Arit Ghosh
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View article: A novel isoform of tensin-1 promotes actin filament assembly for efficient erythroblast enucleation
A novel isoform of tensin-1 promotes actin filament assembly for efficient erythroblast enucleation Open
Mammalian red blood cells are generated via a terminal erythroid differentiation pathway culminating in cell polarization and enucleation. Actin filament (F-actin) polymerization is critical for enucleation, but the underlying molecular re…
View article: Elevated LDL-C induces T-cell metabolic dysfunction and increases inflammation and oxidative stress in midlife adults
Elevated LDL-C induces T-cell metabolic dysfunction and increases inflammation and oxidative stress in midlife adults Open
We evaluated the effect of low-density lipoprotein cholesterol (LDL-C) exposure on human T-cells isolated from midlife adults. T-cells were exposed to physiologically low and borderline high concentrations of LDL-C. We observed that high L…
View article: The<i>Legionella pneumophila</i>peptidoglycan recycling kinase, AmgK, is essential for survival and replication inside host alveolar macrophages
The<i>Legionella pneumophila</i>peptidoglycan recycling kinase, AmgK, is essential for survival and replication inside host alveolar macrophages Open
Bacterial cells are surrounded by a dynamic cell wall which in part is made up of a mesh-like peptidoglycan (PG) layer that provides the cell with structural integrity and resilience. In Gram-positive bacteria, this layer is thick and robu…
View article: A novel isoform of Tensin1 promotes actin filament assembly for efficient erythroblast enucleation
A novel isoform of Tensin1 promotes actin filament assembly for efficient erythroblast enucleation Open
Mammalian red blood cells are generated via a terminal erythroid differentiation pathway culminating in cell polarization and enucleation. Actin filament polymerization is critical for enucleation, but the molecular regulatory mechanisms r…
View article: A Short Isoform of Tensin1 Is a Novel Regulator of F-Actin Assembly in Human Erythroblasts That Promotes Enucleation
A Short Isoform of Tensin1 Is a Novel Regulator of F-Actin Assembly in Human Erythroblasts That Promotes Enucleation Open
Mammalian red blood cells (RBCs) are generated via a terminal erythroid differentiation pathway culminating in cell polarization and enucleation. Actin filament polymerization is critical for enucleation, with F-actin assembling into a pro…
View article: Minimalist Tetrazine <i>N</i>-Acetyl Muramic Acid Probes for Rapid and Efficient Labeling of Commensal and Pathogenic Peptidoglycans in Living Bacterial Culture and During Macrophage Invasion
Minimalist Tetrazine <i>N</i>-Acetyl Muramic Acid Probes for Rapid and Efficient Labeling of Commensal and Pathogenic Peptidoglycans in Living Bacterial Culture and During Macrophage Invasion Open
N-Acetyl muramic acid (NAM) probes containing alkyne or azide groups are commonly used to investigate aspects of cell wall synthesis because of their small size and ability to incorporate into bacterial peptidoglycan (PG). However, copper-…
View article: Erythroid differentiation in mouse erythroleukemia cells is driven via actin filament-tropomodulin3-tropomyosin networks
Erythroid differentiation in mouse erythroleukemia cells is driven via actin filament-tropomodulin3-tropomyosin networks Open
Erythroid differentiation (ED) is a complex cellular process entailing morphologically distinct maturation stages of erythroblasts during terminal differentiation. Studies of actin filament assembly and organization during terminal ED have…
View article: Heterotrimeric G-Protein Signaling Is Required for Cellulose Degradation in Neurospora crassa
Heterotrimeric G-Protein Signaling Is Required for Cellulose Degradation in Neurospora crassa Open
Filamentous fungi are critical for the recycling of plant litter in the biosphere by degrading lignocellulosic biomass into simpler compounds for metabolism. Both saprophytic and pathogenic fungi utilize plant cell wall-degrading enzymes t…
View article: Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease
Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease Open
Megakaryocytes (MKs), the precursor cells for platelets, migrate from the endosteal niche of the bone marrow (BM) toward the vasculature, extending proplatelets into sinusoids, where circulating blood progressively fragments them into plat…
View article: Genetic relationships between the RACK1 homolog cpc-2 and heterotrimeric G protein subunit genes in Neurospora crassa
Genetic relationships between the RACK1 homolog cpc-2 and heterotrimeric G protein subunit genes in Neurospora crassa Open
Receptor for Activated C Kinase-1 (RACK1) is a multifunctional eukaryotic scaffolding protein with a seven WD repeat structure. Among their many cellular roles, RACK1 homologs have been shown to serve as alternative Gβ subunits during hete…
View article: Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches
Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches Open
Previous genetic and biochemical studies from Saccharomyces cerevisiae have identified a critical ribosome-associated quality control complex (RQC) that facilitates resolution of stalled ribosomal complexes. While components of the mammali…
View article: Cellular Signaling Mechanisms in Neurospora crassa
Cellular Signaling Mechanisms in Neurospora crassa Open
Cellular signal transduction mechanisms are regulated at multiple different stages during an organism’s life cycle as well as life span. Environmental stress and starvation responses are extremely well coordinated by cell surface receptors…