Armel Jackson Seukep
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View article: Cadmium Exposure and Hepato-renal Injury in Response to Cigarette Smoking in Apparently Healthy Active Smokers in Buea-Cameroon
Cadmium Exposure and Hepato-renal Injury in Response to Cigarette Smoking in Apparently Healthy Active Smokers in Buea-Cameroon Open
Cigarette smoking in developing countries like Cameroon is increasing with unspecified exposure levels to cadmium, a known toxic chemical. This study conducted in Buea (Southwest Region, Cameroon) aimed to estimate the risk exposure to cad…
View article: Mechanistic Insights into the Inhibition of Recombinant Hepatitis E Virus Papain-like Cysteine Protease by <i>Khaya grandifoliola</i> Hydro-Ethanolic Extract: UHPLC-MS Profiling, Enzyme Kinetics, Computational Modeling, and Cell-Based Assays
Mechanistic Insights into the Inhibition of Recombinant Hepatitis E Virus Papain-like Cysteine Protease by <i>Khaya grandifoliola</i> Hydro-Ethanolic Extract: UHPLC-MS Profiling, Enzyme Kinetics, Computational Modeling, and Cell-Based Assays Open
Ethnopharmacological Relevance Hepatitis E virus (HEV), a significant cause of liver diseases, lacks specific treatments. Khaya grandifoliola C.DC (Meliaceae), used in ethnomedicine to treat infections and liver-related ailments, shows pro…
View article: Antioxidant enzyme activity, lipid peroxidation, and glycemic control among patients with type 2 diabetes mellitus in Buea Regional Hospital, Cameroon: A hospital-based case-control study
Antioxidant enzyme activity, lipid peroxidation, and glycemic control among patients with type 2 diabetes mellitus in Buea Regional Hospital, Cameroon: A hospital-based case-control study Open
Background Oxidative stress has been suggested to play a role in the pathogenesis of type 2 diabetes mellitus (T2DM) and development of complications by altering antioxidant levels and inducing lipid peroxidation. Although diabetes mellitu…
View article: Abnormal serum levels of liver enzyme markers and related risk factors in type 2 diabetes mellitus patients attending the Buea Regional Hospital, Cameroon
Abnormal serum levels of liver enzyme markers and related risk factors in type 2 diabetes mellitus patients attending the Buea Regional Hospital, Cameroon Open
The prevalence of type 2 Diabetes Mellitus (T2DM) is increasing globally. Besides the traditional complications associated with T2DM, such as diabetic retinopathy, neuropathy, and kidney diseases, new complications including liver diseases…
View article: Serological evidence and factors associated to liver damage in malaria-typhoid infected patients consulting in two health facilities, Yaoundé-Cameroon
Serological evidence and factors associated to liver damage in malaria-typhoid infected patients consulting in two health facilities, Yaoundé-Cameroon Open
Malaria and typhoid fever remain major health issues in developing countries like Cameroon, with frequent co-infections. The potential liver damage caused by their respective causative pathogens is overlooked in health management, posing a…
View article: Abnormal Serum Levels of Liver Enzyme Markers and Related Risk Factors in Type 2 Diabetes Mellitus Patients Attending the Buea Regional Hospital, Cameroon
Abnormal Serum Levels of Liver Enzyme Markers and Related Risk Factors in Type 2 Diabetes Mellitus Patients Attending the Buea Regional Hospital, Cameroon Open
Objectives: The prevalence of type 2 Diabetes Mellitus (T2DM) is increasing globally, leading to complications, including liver damage. This study aims to examine serum biomarkers of liver injury and the related risk factors in T2DM patien…
