Armelle Yart
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View article: Brown adipose tissue activity impacts systemic lactate clearance in male mice
Brown adipose tissue activity impacts systemic lactate clearance in male mice Open
Non‐shivering thermogenesis in brown adipose tissue (BAT) is linked to metabolic health. Yet, how its activity states impact on systemic metabolism and in particular on lactate, a highly abundant metabolite increasingly recognized as a cri…
View article: Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age
Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age Open
Aging leads to a decline in physiological reserves, an increase in age‐related diseases, reduced functional ability and a shortened healthspan. While molecular markers of chronological aging exist, their link to general health and intrinsi…
View article: EndoCompass project: research roadmap for growth disorders
EndoCompass project: research roadmap for growth disorders Open
Background Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impa…
View article: Novel therapeutic perspectives in Noonan syndrome and RASopathies
Novel therapeutic perspectives in Noonan syndrome and RASopathies Open
Noonan syndrome belongs to the family of RASopathies, a group of multiple congenital anomaly disorders caused by pathogenic variants in genes encoding components or regulators of the RAS/mitogen-activated protein kinase (MAPK) signalling p…
View article: The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance?
The Tyrosine Phosphatase SHP2: A New Target for Insulin Resistance? Open
The SH2 containing protein tyrosine phosphatase 2(SHP2) plays essential roles in fundamental signaling pathways, conferring on it versatile physiological functions during development and in homeostasis maintenance, and leading to major pat…
View article: Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor
Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor Open
Dysregulations of lipid metabolism in the liver may trigger steatosis progression, leading to potentially severe clinical consequences such as nonalcoholic fatty liver diseases (NAFLDs). Molecular mechanisms underlying liver lipogenesis ar…
View article: Low bone mass in Noonan syndrome children correlates with decreased muscle mass and low IGF-1 levels
Low bone mass in Noonan syndrome children correlates with decreased muscle mass and low IGF-1 levels Open
View article: Noonan syndrome males display Sertoli cell-specific primary testicular insufficiency
Noonan syndrome males display Sertoli cell-specific primary testicular insufficiency Open
Context Abnormalities in the hypothalamo–pituitary–gonadal axis have long been reported in Noonan syndrome (NS) males with only few data available in prepubertal children. Objective The aim of this study was to describe the gonadal functio…