Ariya Chindamporn
YOU?
Author Swipe
View article: Management of mould pneumonia in resource-limited settings in Asia: A Delphi-based consensus statement by the Asia Fungal Working Group
Management of mould pneumonia in resource-limited settings in Asia: A Delphi-based consensus statement by the Asia Fungal Working Group Open
Mould pneumonia can be life-threatening, and its incidence is increasing in Asia. Due to significant variability in diagnostic setups and the availability of antifungal agents, especially in resource-limited settings, the current treatment…
View article: Targeted long-read sequencing analysis and antifungal susceptibility profiles of Sporothrix schenckii isolates from Thailand
Targeted long-read sequencing analysis and antifungal susceptibility profiles of Sporothrix schenckii isolates from Thailand Open
Sporothrix spp. are dimorphic fungi capable of undergoing morphological changes in response to temperature variations. The genus Sporothrix includes the species S. schenckii sensu stricto , S. brasiliensis , S. globosa , and S. luriei that…
View article: Optimizing fungal DNA extraction and purification for Oxford Nanopore untargeted shotgun metagenomic sequencing from simulated hemoculture specimens
Optimizing fungal DNA extraction and purification for Oxford Nanopore untargeted shotgun metagenomic sequencing from simulated hemoculture specimens Open
Long-read metagenomics provides a promising alternative approach to fungal identification, circumventing methodological biases, associated with DNA amplification, which is a prerequisite for DNA barcoding/metabarcoding based on the primary…
View article: Enhancing knowledge of vascular pythiosis: Impact of a self-paced online course among Thai learners
Enhancing knowledge of vascular pythiosis: Impact of a self-paced online course among Thai learners Open
Background Pythiosis caused by Pythium insidiosum , is a rare but deadly infectious disease that is often underrecognized. The disease has high morbidity and mortality rates, particularly in vascular forms where surgical resection is neces…
View article: Exploring Fungal Abundance and WHO Fungal Priority Pathogens in Agricultural Fields: A One Health Perspective in Northeast Thailand
Exploring Fungal Abundance and WHO Fungal Priority Pathogens in Agricultural Fields: A One Health Perspective in Northeast Thailand Open
Fungal pathogens prevalent in agricultural areas pose a significant risk to human health, with some exhibiting high fatality rates, as reported by the WHO Fungal Pathogen Priority List (WHO FPPL). This study investigates fungal communities…
View article: Pythium insidiosum-antigen enhances neutrophil-mediated killing of zoospores
Pythium insidiosum-antigen enhances neutrophil-mediated killing of zoospores Open
Pythium insidiosum-antigen (PIA) immunotherapy has been used to treat human pythiosis. This study compared PIA-stimulated and unstimulated neutrophils on zoospore viability of P. insidiosum strains. We cultured and collected zoospores of 6…
View article: Development of lateral flow immunochromatographic assay with Anti-Pythium insidiosum antibodies for point-of-care testing of vascular pythiosis
Development of lateral flow immunochromatographic assay with Anti-Pythium insidiosum antibodies for point-of-care testing of vascular pythiosis Open
The pathogenic oomycete Pythium insidiosum causes a fatal infectious illness known as pythiosis, impacting humans and certain animals in numerous countries in the tropics and subtropics. Delayed diagnosis is a primary factor contributing t…
View article: Development of Lateral Flow Immunochromatographic Assay with Anti-Pythium insidiosum Antibodies for Point-of-Care Testing of Vascular Pythiosis
Development of Lateral Flow Immunochromatographic Assay with Anti-Pythium insidiosum Antibodies for Point-of-Care Testing of Vascular Pythiosis Open
The pathogenic oomycete Pythium insidiosum causes a fatal infectious illness known as pythiosis, impacting humans and certain animals in numerous countries in the tropics and subtropics. Delayed diagnosis is a primary factor contributing t…
View article: Needs assessment of a pythiosis continuing professional development program
Needs assessment of a pythiosis continuing professional development program Open
