Arjun Modi
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View article: Figure S5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 5
View article: Figure S4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 4
View article: Figure S2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 2
View article: Figure S1 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S1 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 1
View article: Figure S3 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S3 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 3
View article: Supplementary Tables from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Supplementary Tables from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplemental Table 1 and 2
View article: Data from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Data from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Chimeric antigen receptor (CAR) T cells can effectively treat leukemias, but sustained antitumor responses can be hindered by a lack of CAR T-cell persistence. Cytotoxic effector T cells are short-lived, and establishment of CAR-T cells wi…
View article: Figure 6 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 6 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Single-chain IL7Rα signaling stimulates STAT5 activation in CAR-T cells. A, Schema of the compared T-cell conditions. A: CAR and sIL7; B: CAR with the distal IL7Rα domain; C: CAR with the proximal IL7Rα domain. B, Levels of STAT5 phosphory…
View article: Figure S5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 5
View article: Figure 7 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 7 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Single-chain proximal IL7Rα CAR-T cells have decreased in vivo antileukemia activity. A, Schematic of the xenograft model. On day 0, NSG mice were injected via tail vein with 1 × 106 CD123+ MV-4-11.ffLuc cells. In treatment groups, 2 × 106…
View article: Figure S4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 4
View article: Figure 2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
T cells with IL7 pathway activation expand and circulate in vivo. A, Schematic of experimental design. NSG mice were injected on day 0 with 107 T cells expressing a ffLuc reporter. BLI was conducted biweekly, and peripheral blood collected…
View article: Data from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Data from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Chimeric antigen receptor (CAR) T cells can effectively treat leukemias, but sustained antitumor responses can be hindered by a lack of CAR T-cell persistence. Cytotoxic effector T cells are short-lived, and establishment of CAR-T cells wi…
View article: Figure 1 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 1 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Human primary T cells can be engineered for stable IL7 pathway activation. A, Schematic of CCR and sIL7, as well as transgenes engineered into cells. B, Transduction efficiency of T cells engineered to express GFP only, IL7R + GFP, or to s…
View article: Figure 5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Hinge modifications do not improve antigen specificity of CD123-targeted chimeric IL7Rα. A, Amino acid sequences of hinge regions used in functional studies. B, Transduction efficiency measured using his-tagged rhCD123 binding of engineere…
View article: Figure S2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 2
View article: Figure S5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S5 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 5
View article: Figure 4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
CCR expression does not diminish CAR T-cell antitumor activity. A, Schematic of the xenograft model. On day 0, NSG mice were injected via tail vein with 1 × 106 CD123+ MV-4-11.ffLuc cells. In treatment groups, 2 × 106 T cells were administ…
View article: Supplementary Tables from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Supplementary Tables from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplemental Table 1 and 2
View article: Figure 7 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 7 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Single-chain proximal IL7Rα CAR-T cells have decreased in vivo antileukemia activity. A, Schematic of the xenograft model. On day 0, NSG mice were injected via tail vein with 1 × 106 CD123+ MV-4-11.ffLuc cells. In treatment groups, 2 × 106…
View article: Figure S4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 4
View article: Figure S3 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S3 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 3
View article: Figure S3 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S3 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 3
View article: Supplementary Tables from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Supplementary Tables from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplemental Table 1 and 2
View article: Figure 3 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 3 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
CD123-targeted CAR and CCR can be coexpressed with maintained functionality. A, Schematic showing CAR and CCR structures. B, Transduction efficiency measured using flow cytometric staining of Halo and SNAP tags. n = 3 to 6 unique T-cell do…
View article: Figure 2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
T cells with IL7 pathway activation expand and circulate in vivo. A, Schematic of experimental design. NSG mice were injected on day 0 with 107 T cells expressing a ffLuc reporter. BLI was conducted biweekly, and peripheral blood collected…
View article: Figure S2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S2 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 2
View article: Figure S1 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure S1 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Supplementary Figure 1
View article: Figure 4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 4 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
CCR expression does not diminish CAR T-cell antitumor activity. A, Schematic of the xenograft model. On day 0, NSG mice were injected via tail vein with 1 × 106 CD123+ MV-4-11.ffLuc cells. In treatment groups, 2 × 106 T cells were administ…
View article: Figure 6 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain
Figure 6 from Activation of Cell-Intrinsic Signaling in CAR-T Cells via a Chimeric IL7R Domain Open
Single-chain IL7Rα signaling stimulates STAT5 activation in CAR-T cells. A, Schema of the compared T-cell conditions. A: CAR and sIL7; B: CAR with the distal IL7Rα domain; C: CAR with the proximal IL7Rα domain. B, Levels of STAT5 phosphory…