Arlene Hurley
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View article: Supplementary Table 3 from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening
Supplementary Table 3 from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening Open
List of compounds in the primary screen
View article: Data from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening
Data from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening Open
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little e…
View article: Supplementary Table 3 from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening
Supplementary Table 3 from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening Open
List of compounds in the primary screen
View article: Supplementary Figures and Data from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening
Supplementary Figures and Data from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening Open
Supplementary Figure 1 - 6 and Supplementary Tables 1, 2, and 4
View article: Data from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening
Data from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening Open
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little e…
View article: Supplementary Figures and Data from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening
Supplementary Figures and Data from Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening Open
Supplementary Figure 1 - 6 and Supplementary Tables 1, 2, and 4
View article: Temporal relations between peripheral and central arousals in good and poor sleepers
Temporal relations between peripheral and central arousals in good and poor sleepers Open
Good sleepers and patients with insomnia symptoms (poor sleepers) were tracked with two measures of arousal; conventional polysomnography (PSG) for electroencephalogram (EEG) assessed cortical arousals, and a peripheral arterial tonometry …
View article: Plasma microRNA Interindividual Variability in Healthy Individuals, Pregnant Women, and an Individual with a Stably Altered Neuroendocrine Phenotype
Plasma microRNA Interindividual Variability in Healthy Individuals, Pregnant Women, and an Individual with a Stably Altered Neuroendocrine Phenotype Open
Background Extracellular RNAs (exRNAs) in biofluids are amenable to quantitative analysis and proposed as noninvasive biomarkers for monitoring organ function. Cell-lineage-specific microRNAs (miRNAs) are present in plasma as soluble ribon…
View article: DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2
DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2 Open
To address the need for simple, safe, sensitive, and scalable SARS-CoV-2 tests, we validated and implemented a PCR test that uses a saliva collection kit use at home. Individuals self-collected 300 μl saliva in vials containing Darnell Roc…
View article: Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening
Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening Open
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little e…
View article: DRUL for School: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2
DRUL for School: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2 Open
To address the need for simple, safe, sensitive, and scalable SARS-CoV-2 tests, we validated and implemented a PCR test that uses a saliva collection kit use at home. Individuals self-collected 300 µl saliva in vials containing Darnell Roc…
View article: mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants Open
View article: mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants Open
To date severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 100 million individuals resulting in over two million deaths. Many vaccines are being deployed to prevent coronavirus disease 2019 (COVID-19) including …
View article: Evolution of antibody immunity to SARS-CoV-2
Evolution of antibody immunity to SARS-CoV-2 Open
View article: Persistent cellular immunity to SARS-CoV-2 infection
Persistent cellular immunity to SARS-CoV-2 infection Open
SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals, we measured T cell responses in paired samples obt…
View article: Persistent Cellular Immunity to SARS-CoV-2 Infection
Persistent Cellular Immunity to SARS-CoV-2 Infection Open
SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained…
View article: Evolution of Antibody Immunity to SARS-CoV-2
Evolution of Antibody Immunity to SARS-CoV-2 Open
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable levels of antibodies with neutral…
View article: Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies Open
View article: Convergent antibody responses to SARS-CoV-2 in convalescent individuals
Convergent antibody responses to SARS-CoV-2 in convalescent individuals Open
View article: A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations
A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations Open
View article: 4235 The Use of Checklists Throughout the Lifecourse of a Clinical Research Study: The Rockefeller University Checklist Suite
4235 The Use of Checklists Throughout the Lifecourse of a Clinical Research Study: The Rockefeller University Checklist Suite Open
OBJECTIVES/GOALS: We have developed a comprehensive Translational Research Navigation Program to guide investigators all the way from protocol development through study closure. As the program evolved, we initially developed organizational…
View article: Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies
Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies Open
Summary Neutralizing antibody responses to coronaviruses focus on the trimeric spike, with most against the receptor-binding domain (RBD). Here we characterized polyclonal IgGs and Fabs from COVID-19 convalescent individuals for recognitio…
View article: Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals
Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals Open
During the COVID-19 pandemic, SARS-CoV-2 infected millions of people and claimed hundreds of thousands of lives. Virus entry into cells depends on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S). Although there is no …
View article: Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity
Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity Open
SUMMARY Although there is no effective cure for chronic hepatitis B virus (HBV) infection, antibodies are protective and constitute clinical correlates of recovery from infection. To examine the human neutralizing antibody response to HBV …
View article: Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis
Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis Open
Extracellular mRNAs (ex-mRNAs) potentially supersede extracellular miRNAs (ex-miRNAs) and other RNA classes as biomarkers. We performed conventional small-RNA-sequencing (sRNA-seq) and sRNA-seq with T4 polynucleotide kinase (PNK) end-treat…
View article: Detection of circulating extracellular mRNAs by modified small RNA-sequencing analysis
Detection of circulating extracellular mRNAs by modified small RNA-sequencing analysis Open
Extracellular mRNAs (ex-mRNAs) potentially supersede extracellular miRNAs (ex-miRNAs) and other RNA classes as biomarkers. Here, we present a comprehensive extracellular RNA (exRNA) study in human blood circulation based on conventional sm…
View article: Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico Open
View article: Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers
Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers Open