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View article: Explainable AI in nuclear medicine
Explainable AI in nuclear medicine Open
We conclude that explanations are likely required when a black box AI tool undertakes tasks that users cannot perform or validate themselves. If the user can verify outputs manually, documented reliability and accuracy may suffice, but exp…
View article: Pleural tail sign in computed tomography-guided lung biopsy: an imaging predictor of severe pneumothorax requiring chest tube placement
Pleural tail sign in computed tomography-guided lung biopsy: an imaging predictor of severe pneumothorax requiring chest tube placement Open
The identification of a triangular PTS on pre-interventional CT imaging may help to stratify patients at higher risk of severe pneumothorax following CT-guided lung biopsy. This could enable more informed procedural planning, potentially l…
View article: The role of interventional pulmonology in management of pulmonary nodules during lung cancer screening
The role of interventional pulmonology in management of pulmonary nodules during lung cancer screening Open
The implementation of lung cancer screening with low-dose computed tomography has significantly increased the detection of pulmonary nodules, most of which are peripherally located and difficult to access. Effectively addressing these find…
View article: Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative
Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative Open
We present a large whole-body and total-body curated dataset of dual-modality 2-deoxy-2-[18F]fluoro-D-glucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) studies, consisting of 1,597 PET/CT images and the corresponding …
View article: Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative
Sharing a whole-/total-body [18F]FDG-PET/CT dataset with CT-derived segmentations: an ENHANCE.PET initiative Open
We present a large whole-body and total-body curated dataset of dual-modality 2-deoxy-2-[18F]fluoro-D-glucose (FDG)-Positron Emission Tomography/Computed Tomography (PET/CT) studies, consisting of 1,597 PET/CT images and the corresponding …
View article: AGREE-II appraisal of lung cancer management clinical practice guidelines by the OPTIMA consortium
AGREE-II appraisal of lung cancer management clinical practice guidelines by the OPTIMA consortium Open
We identified and critically appraised 21 European lung cancer guidelines published between 2009 and 2025. Key recommendations for improvement include inclusion of diverse specialities and patient representatives in guideline development a…
View article: Corrigendum: TP53 co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside KRAS, STK11 and KEAP1 mutations
Corrigendum: TP53 co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside KRAS, STK11 and KEAP1 mutations Open
[This corrects the article DOI: 10.3389/fonc.2024.1357583.].
View article: Detection of cancer‐associated cachexia in lung cancer patients using whole‐body [<sup>18</sup>F]FDG‐PET/CT imaging: A multi‐centre study
Detection of cancer‐associated cachexia in lung cancer patients using whole‐body [<sup>18</sup>F]FDG‐PET/CT imaging: A multi‐centre study Open
Background Cancer‐associated cachexia (CAC) is a metabolic syndrome contributing to therapy resistance and mortality in lung cancer patients (LCP). CAC is typically defined using clinical non‐imaging criteria. Given the metabolic underpinn…
View article: Respiratory Syncytial Virus in Adult Patients at a Tertiary Care Hospital in Germany: Clinical Features and Molecular Epidemiology of the Fusion Protein in the Severe Respiratory Season of 2022/2023
Respiratory Syncytial Virus in Adult Patients at a Tertiary Care Hospital in Germany: Clinical Features and Molecular Epidemiology of the Fusion Protein in the Severe Respiratory Season of 2022/2023 Open
Following an interseasonal rise in mainly pediatric respiratory syncytial virus (RSV) cases in Germany in 2021, an exceptionally high number of adult cases was observed in the subsequent respiratory season of 2022/2023. The aim of this stu…
View article: Lung cancer screening: where do we stand?
Lung cancer screening: where do we stand? Open
Lung cancer screening (LCS) programmes have emerged over recent years around the world. LCS programmes present differences in delivery, inclusion criteria and resource allocation. On a national scale, only a few LCS programmes have been fu…
View article: Resistance to KRAS inhibition in advanced non-small cell lung cancer
Resistance to KRAS inhibition in advanced non-small cell lung cancer Open
Lung cancer remains the leading cause of cancer death globally. More than 50% of new cases are diagnosed in an advanced or metastatic stage, thus contributing to the poor survival of such patients. Mutations in the KRAS (Kirsten rat sarcom…
View article: How will lung cancer screening and lung nodule management change the diagnostic and surgical lung cancer landscape?
