Arman Bashirova
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View article: Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules
Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules Open
View article: Impact of HLA class I functional divergence on HIV control
Impact of HLA class I functional divergence on HIV control Open
Heterozygosity of Human leukocyte antigen ( HLA ) class I genes is linked to beneficial outcomes after HIV infection, presumably through greater breadth of HIV epitope presentation and cytotoxic T cell response. Distinct allotype pairs, ho…
View article: Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load
Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load Open
Correction to: Nature https://doi.org/10.1038/s41586-023-06370-4 Published online 2 August 2023
In the version of the article originally published, the “Acknowledgements” section was missing the following funding statement:…
In the version of the article originally published, the “Acknowledgements” section was missing the following funding statement:…
View article: Africa-specific human genetic variation near CHD1L associates with HIV-1 load
Africa-specific human genetic variation near CHD1L associates with HIV-1 load Open
View article: HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses
HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses Open
View article: Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression
Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression Open
View article: Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans
Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans Open
The leukocyte immunoglobulin–like receptor ( LILR ) B3 and LILRA6 genes encode homologous myeloid inhibitory and activating orphan receptors, respectively. Both genes exhibit a strikingly high level of polymorphism at the amino acid level …
View article: Residues in HLA class I that Account for Variation of the HIV Host Response Distinctly Modulate Interactions with TCR and KIRs
Residues in HLA class I that Account for Variation of the HIV Host Response Distinctly Modulate Interactions with TCR and KIRs Open
Polymorphisms in human leukocyte antigen ( HLA ) genes strongly influence outcomes to HIV infection. However, the underlying mechanisms by which certain alleles mediate protection is not well understood. Here we systematically investigate …
View article: Genetic variation that determines<i>TAPBP</i>expression levels associates with the course of malaria in an HLA allotype-dependent manner
Genetic variation that determines<i>TAPBP</i>expression levels associates with the course of malaria in an HLA allotype-dependent manner Open
HLA class I (HLA-I) allotypes vary widely in their dependence on tapasin (TAPBP), an integral component of the peptide-loading complex, to present peptides on the cell surface. We identified two single-nucleotide polymorphisms that regulat…
View article: Population-specific diversity of the immunoglobulin constant heavy G chain (IGHG) genes
Population-specific diversity of the immunoglobulin constant heavy G chain (IGHG) genes Open
View article: Identification and Characterization of Antigen-Specific CD8+ T Cells Using Surface-Trapped TNF-α and Single-Cell Sequencing
Identification and Characterization of Antigen-Specific CD8+ T Cells Using Surface-Trapped TNF-α and Single-Cell Sequencing Open
CD8+ T cells are key mediators of antiviral and antitumor immunity. The isolation and study of Ag-specific CD8+ T cells, as well as mapping of their MHC restriction, has practical importance to the study of disease and the development of t…
View article: HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV
HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV Open
View article: Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses
Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses Open
View article: HLA tapasin independence: broader peptide repertoire and HIV control
HLA tapasin independence: broader peptide repertoire and HIV control Open
Significance HLA class I molecules bind antigenic peptides and present them on the cell surface to cytotoxic T cells to initiate immune responses. The peptide selection process occurs intracellularly with the aid of a molecule called tapas…
View article: IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody
IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody Open
Broadly neutralizing antibodies (bNAbs) protect against HIV infection in non-human primates and their efficacy may be enhanced through interaction with Fc receptors on immune cells. Antibody isotype is a modulator of this binding with the …
View article: Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load Open
Significance A proportion of the variation in HIV-1 viral load in the infected population is influenced by host genetics. Using a large sample of infected individuals ( n = 6,315) with genome-wide genotype data, we sought to map genomic re…
View article: Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat
Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat Open
The pharmaceutical reactivation of dormant HIV-1 proviruses by histone deacetylase inhibitors (HDACi) represents a possible strategy to reduce the reservoir of HIV-1-infected cells in individuals treated with suppressive combination antire…