Armando D. Pardillo
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View article: Disruption of Hydrogen Bonding Network Decreases Catalytic Diversity of Chloroperoxidase via Abolishing Both Chlorination and Dismutation Activities
Disruption of Hydrogen Bonding Network Decreases Catalytic Diversity of Chloroperoxidase via Abolishing Both Chlorination and Dismutation Activities Open
The perpendicular orientation of the proximal alpha helix to the heme plane in chloroperoxidase (CPO) maximizes the influence of its intrinsic helix dipole that has been shown to reduce the “push-effect”, thereby increasing the heme redox …
View article: The Influence of the Proximal Amide Hydrogen Bonds and the Proximal Helix Dipole on the Catalytic Activity of Chloroperoxidase
The Influence of the Proximal Amide Hydrogen Bonds and the Proximal Helix Dipole on the Catalytic Activity of Chloroperoxidase Open
Chloroperoxidase (CPO) is a heme-thiolate protein with exceptional versatility and great potential as a biocatalyst. The CPO reactive species, Compound I ( Cpd I) is of particular interest, as well as the Cytochrome P450 (P450) -type monox…