Arjen M. Dondorp
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View article: Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated <i>Plasmodium falciparum</i> malaria
Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated <i>Plasmodium falciparum</i> malaria Open
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based com…
View article: Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial
Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial Open
Wellcome Trust through the COVID-19 Therapeutics Accelerator.
View article: Enhancing CYP2D6 genotyping with nanopore sequencing to address allele diversity P. vivax malaria elimination
Enhancing CYP2D6 genotyping with nanopore sequencing to address allele diversity P. vivax malaria elimination Open
The precise profiling of CYP2D6 alleles is critical for identifying patients who are likely to benefit from primaquine therapy, a standard treatment for preventing P. vivax relapse and, as a result, obstacle for malaria elimination. Conven…
View article: Can malaria rapid diagnostic tests be used to detect simian malaria?
Can malaria rapid diagnostic tests be used to detect simian malaria? Open
The performance of RDTs in detecting simian malaria varies according to RDT brand, infecting Plasmodium species, and parasite density. Most RDT brands show good performance to detect simian Plasmodium species when parasite density exceeds …
View article: Using the Observational Medical Outcomes Partnership Common Data Model for a multi-registry intensive care unit benchmarking federated analysis: lessons learned
Using the Observational Medical Outcomes Partnership Common Data Model for a multi-registry intensive care unit benchmarking federated analysis: lessons learned Open
Objective Federated analysis is a method that allows data analysis to be performed on similar datasets without exchanging any data, thus facilitating international research collaboration while adhering to strict privacy laws. This study ai…
View article: Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples
Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples Open
We describe the Pf8 data resource, the latest MalariaGEN release of curated genome variation data on over 33,000 Plasmodium falciparum samples from 99 partner studies and 122 locations over more than 50 years. This release provides open a…
View article: Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19
Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 Open
Background Ensitrelvir is an oral antiviral treatment for COVID-19 with the same molecular target as ritonavir-boosted nirmatrelvir - the current oral first-line treatment. There have been no direct comparisons between the two drugs. Metho…
View article: Genetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion
Genetic surveillance of Plasmodium falciparum populations following treatment policy revisions in the Greater Mekong Subregion Open
View article: Operational evaluation of the deployment of Malaria/CRP Duo and Dengue Duo rapid diagnostic tests for the management of febrile illness by village malaria workers in rural Cambodia
Operational evaluation of the deployment of Malaria/CRP Duo and Dengue Duo rapid diagnostic tests for the management of febrile illness by village malaria workers in rural Cambodia Open
Introduction The decline in malaria cases in Cambodia has led to a relative increase in non-malarial febrile illness. In rural Cambodia, village malaria workers (VMWs) provide early diagnosis and treatment for malaria, but their role and r…
View article: Co-designing the consent process of critical care trials with patients and the public: Project protocol
Co-designing the consent process of critical care trials with patients and the public: Project protocol Open
Background Informed consent processes in critical care trials can be overwhelming for patients and their families as decisions about participation need to be made under distressing circumstances. Existing consent processes have been develo…
View article: Correction: Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study
Correction: Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study Open
View article: Evaluation of the Establishment of a Public and Patient Involvement and Engagement Group to Support Clinical Trials in Pakistan: Protocol for a Mixed-Methods Study
Evaluation of the Establishment of a Public and Patient Involvement and Engagement Group to Support Clinical Trials in Pakistan: Protocol for a Mixed-Methods Study Open
Background Patient and public involvement and engagement (PPIE) in research is a collaboration between researchers, patients, and the public, enhancing research acceptability, relevance, and impact. There is a growing prevalence of PPIE in…
View article: Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study
Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study Open
Background Approximately half of all antimicrobial prescriptions in intensive care units (ICUs) may be inappropriate, including those prescribed when not needed, in unnecessary combinations or for longer durations than needed. Inappropriat…
View article: Dose‐Optimization of a Novel Co‐Formulated Triple Combination Antimalarial Therapy: Artemether‐Lumefantrine‐Amodiaquine
Dose‐Optimization of a Novel Co‐Formulated Triple Combination Antimalarial Therapy: Artemether‐Lumefantrine‐Amodiaquine Open
Artemisinin‐based combination therapy (ACT) is the first‐line therapy for uncomplicated falciparum malaria, but artemisinin resistance in Asia and now sub‐Saharan Africa is threatening our ability to control and eliminate malaria. Triple‐A…