View article: Potential of methanol extracts of Nephelium lappaceum (Sapindaceae) and Hyphaene thebaica (Arecaceae) as adjuvants to enhance the efficacy of antibiotics against critical class priority bacteria
Potential of methanol extracts of Nephelium lappaceum (Sapindaceae) and Hyphaene thebaica (Arecaceae) as adjuvants to enhance the efficacy of antibiotics against critical class priority bacteria Open
Botanicals have shown promise in mitigating antibiotic resistance in bacteria. This study examined the efficacy of methanolic extracts from two food plants ( Nephelium lappaceum and Hyphaene thebaica ), alone and in combination with antibi…
View article: In Vitro Antibacterial Potential of Herbal Beverage Extracts From Cinnamon, Clove, and Thyme and Their Interactive Antimicrobial Profile With Selected Antibiotics Against Drug‐Resistant Clinical Pathogens
In Vitro Antibacterial Potential of Herbal Beverage Extracts From Cinnamon, Clove, and Thyme and Their Interactive Antimicrobial Profile With Selected Antibiotics Against Drug‐Resistant Clinical Pathogens Open
The increase in antibiotic resistance has increased the demand for new and safe therapeutic options. Herbal beverages, whether used alone or combined with standard antibiotics, have shown promise in combating drug‐resistant bacteria. This …
View article: Prevalence of hepatitis B and associated factors in the Buea Regional Hospital, Cameroon
Prevalence of hepatitis B and associated factors in the Buea Regional Hospital, Cameroon Open
View article: Unveiling the antibacterial potential and antibiotic-resistance breaker activity of Syzygium jambos (Myrtaceae) towards critical-class priority pathogen Klebsiella isolates
Unveiling the antibacterial potential and antibiotic-resistance breaker activity of Syzygium jambos (Myrtaceae) towards critical-class priority pathogen Klebsiella isolates Open
Background: Klebsiella has developed multiple-drug resistance (MDR) to a wide range of medicines, including carbapenems and third generation cephalosporins which are often regarded as the most effective drugs against MDR bacteria. The pres…
View article: Exploring Mangifera indica (Anacardiaceae) leaf and bark methanol extracts as potential adjuvant therapy in the management of multidrug-resistant Staphylococcus aureus
Exploring Mangifera indica (Anacardiaceae) leaf and bark methanol extracts as potential adjuvant therapy in the management of multidrug-resistant Staphylococcus aureus Open
Background: After several decades of antibiotic use, pathogenic bacteria have reached alarming levels of resistance. Staphylococcus aureus is the most common cause of nosocomial infections, and treatment is difficult owing to the advent of…
View article: Psidium guajava (Myrtaceae) re-sensitizes multidrug-resistant Pseudomonas aeruginosa over-expressing MexAB-OprM efflux pumps to commonly prescribed antibiotics
Psidium guajava (Myrtaceae) re-sensitizes multidrug-resistant Pseudomonas aeruginosa over-expressing MexAB-OprM efflux pumps to commonly prescribed antibiotics Open
Background: Pseudomonas aeruginosa is a critical-class priority pathogen showing high resistance to almost all classes of conventional antibiotics. As a result, discovering new drugs capable of combating Pseudomonas infections becomes crit…
View article: Aporphine alkaloids identified from Xylopia aethiopica and their potential hypoglycemic and hypolipidemic activities
Aporphine alkaloids identified from Xylopia aethiopica and their potential hypoglycemic and hypolipidemic activities Open
Xylopia aethiopica has been widely utilized as food condiments in West African countries, as well as traditional medicine for diabetes, but the responsible components remain unknown. In this work, the probable active components in the cont…
View article: What Approaches to Thwart Bacterial Efflux Pumps-Mediated Resistance?