Background Pythiosis is a rare disease with high mortality, with over 94% of cases reported from Thailand and India. Prompt diagnosis and surgery improves patient outcomes. Therefore, continuing professional development (CPD) is essential …
View article: <i>Ex vivo</i> observation of <i>Pythium insidiosum</i> -antigen treated neutrophils on three <i>Pythium insidiosum</i> strains isolated from vascular pythiosis patients
<i>Ex vivo</i> observation of <i>Pythium insidiosum</i> -antigen treated neutrophils on three <i>Pythium insidiosum</i> strains isolated from vascular pythiosis patients Open
The mechanisms of Pythium insidiosum-antigen (PIA) immunotherapy activating a patient's immune system are unknown. We evaluated the interleukin-8 (IL-8) serum levels during P. insidiosum infection and after vaccination with PIA in vascular…
View article: Kazachstania pintolopesii in Blood and Intestinal Wall of Macrophage-Depleted Mice with Cecal Ligation and Puncture, the Control of Fungi by Macrophages during Sepsis
Kazachstania pintolopesii in Blood and Intestinal Wall of Macrophage-Depleted Mice with Cecal Ligation and Puncture, the Control of Fungi by Macrophages during Sepsis Open
Although macrophage depletion is a possible emerging therapeutic strategy for osteoporosis and melanoma, the lack of macrophage functions can lead to inappropriate microbial control, especially the regulation of intestinal microbiota. Ceca…
View article: 374. A Multicenter Open-Label Single-Arm Clinical Trial of Combination Therapy of Surgery, Itraconazole, Doxycycline, and Azithromycin for Vascular Pythiosis
374. A Multicenter Open-Label Single-Arm Clinical Trial of Combination Therapy of Surgery, Itraconazole, Doxycycline, and Azithromycin for Vascular Pythiosis Open
Background Vascular pythiosis, caused by Pythium insidiosum, is a neglected, life-threatening condition which carried a 100% mortality rate, within 3 months, among patients with residual disease after surgery, regardless of antifungal trea…
View article: Targeted sequencing analysis pipeline for species identification of human pathogenic fungi using long-read nanopore sequencing
Targeted sequencing analysis pipeline for species identification of human pathogenic fungi using long-read nanopore sequencing Open
Among molecular-based techniques for fungal identification, Sanger sequencing of the primary universal fungal DNA barcode, the internal transcribed spacer (ITS) region (ITS1, 5.8S, ITS2), is commonly used in clinical routine laboratories d…
View article: Neutrophil extracellular traps and phagocytosis in Pythium insidiosum
Neutrophil extracellular traps and phagocytosis in Pythium insidiosum Open
Neutrophils are innate immune cells that play crucial roles in response to extracellular pathogens, including bacteria and fungi. Pythium insidiosum ( P insidiosum ) is a fungus-like pathogen that causes "pythiosis" in mammals. This study …
View article: The current state of laboratory mycology in Asia/Pacific: A survey from the European Confederation of Medical Mycology (ECMM) and International Society for Human and Animal Mycology (ISHAM)
The current state of laboratory mycology in Asia/Pacific: A survey from the European Confederation of Medical Mycology (ECMM) and International Society for Human and Animal Mycology (ISHAM) Open
According to the replies provided, the resources available for IFI diagnosis and management vary among Asia/Pacific countries/territories. Economical or geographical factors may play a key role in the incidence and clinical handling of thi…
View article: Immunogenicity of SARS-CoV-2 vaccines in patients with multiple myeloma: a systematic review and meta-analysis
Immunogenicity of SARS-CoV-2 vaccines in patients with multiple myeloma: a systematic review and meta-analysis Open
Patients with multiple myeloma (MM) have a diminished immune response to coronavirus disease 2019 (COVID-19) vaccines. Risk factors for an impaired immune response are yet to be determined. We aimed to summarize the COVID-19 vaccine immuno…
View article: Beta-Glucan from S. cerevisiae Protected AOM-Induced Colon Cancer in cGAS-Deficient Mice Partly through Dectin-1-Manipulated Macrophage Cell Energy
Beta-Glucan from S. cerevisiae Protected AOM-Induced Colon Cancer in cGAS-Deficient Mice Partly through Dectin-1-Manipulated Macrophage Cell Energy Open
