Bernardo Camacho
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View article: Large and small extracellular vesicles from Wharton’s jelly MSCs: Biophysics, function, and strategies to improve immunomodulation
Large and small extracellular vesicles from Wharton’s jelly MSCs: Biophysics, function, and strategies to improve immunomodulation Open
Extracellular vesicles (EVs) have emerged as mediators of immunosuppression and pro-regenerative processes, particularly through mesenchymal stromal cells (MSCs) across various disease models. Despite significant progress, there is still a…
View article: In Silico Design of miniACE2 Decoys with In Vitro Enhanced Neutralization Activity against SARS-CoV-2, Encompassing Omicron Subvariants
In Silico Design of miniACE2 Decoys with In Vitro Enhanced Neutralization Activity against SARS-CoV-2, Encompassing Omicron Subvariants Open
The COVID-19 pandemic has overwhelmed healthcare systems and triggered global economic downturns. While vaccines have reduced the lethality rate of SARS-CoV-2 to 0.9% as of October 2024, the continuous evolution of variants remains a signi…
View article: Comprehensive analysis of secretome and transcriptome stability of Wharton jelly mesenchymal stromal cells during good manufacturing practice-compliant production
Comprehensive analysis of secretome and transcriptome stability of Wharton jelly mesenchymal stromal cells during good manufacturing practice-compliant production Open
These findings highlight the potential of MACE-seq as a quality assessment tool for WJ-MSC-based therapies, ensuring their efficacy and safety in clinical applications. Importantly, MACE-seq demonstrated its value in characterizing WJ-MSC-…
View article: Exploring calcium-free alternatives in endochondral bone repair tested on In vivo trials - A review
Exploring calcium-free alternatives in endochondral bone repair tested on In vivo trials - A review Open
Bone repair via endochondral ossification is a complex process for the critical size reparation of bone defects. Tissue engineering strategies are being developed as alternative treatments to autografts or allografts. Most approaches to bo…
View article: An international review of the characteristics of viral nucleic acid‐amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT
An international review of the characteristics of viral nucleic acid‐amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT Open
Background and Objectives Nucleic acid‐amplification testing (NAT) is used for screening blood donations/donors for blood‐borne viruses. We reviewed global viral NAT characteristics and NAT‐yield confirmatory testing used by blood operator…
View article: International review of blood donation nucleic acid amplification testing
International review of blood donation nucleic acid amplification testing Open
Background and Objectives Nucleic acid amplification testing (NAT), in blood services context, is used for the detection of viral and parasite nucleic acids to reduce transfusion‐transmitted infections. This project reviewed NAT for screen…
View article: Next-generation treatments: Immunotherapy and advanced therapies for COVID-19
Next-generation treatments: Immunotherapy and advanced therapies for COVID-19 Open
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in 2019 following prior outbreaks of coronaviruses like SARS and MERS in recent decades, underscoring their high potential of infectivit…
View article: Technological search of patents for the identification of devices with potential use in Tumor-infiltrating lymphocytes (TILs) research
Technological search of patents for the identification of devices with potential use in Tumor-infiltrating lymphocytes (TILs) research Open
Tumor-infiltrating lymphocytes (TILs) is a type of adoptive cell therapy that addresses the challenges associated with cancer treatment. In this approach, T cells from a patient's tumor are harvested and stimulated to activate and expand t…
View article: Electrospun Scaffolds of Polylactic Acid, Collagen, and Amorphous Calcium Phosphate for Bone Repair
Electrospun Scaffolds of Polylactic Acid, Collagen, and Amorphous Calcium Phosphate for Bone Repair Open
Most electrospun scaffolds for bone tissue engineering typically use hydroxyapatite (HA) or beta tricalcium phosphate (β-TCP). However, the biological activity of these crystalline compounds can be limited due to their low solubility. Ther…
View article: Mesenchymal Stromal Cells from Perinatal Tissues as an Alternative for Ex Vivo Expansion of Hematopoietic Progenitor and Stem Cells from Umbilical Cord Blood
Mesenchymal Stromal Cells from Perinatal Tissues as an Alternative for Ex Vivo Expansion of Hematopoietic Progenitor and Stem Cells from Umbilical Cord Blood Open
Umbilical cord blood (UCB) serves as a source of hematopoietic stem and progenitor cells (HSPCs) utilized in the regeneration of hematopoietic and immune systems, forming a crucial part of the treatment for various benign and malignant hem…
View article: Antibacterial PVA/Chitosan/alginate/Meropenem-based hydrogel as a potential therapeutic strategy for chronic ulcers infections
Antibacterial PVA/Chitosan/alginate/Meropenem-based hydrogel as a potential therapeutic strategy for chronic ulcers infections Open
One of the most critical challenges when treating chronic wounds is proper infection control. Traditionally, antibiotics are administered in high doses to inhibit bacterial growth, but they usually adversely affect the patient's health. To…
View article: Anti-ROR1 CAR-T cells: Architecture and performance
Anti-ROR1 CAR-T cells: Architecture and performance Open
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a membrane receptor that plays a key role in development. It is highly expressed during the embryonic stage and relatively low in some normal adult tissues. Malignancies such as…
View article: Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing
Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing Open
The HLA compatibility continues to be the main limitation when finding compatible donors, especially if an identical match is not found within the patient’s family group. The creation of bone marrow registries allowed a therapeutic option …
View article: CAR-T Cell Performance: How to Improve Their Persistence?
