, and inco…
View article: Comparative Study of Mono J Single-Step Versus Two-Step Balloon Nephrostomy Placement for Urinary Tract Obstruction: Efficiency, Tolerability, and Complication Rates
Comparative Study of Mono J Single-Step Versus Two-Step Balloon Nephrostomy Placement for Urinary Tract Obstruction: Efficiency, Tolerability, and Complication Rates Open
Background: Urinary tract obstruction can lead to severe renal impairment if not managed effectively. Nephrostomy placement is a critical intervention to relieve such obstructions. The aim of this study was to compare the mono J single-ste…
View article: Multi-Omics Perspectives on Testicular Aging: Unraveling Germline Dysregulation, Niche Dysfunction, and Epigenetic Remodeling
Multi-Omics Perspectives on Testicular Aging: Unraveling Germline Dysregulation, Niche Dysfunction, and Epigenetic Remodeling Open
Male reproductive aging proceeds gradually and involves complex alterations across germ cells, somatic cells, and the testicular niche. Multi-omics analyses highlight shifts in spermatogonial stem cell dynamics, diminished sperm quantity a…
View article: Male Infertility and Reduced Life Expectancy: Epidemiology, Mechanisms, and Clinical Implications
Male Infertility and Reduced Life Expectancy: Epidemiology, Mechanisms, and Clinical Implications Open
Male infertility is a prevalent condition affecting approximately 15% of couples worldwide. Recent evidence indicates that, beyond its immediate reproductive implications, male infertility may reflect broader health concerns. Large-scale c…
View article: Understanding Male Sexual Function after TESE or mTESE: A Narrative Review
Understanding Male Sexual Function after TESE or mTESE: A Narrative Review Open
Testicular sperm extraction (TESE) and microdissection TESE (mTESE) have revolutionized the treatment of male infertility, particularly in cases of non-obstructive azoospermia (NOA). These surgical techniques facilitate sperm retrieval for…
View article: Phospholipase Cζ, the Molecular Spark of Fertilization and Male Infertility: Insights from Bench to Bedside
Phospholipase Cζ, the Molecular Spark of Fertilization and Male Infertility: Insights from Bench to Bedside Open
Phospholipase C zeta (PLCζ) has emerged as a pivotal sperm-specific factor responsible for triggering oocyte activation, a process essential for successful fertilization and early embryogenesis. A narrative review was conducted to examine …
View article: CHANGES IN NOCTURNAL PENILE TUMESCENCE AND RIGIDITY AFTER LOW INTENSITY EXTRACORPOREAL SHOCKWAVE TREATMENT FOR ERECTILE DYSFUNCTION
CHANGES IN NOCTURNAL PENILE TUMESCENCE AND RIGIDITY AFTER LOW INTENSITY EXTRACORPOREAL SHOCKWAVE TREATMENT FOR ERECTILE DYSFUNCTION Open
Objectives Low-intensity extracorporeal shockwave therapy (Li-ESWT) is gaining attention as a potential treatment for erectile dysfunction (ED). Research indicates that Li-ESWT may promote new blood vessel growth, improving blood flow and …
View article: The Small RNA Landscape in Azoospermia: Implications for Male Infertility and Sperm Retrieval—A Preliminary Study
The Small RNA Landscape in Azoospermia: Implications for Male Infertility and Sperm Retrieval—A Preliminary Study Open
MicroRNAs (miRNAs), a class of small noncoding RNAs, play a crucial role in spermatogenesis. However, their specific expression patterns in azoospermic patients, particularly in relation to sperm presence and pregnancy outcomes, remain und…
View article: Primary Adenocarcinoma of the Upper Urinary Tract: A Systematic Review of the Literature on a Rare Entity
Primary Adenocarcinoma of the Upper Urinary Tract: A Systematic Review of the Literature on a Rare Entity Open
Background: Only a few published cases of primary adenocarcinoma of the upper urinary tract have been described in the literature. The aim of this systematic review was to collect all published cases of primary adenocarcinoma of the upper …
View article: Magnetic resonance imaging/ultrasound fusion-guided transperineal prostate biopsy: Protocol for a clinic-based surgical technique
Magnetic resonance imaging/ultrasound fusion-guided transperineal prostate biopsy: Protocol for a clinic-based surgical technique Open
Background: Prostate biopsy is a crucial diagnostic tool for detecting clinically significant prostate cancer (csPCa). Traditional transrectal ultrasound (TRUS)-guided biopsy methods are often associated with an increased infection risk of…
View article: Oxidative Stress in Benign Prostatic Hyperplasia: Mechanisms, Clinical Relevance and Therapeutic Perspectives
