Arjun Devadas
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View article: Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition
Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition Open
Metazoan gene transcription by RNA polymerase II (Pol II) is regulated in the promoter-proximal region. Pol II can undergo termination in the promoter-proximal region but whether this can contribute to transcription regulation in cells rem…
View article: FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo
FACT maintains chromatin architecture and thereby stimulates RNA polymerase II pausing during transcription in vivo Open
Facilitates chromatin transcription (FACT) is a histone chaperone that supports transcription through chromatin in vitro, but its functional roles in vivo remain unclear. Here, we analyze the in vivo functions of FACT with the use of multi…