Arlo Upton
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View article: The Persistence of Neutralising Antibodies up to 11 months after SARS-CoV-2 Infection in the Southern Region of New Zealand
The Persistence of Neutralising Antibodies up to 11 months after SARS-CoV-2 Infection in the Southern Region of New Zealand Open
Summary During the first wave of SARS-CoV-2 infection in New Zealand a cohort of 78 PCR-confirmed COVID-19 cases was recruited in the Southern District Health Board region. Here we report on this unique cohort nearly 1-year after infection…
View article: Comprehensive analysis of SARS‐CoV‐2 antibody dynamics in New Zealand
Comprehensive analysis of SARS‐CoV‐2 antibody dynamics in New Zealand Open
Objectives Circulating antibodies are important markers of previous infection and immunity. Questions remain with respect to the durability and functionality of SARS‐CoV‐2 antibodies. This study explored antibody responses in recovered COV…
View article: Comprehensive analysis of SARS-CoV-2 antibody dynamics in New Zealand
Comprehensive analysis of SARS-CoV-2 antibody dynamics in New Zealand Open
Objectives Circulating antibodies are important markers of previous infection and immunity. Questions remain with respect to the durability and functionality of SARS-CoV-2 antibodies. This study explored antibody responses in recovered COV…
View article: SARS-CoV-2 antibodies in the Southern Region of New Zealand, 2020
SARS-CoV-2 antibodies in the Southern Region of New Zealand, 2020 Open
Background During New Zealand’s first outbreak in early 2020 the Southern Region had the highest per capita SARS-CoV-2 infection rate. PCR testing was initially limited by a narrow case definition and limited laboratory capacity, so cases …
View article: Development and Evaluation of a New Triplex Immunoassay That Detects Group A <i>Streptococcus</i> Antibodies for the Diagnosis of Rheumatic Fever
Development and Evaluation of a New Triplex Immunoassay That Detects Group A <i>Streptococcus</i> Antibodies for the Diagnosis of Rheumatic Fever Open
Streptococcal serology is a cornerstone in the diagnosis of acute rheumatic fever (ARF), a postinfectious sequela associated with group A Streptococcus infection. Current tests that measure anti-streptolysin O (ASO) and anti-DNaseB (ADB) t…
View article: Distribution of Streptococcal Pharyngitis and Acute Rheumatic Fever, Auckland, New Zealand, 2010–2016
Distribution of Streptococcal Pharyngitis and Acute Rheumatic Fever, Auckland, New Zealand, 2010–2016 Open
Group A Streptococcus (GAS) pharyngitis is a key initiator of acute rheumatic fever (ARF). In New Zealand, ARF cases occur more frequently among persons of certain ethnic and socioeconomic groups. We compared GAS pharyngitis estimates (1,2…
View article: Faecal immunochemical tests for occult blood testing should not be used outside of bowel screening: an audit of a large general practice
Faecal immunochemical tests for occult blood testing should not be used outside of bowel screening: an audit of a large general practice Open
INTRODUCTION The faecal immunochemical test (FIT) detects small quantities of human haemoglobin in faeces. This test has increasingly become the screening tool of choice in bowel cancer screening programmes worldwide, including New Zealand…
View article: Pseudozyma aphidis endophthalmitis post-cataract operation: Case discussion and management
Pseudozyma aphidis endophthalmitis post-cataract operation: Case discussion and management Open
Fungal endophthalmitis is a rare, potentially blinding complication of cataract surgery. We report our approach to this previously unreported organism, that led to an excellent visual outcome. There are no specific guidelines for fungal en…
View article: Suboptimal performance of rotavirus testing in a vaccinated community population should prompt laboratories to review their rotavirus testing algorithms in response to changes in disease prevalence
Suboptimal performance of rotavirus testing in a vaccinated community population should prompt laboratories to review their rotavirus testing algorithms in response to changes in disease prevalence Open
Rotavirus vaccine has reduced disease prevalence in many countries. Consequently, we aimed to assess the reliability of a rotavirus immunoassay in the community population of Auckland and Northland, New Zealand. Between 22 October 2015 and…
View article: Comparative M-protein analysis of Streptococcus pyogenes from pharyngitis and skin infections in New Zealand: Implications for vaccine development
Comparative M-protein analysis of Streptococcus pyogenes from pharyngitis and skin infections in New Zealand: Implications for vaccine development Open
BACKGROUND:Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are responsible for a significant disease burden amongst Māori and Pacific populations in New Zealand (NZ). However, contemporary data are lacking regarding circulati…
View article: Additional file 1: Table S1. of Comparative M-protein analysis of Streptococcus pyogenes from pharyngitis and skin infections in New Zealand: Implications for vaccine development
Additional file 1: Table S1. of Comparative M-protein analysis of Streptococcus pyogenes from pharyngitis and skin infections in New Zealand: Implications for vaccine development Open
Group A streptococcal isolates and emm types included in this study. (XLSX 12 kb)
View article: Comparison of <i>illumigene</i> Group A Streptococcus Assay with Culture of Throat Swabs from Children with Sore Throats in the New Zealand School-Based Rheumatic Fever Prevention Program
Comparison of <i>illumigene</i> Group A Streptococcus Assay with Culture of Throat Swabs from Children with Sore Throats in the New Zealand School-Based Rheumatic Fever Prevention Program Open
Group A streptococcal (GAS) pharyngitis is a particularly important condition in areas of New Zealand where the incidence of acute rheumatic fever remains unacceptably high. Prompt diagnosis and treatment of GAS pharyngitis are cornerstone…