Aristotle N. Voineskos
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View article: “A Connected Community”: Evaluating the Use of Project ECHO to Support the Implementation of an Evidence-Based Early Psychosis Care Model
“A Connected Community”: Evaluating the Use of Project ECHO to Support the Implementation of an Evidence-Based Early Psychosis Care Model Open
Background and Hypothesis The Early Psychosis Intervention-Spreading Evidence-Based Treatment (EPI-SET) is a study evaluating the implementation and impact of NAVIGATE, a manualized model of care for first episode psychosis in geographical…
View article: In Vivo Cortical Microstructure: Relationships With Tauopathy and Cognitive Impairment in the Elderly
In Vivo Cortical Microstructure: Relationships With Tauopathy and Cognitive Impairment in the Elderly Open
Positron Emission Tomography (PET) of tau is considered “the” indicator of Alzheimer's pathology. However, non‐PET proxies would be helpful for wider accessibility. We used Neurite Orientation Dispersion and Density Imaging (NODDI)‐derived…
View article: Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations with Cognition and Functioning
Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations with Cognition and Functioning Open
Background Autism spectrum disorder (autism) and schizophrenia spectrum disorders (schizophrenia) exhibit overlapping social and neurocognitive impairment and considerable neurobiological heterogeneity. Blood-oxygen-level-dependent (BOLD) …
View article: Fidelity, Implementation Determinants, and Patient-Level Outcomes Following Initial Implementation of NAVIGATE in the Early Psychosis Intervention—Spreading Evidence-Based Treatment (EPI-SET) Study
Fidelity, Implementation Determinants, and Patient-Level Outcomes Following Initial Implementation of NAVIGATE in the Early Psychosis Intervention—Spreading Evidence-Based Treatment (EPI-SET) Study Open
Background and Hypothesis While early psychosis intervention (EPI) services are effective, care delivery is often inconsistent, particularly in recovery-oriented care. We hypothesized that facilitated implementation of NAVIGATE, an evidenc…
View article: Neuropsychiatric Symptoms Present Differently in Individuals with Different High-Risk States of Dementia
Neuropsychiatric Symptoms Present Differently in Individuals with Different High-Risk States of Dementia Open
Introduction: Neuropsychiatric symptoms (NPS) are common in neurocognitive disorders. However, the differences in presentation of NPS in high-risk states for dementia such as mild neurocognitive disorder (Mild NCD) and remitted major depre…
View article: Assessing Motor Cortex Excitability and Its Relationship with Cortical Atrophy in Alzheimer’s Dementia
Assessing Motor Cortex Excitability and Its Relationship with Cortical Atrophy in Alzheimer’s Dementia Open
Background: Cortical excitability has been proposed as a novel neurophysiological marker of neurodegeneration in Alzheimer’s dementia (AD). However, the link between cortical excitability and structural changes in AD is not well understood…
View article: Brain-cognition relationships and treatment outcome in treatment-resistant late-life depression
Brain-cognition relationships and treatment outcome in treatment-resistant late-life depression Open
View article: A longitudinal study of changes in depressive symptoms and risk factors for congestive heart failure
A longitudinal study of changes in depressive symptoms and risk factors for congestive heart failure Open
Background Depression is prevalent among patients with congestive heart failure (CHF) and is associated with increased mortality and healthcare use. However, most research on this association has focused on high-income countries, leaving a…
View article: Domain-specific associations between social cognition and aggression in schizophrenia spectrum disorders
Domain-specific associations between social cognition and aggression in schizophrenia spectrum disorders Open
Aggression in schizophrenia spectrum disorders (SSD) is rare but elevated relative to the general population. Existing studies have not identified reliable personal predictors of aggression in SSD. In line with social information processin…
View article: Designing digital conversational agents for youth with multiple mental health conditions: Insights on key features from a youth-engaged qualitative descriptive study
Designing digital conversational agents for youth with multiple mental health conditions: Insights on key features from a youth-engaged qualitative descriptive study Open
Objective This qualitative study aims to examine the key features and design elements of a mental health digital conversational agent (“Digital Conversational Agent” or “DCA”) for youth with multiple mental health conditions. Methods Twent…
View article: Comparative Analysis of Social Cognitive and Neurocognitive Performance Across Autism and Schizophrenia Spectrum Disorders
Comparative Analysis of Social Cognitive and Neurocognitive Performance Across Autism and Schizophrenia Spectrum Disorders Open
Background and Hypothesis Social cognitive and neurocognitive performance is impacted in autism and schizophrenia spectrum disorders (SSDs). Here, we compared social cognitive and neurocognitive performance across a large transdiagnostic s…
View article: Bayesian Optimization Of NeuroStimulation (BOONStim)
Bayesian Optimization Of NeuroStimulation (BOONStim) Open
View article: Investigating the impact of transcranial direct current stimulation (tDCS) on prevention of cognitive decline
Investigating the impact of transcranial direct current stimulation (tDCS) on prevention of cognitive decline Open
View article: Brain Structures and Cognitive Decline: Moderation Analysis of the Pact-Md Randomized Clinical Trial of Brain Stimulation Plus Cognitive Remediation Plus in Older Adults with Remitted Depression or Mild Cognitive Impairment
Brain Structures and Cognitive Decline: Moderation Analysis of the Pact-Md Randomized Clinical Trial of Brain Stimulation Plus Cognitive Remediation Plus in Older Adults with Remitted Depression or Mild Cognitive Impairment Open
View article: Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group
Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group Open
