Arman Öner
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View article: Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma
Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma Open
The success of targeted therapies for hematological malignancies has heralded their potential as both salvage treatment and early treatment lines, reducing the need for high-dose, intensive, and often toxic chemotherapeutic regimens. For y…
View article: PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells
PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells Open
Cancer-specific TCF1 + stem-like CD8 + T cells can drive protective anticancer immunity through expansion and effector cell differentiation 1–4 ; however, this response is dysfunctional in tumours. Current cancer immunotherapies 2,5–9 can …
View article: 10.01 Prostanoid-insensitive chimeric antigen receptor modified T cells mediate therapeutic efficacy in solid cancer models
10.01 Prostanoid-insensitive chimeric antigen receptor modified T cells mediate therapeutic efficacy in solid cancer models Open
Background Chimeric antigen receptor (CAR) T cell therapy has transformed the landscape of hematologic malignancy treatment. However, its successful translation to solid cancer treatment remains challenging, primarily due to the immunosupp…
View article: Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming
Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming Open
T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a pre…
View article: HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells
HIF-1α-mediated mitochondrial-glycolytic reprogramming controls the transition of precursor to terminally exhausted T cells Open
Functional exhaustion of T cells in cancer and persistent infections is characterized by the upregulation of inhibitory receptors, the progressive decline in cytokine secretion and impaired cytolytic activity. Terminally exhausted T cells …
View article: Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function
Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function Open
Background Chimeric antigen receptor (CAR) T cell therapy has been successfully translated to clinical practice for the treatment of B cell malignancies. The suppressive microenvironment of many malignancies is a bottleneck preventing trea…
View article: 10.01 Effective solid tumor therapy through enhanced recruitment and immune suppression shielded T cells
10.01 Effective solid tumor therapy through enhanced recruitment and immune suppression shielded T cells Open
Background CAR T cell therapy remains ineffective in solid tumors. Scarce T cell infiltration and T cell suppression at the tumor site are two notable therapy limitations. T regulatory (Treg) cells are capable of suppressing effective anti…
View article: P06.06 Enhancing trafficking and resistance to immunosuppression of synthetic agonistic receptor-transduced T cells in solid tumor models
P06.06 Enhancing trafficking and resistance to immunosuppression of synthetic agonistic receptor-transduced T cells in solid tumor models Open
Background Chimeric antigen receptor therapy – although very efficacious in B cell malignancies – is facing many challenges which limit its success in solid tumors, e.g. on-target off-tumor toxicities, antigen heterogeneity, lack of T cell…
View article: 10.03 Interleukin-22 regulates anti-tumor immunity in mouse models of lung and breast carcinoma
10.03 Interleukin-22 regulates anti-tumor immunity in mouse models of lung and breast carcinoma Open
Background High expression of CD155 (poliovirus receptor, PVR) is associated with a poor prognosis of lung adenocarcinoma (LUAD) and triple-negative breast cancer (TNBC) patients. When overexpressed, this molecule inhibits the antitumor fu…
View article: Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors
Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors Open
The combination of directed migration and immunosuppressive shielding enables effective T cell therapy in solid tumors.
View article: P06.01 Bispecific antibody-driven synthetic agonistic receptor – transduced T cells mediate specific and conditional therapy in melanoma cancer models
P06.01 Bispecific antibody-driven synthetic agonistic receptor – transduced T cells mediate specific and conditional therapy in melanoma cancer models Open
Background Immunotherapeutic approaches, including immune checkpoint blockade and adoptive T cell therapy (ACT) in the form of tumor-infiltrating lymphocytes (TILs), have had marked success in the treatment of melanoma. Despite these succe…