Oxidative Stress in Benign Prostatic Hyperplasia: Mechanisms, Clinical Relevance and Therapeutic Perspectives Open
Background/Objectives: Benign prostatic hyperplasia (BPH) is among the most common conditions affecting men as they age, resulting in lower urinary tract symptoms (LUTS) that can profoundly impact quality of life. While historically attrib…
View article: The Role of Gut Microbiota Dysbiosis in Erectile Dysfunction: From Pathophysiology to Treatment Strategies
The Role of Gut Microbiota Dysbiosis in Erectile Dysfunction: From Pathophysiology to Treatment Strategies Open
Erectile dysfunction (ED) is a prevalent male sexual disorder characterized by the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. While its etiology is multifactorial, encompassing v…
View article: Oxidative-Stress-Mediated Epigenetic Dysregulation in Spermatogenesis: Implications for Male Infertility and Offspring Health
Oxidative-Stress-Mediated Epigenetic Dysregulation in Spermatogenesis: Implications for Male Infertility and Offspring Health Open
Male reproductive health is governed by an intricate interplay of genetic, epigenetic, and environmental factors. Epigenetic mechanisms—encompassing DNA methylation, histone modifications, and non-coding RNA activity—are crucial both for s…
View article: Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management
Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management Open
Phosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as pivotal regulators of male reproductive physiology, exerting significant influence on testicular function, sperm maturation, and overall fertility poten…
View article: Comparative Impact of Microsurgical Varicocelectomy Versus Observation on Infertility in Infertile Men With Subclinical Varicocele
Comparative Impact of Microsurgical Varicocelectomy Versus Observation on Infertility in Infertile Men With Subclinical Varicocele Open
Although this study's small sample size limits its broader generalizability, its findings provide limited evidence that microsurgical ligation may modestly improve sperm morphology in men with subclinical varicocele. Further research with …
View article: The Effects of Transcutaneous Tibial Nerve Stimulation on Female Sexual Function in Multiple Sclerosis Patients: A Narrative Review
The Effects of Transcutaneous Tibial Nerve Stimulation on Female Sexual Function in Multiple Sclerosis Patients: A Narrative Review Open
Female sexual dysfunction (FSD) is prevalent among women with multiple sclerosis (MS), leading to significant impairments in quality of life. Despite various available treatments, current approaches often fail to address the complex, multi…
View article: Fusion MRI/Ultrasound-Guided Transperineal Biopsy: A Game Changer in Prostate Cancer Diagnosis
Fusion MRI/Ultrasound-Guided Transperineal Biopsy: A Game Changer in Prostate Cancer Diagnosis Open
Background/Objectives: Multiparametric-Magnetic Resonance Imaging(mp-MRI) presents the ability to detect clinically significant cancer, aiming to avoid biopsy if the results are negative or target an abnormal lesion if a suspected lesion o…
View article: Predictive Value of Varicocele Grade and Histopathology in Simultaneous Varicocelectomy and Sperm Retrieval in Non-Obstructive Azoospermia: A Retrospective Cohort Study
Predictive Value of Varicocele Grade and Histopathology in Simultaneous Varicocelectomy and Sperm Retrieval in Non-Obstructive Azoospermia: A Retrospective Cohort Study Open
Background and Objectives: Varicocele repair in men with non-obstructive azoospermia (NOA) remains a subject of debate due to inconsistent outcomes. This study aimed to evaluate the impact of microsurgical varicocelectomy on sperm recovery…
View article: Beta-Thalassemia and Male Infertility: Unraveling the Oxidative Stress Connection—An Up-to-Date Review
Beta-Thalassemia and Male Infertility: Unraveling the Oxidative Stress Connection—An Up-to-Date Review Open
Background/Objectives: Beta-thalassemia (BTH), a genetic disorder resulting from beta-globin gene mutations, affects over 1.5 million people globally. The disorder’s multifactorial impact on male fertility, particularly through oxidative s…
View article: Proteomics and Metabolomics in Varicocele-Associated Male Infertility: Advancing Precision Diagnostics and Therapy
Proteomics and Metabolomics in Varicocele-Associated Male Infertility: Advancing Precision Diagnostics and Therapy Open
Background/Objectives: Varicoceles are a common contributor to male infertility, significantly impacting male-factor infertility cases. Traditional diagnostic methods often lack the sensitivity to detect the molecular and cellular disrupti…