Armin Blesch
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View article: ID3-depleted human induced pluripotent stem cell–derived neural stem/progenitor cells promote neurorepair
ID3-depleted human induced pluripotent stem cell–derived neural stem/progenitor cells promote neurorepair Open
Human induced pluripotent stem cell–derived neural stem/progenitor cells are used in cell-replacement and regenerative therapeutic strategies after traumatic central nervous system injury. Traumatic injury alters the host microenvironment,…
View article: Lessons Learned and Recommendations from a SCOPE Spinal Cord Injury Neurorestorative Clinical Trials Update
Lessons Learned and Recommendations from a SCOPE Spinal Cord Injury Neurorestorative Clinical Trials Update Open
The Spinal Cord Outcomes Partnership Endeavors presented a clinical trials update (CTU) in collaboration with the International Spinal Research Trust as a precourse to their annual meeting. Selected trials adhered to a priori consideration…
View article: Alginate hydrogel cross-linked by Ca2+ to promote spinal cord neural stem/progenitor cell differentiation and functional recovery after a spinal cord injuryhh
Alginate hydrogel cross-linked by Ca2+ to promote spinal cord neural stem/progenitor cell differentiation and functional recovery after a spinal cord injuryhh Open
Alginate capillary hydrogels seeded with differentiated cells can fill the lesion cavity and promote axonal regeneration after grafting into the injured spinal cord. Neural stem/progenitor cells (NSPCs) can potentially repair the spinal co…
View article: Neural Stem Cells: Promoting Axonal Regeneration and Spinal Cord Connectivity
Neural Stem Cells: Promoting Axonal Regeneration and Spinal Cord Connectivity Open
Spinal cord injury (SCI) leads to irreversible functional impairment caused by neuronal loss and the disruption of neuronal connections across the injury site. While several experimental strategies have been used to minimize tissue damage …
View article: Sensorimotor Activity Partially Ameliorates Pain and Reduces Nociceptive Fiber Density in the Chronically Injured Spinal Cord
Sensorimotor Activity Partially Ameliorates Pain and Reduces Nociceptive Fiber Density in the Chronically Injured Spinal Cord Open
A large proportion of patients suffering from spinal cord injury (SCI) develop chronic central neuropathic pain. Previously, we and others have shown that sensorimotor training early after SCI can prevent the development of mechanical allo…
View article: Targeted tissue engineering: hydrogels with linear capillary channels for axonal regeneration after spinal cord injury
Targeted tissue engineering: hydrogels with linear capillary channels for axonal regeneration after spinal cord injury Open
Spinal cord injury (SCI) frequently results in the permanent loss of function below the level of injury due to the failure of axonal regeneration in the adult mammalian central nervous system (CNS). The limited intrinsic growth capacity of…
View article: Targeted tissue engineering: hydrogels with linear capillary channels for axonal regeneration after spinal cord injury
Targeted tissue engineering: hydrogels with linear capillary channels for axonal regeneration after spinal cord injury Open
Spinal cord injury (SCI) frequently results in the permanent loss of function below the level of injury due to the failure of axonal regeneration in the adult mammalian central nervous system (CNS). The limited intrinsic growth capacity of…
View article: Limited Functional Effects of Subacute Syngeneic Bone Marrow Stromal Cell Transplantation after Rat Spinal Cord Contusion Injury
Limited Functional Effects of Subacute Syngeneic Bone Marrow Stromal Cell Transplantation after Rat Spinal Cord Contusion Injury Open
Cell transplantation might be one means to improve motor, sensory, or autonomic recovery after traumatic spinal cord injury (SCI). Among the different cell types evaluated to date, bone marrow stromal cells (BMSCs) have received considerab…
View article: Gene Therapy for Spinal Cord Injury
Gene Therapy for Spinal Cord Injury Open
New insights into the pathophysiological mechanisms that contribute to the limited functional recovery after spinal cord injury (SCI) have led to the development of several novel experimental approaches. Gene therapy is one means to identi…
View article: Axonal Amphoterin mRNA Is Regulated by Translational Control and Enhances Axon Outgrowth
Axonal Amphoterin mRNA Is Regulated by Translational Control and Enhances Axon Outgrowth Open
High mobility group (HMG) proteins concentrate in the nucleus, interacting with chromatin. Amphoterin is an HMG protein (HMGB1) that has been shown to have extranuclear functions and can be secreted from some cell types. Exogenous amphoter…
View article: Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury Open
Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms to promote axon extension and early suppression of scar formation. Microtubule stabilization could provide, i…