CAR-T Cell Performance: How to Improve Their Persistence? Open
Adoptive cell therapy with T cells reprogrammed to express chimeric antigen receptors (CAR-T cells) has been highly successful in patients with hematological neoplasms. However, its therapeutic benefits have been limited in solid tumor cas…
View article: Additional file 1 of Safety and efficacy of convalescent plasma for severe COVID-19: a randomized, single blinded, parallel, controlled clinical study
Additional file 1 of Safety and efficacy of convalescent plasma for severe COVID-19: a randomized, single blinded, parallel, controlled clinical study Open
Additional file 1. Lineages and mutations of interest in the studied population.
View article: Clinical Outcomes of Unrelated Umbilical Cord Blood Graft vs. Haploidentical Donor Transplantation: Critical Issues for an Adequate Comparison
Clinical Outcomes of Unrelated Umbilical Cord Blood Graft vs. Haploidentical Donor Transplantation: Critical Issues for an Adequate Comparison Open
Unrelated umbilical cord blood (UCB) and haploidentical grafts have been used for allogeneic hematopoietic stem and progenitor cell (HSPC) transplantation in patients without a related or non-related human leukocyte antigen (HLA)-matched d…
View article: The novel <i>HLA‐A*24</i> allele, <i>HLA‐A*24:487</i>, identified in three unrelated bone marrow donors in Colombia
The novel <i>HLA‐A*24</i> allele, <i>HLA‐A*24:487</i>, identified in three unrelated bone marrow donors in Colombia Open
Identification of the novel HLA‐A*24:487 allele, which differs from HLA‐A*24:02:01:01 at one position.
View article: Anaphylaxis and COVID-19 vaccines: Real-time interest using Google Trends
Anaphylaxis and COVID-19 vaccines: Real-time interest using Google Trends Open
International audience
View article: COVID-19 convalescent plasma composition and immunological effects in severe patients
COVID-19 convalescent plasma composition and immunological effects in severe patients Open
Convalescent plasma (CP) has emerged as a treatment for COVID-19. However, the composition and mechanism of action are not fully known. Therefore, we undertook a two-phase controlled study in which, first the immunological and metabolomic …
View article: Integrated Analysis of Transcriptome and Secretome From Umbilical Cord Mesenchymal Stromal Cells Reveal New Mechanisms for the Modulation of Inflammation and Immune Activation
Integrated Analysis of Transcriptome and Secretome From Umbilical Cord Mesenchymal Stromal Cells Reveal New Mechanisms for the Modulation of Inflammation and Immune Activation Open
Mesenchymal stromal cells (MSC) have been used in over 800 clinical trials with encouraging results in the field of transplant medicine and chronic inflammatory diseases. Today, Umbilical Cord (UC)-derived MSC are the second leading source…
View article: Efficient Non-Viral Gene Modification of Mesenchymal Stromal Cells from Umbilical Cord Wharton’s Jelly with Polyethylenimine
Efficient Non-Viral Gene Modification of Mesenchymal Stromal Cells from Umbilical Cord Wharton’s Jelly with Polyethylenimine Open
Mesenchymal stromal cells (MSC) derived from human umbilical cord Wharton’s jelly (WJ) have a wide therapeutic potential in cell therapy and tissue engineering because of their multipotential capacity, which can be reinforced through gene …
View article: Human Platelet Lysate Supports Efficient Expansion and Stability of Wharton’s Jelly Mesenchymal Stromal Cells via Active Uptake and Release of Soluble Regenerative Factors
Human Platelet Lysate Supports Efficient Expansion and Stability of Wharton’s Jelly Mesenchymal Stromal Cells via Active Uptake and Release of Soluble Regenerative Factors Open
Manufacturing of mesenchymal stromal cell (MSC)-based therapies for regenerative medicine requires the use of suitable supply of growth factors that enhance proliferation, cell stability and potency during cell expansion. Human blood deriv…
View article: Wharton’s Jelly-derived mesenchymal stromal cells retain their immunophenotype and immunomodulating characteristics after transfection with polyethylenimine
Wharton’s Jelly-derived mesenchymal stromal cells retain their immunophenotype and immunomodulating characteristics after transfection with polyethylenimine Open
Background Wharton’s Jelly-derived mesenchymal stromal cells (WJ-MSCs) present several advantages over other sources of multipotent stem cells, not only because they are obtained from neonatal umbilical cord, which is considered a biologic…