Armetta Hill
YOU?
Author Swipe
View article: Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts
Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts Open
Disruptions in the gut epithelial barrier can lead to the development of chronic indications such as inflammatory bowel disease (IBD). Historically, barrier function has been assessed in cancer cell lines, which do not contain all human in…
View article: Development of a high-throughput barrier function assay using primary human gut organoids
Development of a high-throughput barrier function assay using primary human gut organoids Open
Disruptions in the gut epithelial barrier can lead to the development of chronic indications such as inflammatory bowel disease (IBD). Historically, barrier function has been assessed in cancer cell lines, which do not contain all human in…
View article: Discovery of <b>MK-4688</b> : an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction
Discovery of <b>MK-4688</b> : an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction Open
Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant eff…
View article: Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators Open
The approvals of idelalisib and duvelisib have validated PI3Kδ inhibitors for the treatment for hematological malignancies driven by the PI3K/AKT pathway. Our program led to the identification of structurally distinct heterocycloalkyl puri…
Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors Open
The 3,3-disubstituted oxindole moiety is a versatile and rigid three-dimensionally shaped scaffold. When engineered with a purine hinge-binding core, exceptionally selective PI3Kδ kinase inhibitors were discovered by exploiting small diffe…