Although the impacts of Saccharomyces cerevisiae on cancers are mentioned, data on its use in mice with cyclic GMP-AMP synthase deficiency (cGAS-/-) are even rarer. Here, 12 weeks of oral administration of S. cerevisiae protected cGAS-/- m…
View article: P431 Tip to correct the variation position error in applying long-read high-throughput sequencing technology for fungal identification
P431 Tip to correct the variation position error in applying long-read high-throughput sequencing technology for fungal identification Open
Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Presently, long-read high-throughput sequencing technology has been started applying in the medical mycology field instead of common Sanger sequencing. With its capability to sequenc…
View article: P131 Optimization of MTT assay protocol in <i>Pythium insidiosum</i> zoospores incubated together with neutrophils
P131 Optimization of MTT assay protocol in <i>Pythium insidiosum</i> zoospores incubated together with neutrophils Open
Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives The tetrazolium-based MTT assay is widely used to assess cell viability. This colorimetric assay measures cell viability through the enzymatic reduction of MTT, a yellow w…
View article: M1.2 Human pythiosis
M1.2 Human pythiosis Open
Meet the expert session, September 22, 2022, 8:00 AM - 9:00 AM Human pythiosis is a rare, life-threatening infection, which is generally caused by Pythium insidiosum, a fungal-like oomycete. Four forms of human pythiosis are described: 1) …
View article: Helicobacter pylori, Protected from Antibiotics and Stresses Inside Candida albicans Vacuoles, Cause Gastritis in Mice
Helicobacter pylori, Protected from Antibiotics and Stresses Inside Candida albicans Vacuoles, Cause Gastritis in Mice Open
Due to (i) the simultaneous presence of Helicobacter pylori (ulcer-induced bacteria) and Candida albicans in the stomach and (ii) the possibility of prokaryotic–eukaryotic endosymbiosis (intravacuolar H. pylori in the yeast cells) under st…
View article: Role of Immunotherapy in Pythium insidiosum Keratitis
Role of Immunotherapy in Pythium insidiosum Keratitis Open
Pythium keratitis is a potentially devastating ocular condition. Incidence of Pythium keratitis has been reported in tropical and subtropical areas. In previous reports, there were no effective or standard treatments, and combinations of m…
View article: Macrophage depletion alters bacterial gut microbiota partly through fungal overgrowth in feces that worsens cecal ligation and puncture sepsis mice
Macrophage depletion alters bacterial gut microbiota partly through fungal overgrowth in feces that worsens cecal ligation and puncture sepsis mice Open
Because macrophage dysfunction from some emerging therapies might worsen gut-derived sepsis, cecal ligation and puncture (CLP) sepsis are performed in mice with clodronate-induced macrophage depletion. Macrophage depletion (non-sepsis) inc…
View article: Immunogenicity and Risk Factors Associated With Poor Humoral Immune Response of SARS-CoV-2 Vaccines in Recipients of Solid Organ Transplant
Immunogenicity and Risk Factors Associated With Poor Humoral Immune Response of SARS-CoV-2 Vaccines in Recipients of Solid Organ Transplant Open
In this systematic review and meta-analysis, the rates of positive antibody response in solid organ transplant recipients remained low despite multiple doses of mRNA vaccines. These findings suggest that more efforts are needed to modulate…
View article: A Review: Antimicrobial Therapy for Human Pythiosis
A Review: Antimicrobial Therapy for Human Pythiosis Open
Human pythiosis is associated with poor prognosis with significant mortality caused by Pythium insidiosum. Antimicrobials’ in vitro and in vivo results against P. insidiosum are inconsistent. Although antimicrobials are clinically useful, …
View article: Neutrophil Extracellular Traps in Severe SARS-CoV-2 Infection: A Possible Impact of LPS and (1→3)-β-D-glucan in Blood from Gut Translocation
Neutrophil Extracellular Traps in Severe SARS-CoV-2 Infection: A Possible Impact of LPS and (1→3)-β-D-glucan in Blood from Gut Translocation Open
Due to limited data on the link between gut barrier defects (leaky gut) and neutrophil extracellular traps (NETs) in coronavirus disease 2019 (COVID-19), blood samples of COVID-19 cases—mild (upper respiratory tract symptoms without pneumo…