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View article: Author Correction: Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein
Author Correction: Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein Open
View article: Development of Viral-Vectored Vaccines and Virus Replicon Particle-Based Neutralisation Assay against Mayaro Virus
Development of Viral-Vectored Vaccines and Virus Replicon Particle-Based Neutralisation Assay against Mayaro Virus Open
Mayaro virus (MAYV) is an emerging alphavirus causing acute febrile illness associated with chronic polyarthralgia. Although MAYV is currently restricted to tropical regions in South America around the Amazon basin, it has the potential to…
View article: High-Throughput Platform for Detection of Neutralizing Antibodies Using Flavivirus Reporter Replicon Particles
High-Throughput Platform for Detection of Neutralizing Antibodies Using Flavivirus Reporter Replicon Particles Open
Flavivirus outbreaks require fast and reliable diagnostics that can be easily adapted to newly emerging and re-emerging flaviviruses. Due to the serological cross-reactivity among flavivirus antibodies, neutralization tests (NT) are consid…
View article: A Novel Bacteriophage with Broad Host Range against Clostridioides difficile Ribotype 078 Supports SlpA as the Likely Phage Receptor
A Novel Bacteriophage with Broad Host Range against Clostridioides difficile Ribotype 078 Supports SlpA as the Likely Phage Receptor Open
Research into phage therapy has seen a resurgence in recent years owing to growing concerns regarding antimicrobial resistance. Phage research for potential therapy against Clostridium difficile infection (CDI) is in its infancy, where an …
View article: A novel bacteriophage with broad host-range against <i>Clostridioides difficile</i> ribotype 078 elucidates the phage receptor
A novel bacteriophage with broad host-range against <i>Clostridioides difficile</i> ribotype 078 elucidates the phage receptor Open
Bacteriophage represent a promising option for the treatment of Clostridioides difficile (formerly Clostridium difficile ) infection (CDI), which at present relies on conventional antibiotic therapy. The specificity of bacteriophages shoul…
View article: Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018
Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018 Open
Clostridioides difficile toxin A (TcdA) and Toxin B (TcdB) trigger inflammasome activation with caspase-1 activation in cultured cells, which in turn induce the release of IL-6, IFN-γ, and IL-8. Release of these proinflammatory resp…