Arjun Rajan
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View article: Molecular hallmarks of hydrocephalus
Molecular hallmarks of hydrocephalus Open
Hydrocephalus (HC) is a failure of brain and cerebrospinal fluid (CSF) homeostasis often associated with dilation of the CSF-filled ventricles (ventriculomegaly). Hallmarks of HC include aberrant CSF dynamics, neural stem cell dysfunction …
View article: Brain development and bioenergetic changes
Brain development and bioenergetic changes Open
Bioenergetics describe the biochemical processes responsible for energy supply in organisms. When these changes become dysregulated in brain development, multiple neurodevelopmental diseases can occur, implicating bioenergetics as key regu…
View article: CRISPR/Cas9 gene editing in<i>Drosophila</i>via visual selection in a summer classroom
CRISPR/Cas9 gene editing in<i>Drosophila</i>via visual selection in a summer classroom Open
CRISPR/Cas9 methods are a powerful in vivo approach to edit the genome of Drosophila melanogaster . To convert existing Drosophila GAL4 lines to LexA driver lines in a secondary school classroom setting, we applied the CRISPR-based genetic…
View article: A Peristaltic Pump to Improve Bladder Emptying and Irrigation in Patients Who Use Clean Intermittent Catheterization
A Peristaltic Pump to Improve Bladder Emptying and Irrigation in Patients Who Use Clean Intermittent Catheterization Open
Background: Neurogenic bladder patients who intermittently catheterize may have systems that drain slowly and incompletely. These limitations can lead to urinary tract infections and bladder stone formation and be time consuming. We hypoth…
View article: Simplified homology-assisted CRISPR for gene editing in <i>Drosophila</i>
Simplified homology-assisted CRISPR for gene editing in <i>Drosophila</i> Open
In vivo genome editing with clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 generates powerful tools to study gene regulation and function. We revised the homology-assisted CRISPR knock-in method to convert Drosophi…
View article: CRISPR/Cas9 gene editing to generate<i>Drosophila</i>LexA lines in secondary school classes
CRISPR/Cas9 gene editing to generate<i>Drosophila</i>LexA lines in secondary school classes Open
Genome editing in vivo with CRISPR/Cas9 generates powerful tools to study gene regulation and function. We developed CRISPR-based methods that permitted secondary school student scientists to convert Drosophila GAL4 lines to LexA lines. Ou…
View article: Low-level repressive histone marks fine-tune gene transcription in neural stem cells
Low-level repressive histone marks fine-tune gene transcription in neural stem cells Open
Coordinated regulation of gene activity by transcriptional and translational mechanisms poise stem cells for a timely cell-state transition during differentiation. Although important for all stemness-to-differentiation transitions, mechani…
View article: Author response: Low-level repressive histone marks fine-tune gene transcription in neural stem cells
Author response: Low-level repressive histone marks fine-tune gene transcription in neural stem cells Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abs…
View article: Generation of LexA enhancer-trap lines in <i>Drosophila</i> by an international scholastic network
Generation of LexA enhancer-trap lines in <i>Drosophila</i> by an international scholastic network Open
Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertion…
View article: An international scholastic network to generate LexA enhancer-trap lines for<i>Drosophila</i>
An international scholastic network to generate LexA enhancer-trap lines for<i>Drosophila</i> Open
Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertion…
View article: Low-level repressive histone marks fine-tune stemness gene transcription in neural stem cells
Low-level repressive histone marks fine-tune stemness gene transcription in neural stem cells Open
Coordinated regulation of stemness gene activity by transcriptional and translational mechanisms poise stem cells for a timely cell-state transition during differentiation. Although important for all stemness-to-differentiation transitions…
View article: Regulation of Neural Stem Cell Competency and Commitment during Indirect Neurogenesis
Regulation of Neural Stem Cell Competency and Commitment during Indirect Neurogenesis Open
Indirect neurogenesis, during which neural stem cells generate neurons through intermediate progenitors, drives the evolution of lissencephalic brains to gyrencephalic brains. The mechanisms that specify intermediate progenitor identity an…
View article: An Interscholastic Network To Generate LexA Enhancer Trap Lines in <i>Drosophila</i>
An Interscholastic Network To Generate LexA Enhancer Trap Lines in <i>Drosophila</i> Open
Binary expression systems like the LexA-LexAop system provide a powerful experimental tool kit to study gene and tissue function in developmental biology, neurobiology, and physiology. However, the number of well-defined LexA enhancer trap…
View article: An Interscholastic Network to Generate LexA Enhancer Trap Lines in<i>Drosophila</i>
An Interscholastic Network to Generate LexA Enhancer Trap Lines in<i>Drosophila</i> Open
Binary expression systems like the LexA-LexAop system provide a powerful experimental tool kit to study gene and tissue function in developmental biology, neurobiology and physiology. However, the number of well-defined LexA enhancer trap …
View article: An <i>In Vitro</i> Study to Evaluate and Compare the Hemocompatibility of Titanium and Zirconia Implant Materials after Sandblasted and Acid Etched Surface Treatment
An <i>In Vitro</i> Study to Evaluate and Compare the Hemocompatibility of Titanium and Zirconia Implant Materials after Sandblasted and Acid Etched Surface Treatment Open
The implant's success depends on its biocompatibility and its property of osseointegration. The adverse interaction between blood and the artificial surface is detected by the hemocompatibility test for medical materials, to know if the su…
View article: Bacterial Richness of Soil Samples from Southern New Hampshire
Bacterial Richness of Soil Samples from Southern New Hampshire Open
As DNA sequencing has become more popular, knowledge about the soil microbiome has expanded considerably. This technological advancement has led to a greatly increased understanding about the role of bacteria in soil. Previous studies have…