View article: Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia
Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia Open
View article: Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)
Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV) Open
View article: The Accuracy of the Passive Leg Raising Test Using the Perfusion Index to Identify Preload Responsiveness—A Single Center Study in a Resource-Limited Setting
The Accuracy of the Passive Leg Raising Test Using the Perfusion Index to Identify Preload Responsiveness—A Single Center Study in a Resource-Limited Setting Open
Background: We investigated the accuracy of predicting preload responsiveness by means of a passive leg raising test (PLR) using the perfusion index (PI) in critically ill patients showing signs of hypoperfusion in a resource-limited setti…
View article: Effectiveness and Safety of High Dose Primaquine and Tafenoquine in Plasmodium vivax Patients (EFFORT) - A Multi-Centre, Open Label, Superiority Randomised Controlled Trial
Effectiveness and Safety of High Dose Primaquine and Tafenoquine in Plasmodium vivax Patients (EFFORT) - A Multi-Centre, Open Label, Superiority Randomised Controlled Trial Open
View article: Molecular analysis of <i>DHFR</i> and <i>DHPS</i> gene mutations in <i>Plasmodium cynomolgi</i> from humans and macaques in Southeast Asia
Molecular analysis of <i>DHFR</i> and <i>DHPS</i> gene mutations in <i>Plasmodium cynomolgi</i> from humans and macaques in Southeast Asia Open
Plasmodium cynomolgi is an emerging zoonotic malaria parasite in Southeast Asia, infecting both humans and macaques. In this study, we investigated mutations in the DHFR and DHPS genes of P. cynomolgi from humans and macaques, comparing th…
View article: Use of the Pragmatic-Explanatory Continuum Indicator Summary Tool in Low- and Middle-Income Country Settings: Systematic Review
Use of the Pragmatic-Explanatory Continuum Indicator Summary Tool in Low- and Middle-Income Country Settings: Systematic Review Open
View article: Malaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders
Malaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders Open
In countries approaching malaria elimination, resourcing community-based health workers could play a critical role in enhancing malaria surveillance, early case detection and treatment, including interventions targeting migrant populations…
View article: Artemether–lumefantrine–amodiaquine or artesunate–amodiaquine combined with single low-dose primaquine to reduce Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a five-arm, phase 2, single-blind, randomised controlled trial
Artemether–lumefantrine–amodiaquine or artesunate–amodiaquine combined with single low-dose primaquine to reduce Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a five-arm, phase 2, single-blind, randomised controlled trial Open
Bill & Melinda Gates Foundation.
View article: Regional action needed to halt antimalarial drug resistance in Africa
Regional action needed to halt antimalarial drug resistance in Africa Open
View article: Correction: Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages
Correction: Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages Open
[This corrects the article DOI: 10.1371/journal.pone.0283405.].
View article: Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background
Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background Open
View article: Suitability of low and middle-income country data-derived prognostics models for benchmarking mortality in a multinational Asia critical care registry network: a multicentre study
Suitability of low and middle-income country data-derived prognostics models for benchmarking mortality in a multinational Asia critical care registry network: a multicentre study Open
Background This study evaluates the predictive performance of prognostic models derived from low- and middle-income country (LMIC) data using a multinational Asian critical care dataset. The research also seeks to identify opportunities fo…
View article: Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis
Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis Open
Bill & Melinda Gates Foundation.
View article: The predictive capacity of biomarkers for clinical pulmonary oedema in patients with severe falciparum malaria is low: a prospective observational study
The predictive capacity of biomarkers for clinical pulmonary oedema in patients with severe falciparum malaria is low: a prospective observational study Open
Background Pulmonary oedema is a feared and difficult to predict complication of severe malaria that can emerge after start of antimalarial treatment. Proinflammatory mediators are thought to play a central role in its pathogenesis. Method…
View article: Correction: Understanding patient and family experiences of critical care in Bangladesh and India: What are the priority actions to promote person-centred care?
Correction: Understanding patient and family experiences of critical care in Bangladesh and India: What are the priority actions to promote person-centred care? Open
[This corrects the article DOI: 10.1371/journal.pgph.0003372.].
View article: Reduced Red Blood Cell Deformability in Vivax Malaria
Reduced Red Blood Cell Deformability in Vivax Malaria Open
Reduced deformability of both infected and uninfected red blood cells (RBCs) contributes to pathogenesis in Plasmodium falciparum malaria. Whole-blood RBC deformability (RBC-D) is not well characterized in Plasmodium vivax malaria. We used…