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View article: Moving Beyond Binary Biomarkers: Machine Learning Model Resolves Concurrent and Molecularly Heterogeneous Mismatch Repair and Homologous Recombination Deficiencies in Prostate Cancer
Moving Beyond Binary Biomarkers: Machine Learning Model Resolves Concurrent and Molecularly Heterogeneous Mismatch Repair and Homologous Recombination Deficiencies in Prostate Cancer Open
Current DNA damage repair (DDR) biomarkers employ binary classifications that fail to capture the molecular complexity of tumors with concurrent repair deficiencies. We used genomics analysis to stratify 672 metastatic prostate cancer pati…
View article: Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies Open
Genomic loss of the transcriptional kinase CDK12 occurs in ∼6% of metastatic castration-resistant prostate cancers (mCRPC) and correlates with poor patient outcomes. Prior studies demonstrate that acute CDK12 loss confers a homologous reco…
View article: Multiomic assessments of LNCaP and derived cell strains reveal determinants of prostate cancer pathobiology
Multiomic assessments of LNCaP and derived cell strains reveal determinants of prostate cancer pathobiology Open
A cornerstone of research to improve cancer outcomes involves studies of model systems to identify causal drivers of oncogenesis, understand mechanisms leading to metastases, and develop new therapeutics. Although most cancer types are rep…
View article: The molecular mechanism of ambrosin-induced cytotoxicity of human breast cancer and bladder cancer cells
The molecular mechanism of ambrosin-induced cytotoxicity of human breast cancer and bladder cancer cells Open
Sesquiterpene lactones (STL) are lipophilic compounds synthesized as secondary metabolites in species across the plant kingdom, most notably in the family Asteraceae. One STL, found in North African Ambrosia maritima (A. maritima), and Car…
View article: Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies Open
Genomic loss of the transcriptional kinase CDK12 occurs in ∼6% of metastatic castration-resistant prostate cancers (mCRPC) and correlates with poor patient outcomes. Prior studies demonstrate that acute CDK12 loss confers a homologous reco…
View article: Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies Open
Genomic loss of the transcriptional kinase CDK12 occurs in ∼6% of metastatic castration-resistant prostate cancers (mCRPC) and correlates with poor patient outcomes. Prior studies demonstrate that acute CDK12 loss confers a homologous reco…
View article: Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies Open
Genomic loss of the transcriptional kinase CDK12 occurs in ∼6% of metastatic castration-resistant prostate cancers (mCRPC) and correlates with poor patient outcomes. Prior studies demonstrate that acute CDK12 loss confers a homologous reco…
View article: P104 Upregulation of both APRIL and BAFF in systemic lupus erythematosus suggests non-redundant roles, further revealed by potent dual inhibition with povetacicept (TACI vTD-Fc; ALPN-303)
P104 Upregulation of both APRIL and BAFF in systemic lupus erythematosus suggests non-redundant roles, further revealed by potent dual inhibition with povetacicept (TACI vTD-Fc; ALPN-303) Open
Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as well as T cells and innate immune cells. …
View article: LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function
LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function Open
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation. However, some tumors un…
View article: First-in-Class NADH/Ubiquinone Oxidoreductase Core Subunit S7 (NDUFS7) Antagonist for the Treatment of Pancreatic Cancer
First-in-Class NADH/Ubiquinone Oxidoreductase Core Subunit S7 (NDUFS7) Antagonist for the Treatment of Pancreatic Cancer Open
Pancreatic cancer cells adapt to nutrient-scarce metabolic conditions by increasing their oxidative phosphorylation reserve to survive. Here, we present a first-in-class small-molecule NDUFS7 antagonist that inhibits oxidative phosphorylat…
View article: Figure S1 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S1 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Impact of drug concentration and kinase inhibitor selection on synergistic response (L3.6pl model)
View article: Figure S6 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S6 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
COX-2 expression at the RNA and protein levels
View article: Supplementary Figure from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer
Supplementary Figure from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer Open
Supplementary Figure from Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non–Small Cell Lung Cancer
View article: Data from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer
Data from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer Open
Splicing of the hTERT gene to produce the full-length (FL) transcript is necessary for telomerase enzyme activity and telomere-dependent cellular immortality in the majority of human tumors, including non–small cell lung cancer (NSCLC) cel…
View article: Figure S5 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S5 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Effects of trametinib and palbociclib alone and in combination on growth and expression of various signaling proteins
View article: Figure S1 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S1 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Impact of drug concentration and kinase inhibitor selection on synergistic response (L3.6pl model)
View article: Figure S2 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S2 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Effect of combination treatment on growth and protein expression in models eliciting high and low synergy scores
View article: Figure S4 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S4 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Effect of combination treatment on COX-2 and Pdcd4 expression
View article: Figure S2 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S2 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Effect of combination treatment on growth and protein expression in models eliciting high and low synergy scores
View article: Supplementary Figure from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer
Supplementary Figure from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer Open
Supplementary Figure from Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non–Small Cell Lung Cancer
View article: Figure S4 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S4 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Effect of combination treatment on COX-2 and Pdcd4 expression
View article: Supplementary Data from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer
Supplementary Data from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer Open
Supplementary Data from Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non–Small Cell Lung Cancer
View article: Data from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Data from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
The ineffectiveness of chemotherapy in patients with pancreatic cancer highlights a critical unmet need in pancreatic cancer therapy. Two commonly mutated genes in pancreatic cancer, KRAS and CDKN2A, have an incidence exceeding 90%, suppor…
View article: Data from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Data from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
The ineffectiveness of chemotherapy in patients with pancreatic cancer highlights a critical unmet need in pancreatic cancer therapy. Two commonly mutated genes in pancreatic cancer, KRAS and CDKN2A, have an incidence exceeding 90%, suppor…
View article: Figure S6 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S6 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
COX-2 expression at the RNA and protein levels
View article: Data from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer
Data from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer Open
Splicing of the hTERT gene to produce the full-length (FL) transcript is necessary for telomerase enzyme activity and telomere-dependent cellular immortality in the majority of human tumors, including non–small cell lung cancer (NSCLC) cel…
View article: Figure S3 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S3 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Evaluation of in vivo efficacy to the combination of trametinib and palbociclib in L3.6pl tumor-bearing animals
View article: Figure S5 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers
Figure S5 from Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers Open
Effects of trametinib and palbociclib alone and in combination on growth and expression of various signaling proteins
View article: Supplementary Figure from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer
Supplementary Figure from Intronic <i>Cis-</i>Element DR8 in <i>hTERT</i> Is Bound by Splicing Factor SF3B4 and Regulates <i>hTERT</i> Splicing in Non–Small Cell Lung Cancer Open
Supplementary Figure from Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non–Small Cell Lung Cancer