Background Schizophrenia (SCZ) is characterized by a disconnect from reality that manifests as various clinical and cognitive symptoms, and persistent neurobiological abnormalities. Sex-related differences in clinical presentation imply se…
View article: A longitudinal study of depressive symptom trajectories and risk factors in congestive heart failure
A longitudinal study of depressive symptom trajectories and risk factors in congestive heart failure Open
Background Depression is prevalent among patients with congestive heart failure (CHF) and is associated with increased mortality and healthcare utilization. However, most research has focused on high-income countries, leaving a gap in know…
View article: Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders
Task-based functional neural correlates of social cognition across autism and schizophrenia spectrum disorders Open
View article: A systematic review of structural and functional magnetic resonance imaging studies on the neurobiology of depressive symptoms in schizophrenia spectrum disorders
A systematic review of structural and functional magnetic resonance imaging studies on the neurobiology of depressive symptoms in schizophrenia spectrum disorders Open
Depressive symptoms in Schizophrenia Spectrum Disorders (SSDs) negatively impact suicidality, prognosis, and quality of life. Despite this, efficacious treatments are limited, largely because the neural mechanisms underlying depressive sym…
View article: Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Schizophrenia and Autism Spectrum Disorders
Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Schizophrenia and Autism Spectrum Disorders Open
Fractional amplitude of low-frequency fluctuation (fALFF) is a validated measure of resting-state spontaneous brain activity. Previous fALFF findings in autism and schizophrenia spectrum disorders (ASDs and SSDs) have been highly heterogen…
View article: Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods
Functional phenotypes in schizophrenia spectrum disorders: defining the constructs and identifying biopsychosocial correlates using data-driven methods Open
View article: A systematic review and meta-analysis of neuroimaging studies examining synaptic density in individuals with psychotic spectrum disorders
A systematic review and meta-analysis of neuroimaging studies examining synaptic density in individuals with psychotic spectrum disorders Open
Background Psychotic disorders have long been considered neurodevelopmental disorders where excessive synaptic pruning and cortical volume loss are central to disease pathology. We conducted a systematic review of the literature to identif…
View article: Mental Health Service Use Before First Diagnosis of a Psychotic Disorder
Mental Health Service Use Before First Diagnosis of a Psychotic Disorder Open
Importance Characterizing mental health service use trajectories preceding diagnosis of a psychotic disorder may help identify individuals at highest risk and in which settings they are at highest risk. Objective To examine mental health s…
View article: Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression
Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression Open
View article: Effect of dorsolateral prefrontal cortex structural measures on neuroplasticity and response to paired-associative stimulation in Alzheimer’s dementia
Effect of dorsolateral prefrontal cortex structural measures on neuroplasticity and response to paired-associative stimulation in Alzheimer’s dementia Open
Long-term potentiation (LTP)-like activity can be induced by stimulation protocols such as paired associative stimulation (PAS). We aimed to determine whether PAS-induced LTP-like activity (PAS-LTP) of the dorsolateral prefrontal cortex (D…
View article: <scp>SAN</scp> : Mitigating spatial covariance heterogeneity in cortical thickness data collected from multiple scanners or sites
<span>SAN</span> : Mitigating spatial covariance heterogeneity in cortical thickness data collected from multiple scanners or sites Open
In neuroimaging studies, combining data collected from multiple study sites or scanners is becoming common to increase the reproducibility of scientific discoveries. At the same time, unwanted variations arise by using different scanners (…
View article: MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume
MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume Open
Background/Objective. Enlarged lateral ventricle (LV) volume and decreased volume in the corpus callosum (CC) are hallmarks of schizophrenia (SZ). We previously showed an inverse correlation between LV and CC volumes in SZ, with glo…
View article: Cognitive function based on theta-gamma coupling vs. clinical diagnosis in older adults with mild cognitive impairment with or without major depressive disorder
Cognitive function based on theta-gamma coupling vs. clinical diagnosis in older adults with mild cognitive impairment with or without major depressive disorder Open
Whether individuals with mild cognitive impairment (MCI) and a history of major depressive disorder (MDD) are at a higher risk for cognitive decline than those with MCI alone is still not clear. Previous work suggests that a reduction in p…
View article: Bayesian Optimization of Neurostimulation (BOONStim)
Bayesian Optimization of Neurostimulation (BOONStim) Open
Background Transcranial magnetic stimulation (TMS) treatment response is influenced by individual variability in brain structure and function. Sophisticated, user-friendly approaches, incorporating both established functional magnetic reso…
View article: Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis
Heterogeneity in functional connectivity: Dimensional predictors of individual variability during rest and task fMRI in psychosis Open
View article: Bifactor models of psychopathology using multi‐informant and multi‐instrument dimensional measures in the ABCD study
Bifactor models of psychopathology using multi‐informant and multi‐instrument dimensional measures in the ABCD study Open
Background Due to limitations of categorical definitions of mental illness, there is a need for quantitative empirical investigations of the dimensional structure of psychopathology. Using exploratory bifactor methods, this study investiga…