What Approaches to Thwart Bacterial Efflux Pumps-Mediated Resistance? Open
An effective response that combines prevention and treatment is still the most anticipated solution to the increasing incidence of antimicrobial resistance (AMR). As the phenomenon continues to evolve, AMR is driving an escalation of hard-…
View article: Prevalence of unrecognized or “silent” myocardial ischemia in chronic kidney disease patients: Protocol for a systematic review and meta-analysis
Prevalence of unrecognized or “silent” myocardial ischemia in chronic kidney disease patients: Protocol for a systematic review and meta-analysis Open
Introduction Chronic kidney disease (CKD) patients are at an extremely high risk of silent myocardial ischemia (SMI). However, there is a dearth of evidence on the worldwide prevalence of this very lethal and yet unrecognizable complicatio…
View article: Chemical Characterization and Antibacterial Efficacy of Essential Oils of Three Lamiaceae Species Growing in Cameroon
Chemical Characterization and Antibacterial Efficacy of Essential Oils of Three Lamiaceae Species Growing in Cameroon Open
Essential oils (EOs) have aroused attention among the naturally-occurring therapeutic compounds with anti-infective properties. This study examined the chemical composition and the antibacterial potential of EOs from three Lamiaceae specie…
View article: Recent Advances in Molecular Docking for the Research and Discovery of Potential Marine Drugs
Recent Advances in Molecular Docking for the Research and Discovery of Potential Marine Drugs Open
Marine drugs have long been used and exhibit unique advantages in clinical practices. Among the marine drugs that have been approved by the Food and Drug Administration (FDA), the protein–ligand interactions, such as cytarabine–DNA polymer…
View article: Plukenetia huayllabambana Fruits: Analysis of Bioactive Compounds, Antibacterial Activity and Relative Action Mechanisms
Plukenetia huayllabambana Fruits: Analysis of Bioactive Compounds, Antibacterial Activity and Relative Action Mechanisms Open
Plukenetia huayllabambana is an edible plant traditionally used to cure wounds and various infections. The present work assessed, for the first time, the antibacterial efficacy of solvent fractions from P. huayllabambana fruits. The crude …
View article: In Vitro Antibacterial and Antiproliferative Potential of Echinops lanceolatus Mattf. (Asteraceae) and Identification of Potential Bioactive Compounds
In Vitro Antibacterial and Antiproliferative Potential of Echinops lanceolatus Mattf. (Asteraceae) and Identification of Potential Bioactive Compounds Open
Many species belonging to the genus Echinops are widely used in traditional medicine to treat infectious diseases and cancers. The present study aimed to evaluate the antibacterial and antiproliferative properties of Echinops lanceolatus M…
View article: Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification
Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification Open
View article: A REVIEW ON TRADITIONAL USES, PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILES, SPIRITUAL AND ECONOMIC VALUES, AND TOXICITY OF DACRYODES EDULIS (G. DON) H.J. LAM.
A REVIEW ON TRADITIONAL USES, PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILES, SPIRITUAL AND ECONOMIC VALUES, AND TOXICITY OF DACRYODES EDULIS (G. DON) H.J. LAM. Open
Since ancient times, medicinal plants have played a key role in the management of some health problems and in the discovery of new drugs. For many years, Dacryodes edulis (G. Don) is reported to be used by local populations of West and Cen…
View article: Antibacterial and antibiotic-resistance modifying activity of the extracts and compounds from Nauclea pobeguinii against Gram-negative multi-drug resistant phenotypes
Antibacterial and antibiotic-resistance modifying activity of the extracts and compounds from Nauclea pobeguinii against Gram-negative multi-drug resistant phenotypes Open
View article: Antibacterial activities and structure–activity relationships of a panel of 48 compounds from Kenyan plants against multidrug resistant phenotypes
Antibacterial activities and structure–activity relationships of a panel of 48 compounds from Kenyan plants against multidrug resistant phenotypes Open
View article: Antibacterial activities of the methanol extracts and compounds from Uapaca togoensis against Gram-negative multi-drug resistant phenotypes
Antibacterial activities of the methanol extracts and compounds from Uapaca togoensis against Gram-negative multi-drug resistant phenotypes Open
Uapaca togoensis is a medicinal plant used in sub-Saharan Africa to treat various ailments including bacterial infections. In the present study, the methanol extracts from the fruits (UTF), bark (UTB) and leaves (UTL) of this plant as well…
View article: Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria
Antibacterial activities of Fagara macrophylla, Canarium schweinfurthii, Myrianthus arboreus, Dischistocalyx grandifolius and Tragia benthamii against multi-drug resistant Gram-negative bacteria Open
View article: Cytotoxicity of selected Cameroonian medicinal plants and Nauclea pobeguinii towards multi-factorial drug-resistant cancer cells
Cytotoxicity of selected Cameroonian medicinal plants and Nauclea pobeguinii towards multi-factorial drug-resistant cancer cells Open