How will lung cancer screening and lung nodule management change the diagnostic and surgical lung cancer landscape? Open
Introduction: Implementation of lung cancer screening, with its subsequent findings, is anticipated to change the current diagnostic and surgical lung cancer landscape. This review aimed to identify and present the most updated expert opin…
View article: TP53 co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside KRAS, STK11 and KEAP1 mutations
TP53 co-mutations in advanced lung adenocarcinoma: comparative bioinformatic analyses suggest ambivalent character on overall survival alongside KRAS, STK11 and KEAP1 mutations Open
Background Recently, we could show that the co-mutations of KRAS + KEAP1 , STK11 + KEAP1 and KRAS + STK11 + KEAP1 lead to a significantly shorter median overall survival (mOS) in patients with lung cancer across treatments by analyzing mul…
View article: “Metabolic fingerprints” of cachexia in lung cancer patients
“Metabolic fingerprints” of cachexia in lung cancer patients Open
Our European consortium was awarded research funding from the EraPerMED consortium [14] (LuCaPET project, grant number ERAPerMed_324, “Clinical decision support for predicting cachexia in cancer patients using hybrid PET/CT imaging”) to st…
View article: New developments in the imaging of lung cancer
New developments in the imaging of lung cancer Open
Radiological and nuclear medicine methods play a fundamental role in the diagnosis and staging of patients with lung cancer. Imaging is essential in the detection, characterisation, staging and follow-up of lung cancer. Due to the increasi…
View article: Outcomes of oncological intended thoracic surgery after lung transplantation
Outcomes of oncological intended thoracic surgery after lung transplantation Open
Incidence of lung cancer is increased after LT. Follow-up care allows early diagnosis with a comparably high share of operable tumor stage. Cancer as well as postoperative complications were more likely after single lung transplantation (S…
View article: Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor
Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor Open
Objective Acyl-CoA-binding protein (ACBP)/diazepam-binding inhibitor has lately been described as an endocrine factor affecting food intake and lipid metabolism. ACBP is dysregulated in catabolic/malnutrition states like sepsis or systemic…
View article: In-Depth Analysis of the Re-Emergence of Respiratory Syncytial Virus at a Tertiary Care Hospital in Germany in the Summer of 2021 after the Alleviation of Non-Pharmaceutical Interventions Due to the SARS-CoV-2 Pandemic
In-Depth Analysis of the Re-Emergence of Respiratory Syncytial Virus at a Tertiary Care Hospital in Germany in the Summer of 2021 after the Alleviation of Non-Pharmaceutical Interventions Due to the SARS-CoV-2 Pandemic Open
Following the extensive non-pharmaceutical interventions (NPIs) and behavioral changes in the wake of the SARS-CoV-2 pandemic, an interseasonal rise in respiratory syncytial virus (RSV) cases was observed in Germany in 2021. The aim of thi…
View article: CT texture analysis and node-RADS CT score of mediastinal lymph nodes - diagnostic performance in lung cancer patients
CT texture analysis and node-RADS CT score of mediastinal lymph nodes - diagnostic performance in lung cancer patients Open
Background Texture analysis derived from computed tomography (CT) can provide clinically relevant imaging biomarkers. Node-RADS is a recently proposed classification to categorize lymph nodes in radiological images. The present study sough…
View article: CT Texture Analysis of Pulmonary Neuroendocrine Tumors—Associations with Tumor Grading and Proliferation
CT Texture Analysis of Pulmonary Neuroendocrine Tumors—Associations with Tumor Grading and Proliferation Open
Texture analysis derived from computed tomography (CT) might be able to provide clinically relevant imaging biomarkers and might be associated with histopathological features in tumors. The present study sought to elucidate the possible as…
View article: Associations of aspirin, statins and metformin with lung cancer risk and related mortality
Associations of aspirin, statins and metformin with lung cancer risk and related mortality Open
Given the poor survival of lung cancer patients and the promising observations herein, future studies (RCTs) should further investigate both time- and dose-dependent effects of combination therapies across all categories of prevention of l…
View article: Multidisciplinary care models for patients with lung cancer
Multidisciplinary care models for patients with lung cancer Open
Multidisciplinary care is the cornerstone of lung cancer treatment in the developed world, even though there is a relative lack of consistent evidence that this care model improves outcomes. In this review, we present the available literat…
View article: Lung cancer incidence and mortality with extended follow-up in the National Lung Screening Trial
Lung cancer incidence and mortality with extended follow-up in the National Lung Screening Trial Open
The extended follow-up of the NLST represents a timely and important update to the NLST data, alongside full results of the NELSON and the LUSI trials, as Europe begins to set out a vision for lung cancer screening. http://bit.ly/2MYXedI.
View article: Oxygen devices and delivery systems
Oxygen devices and delivery systems Open
Oxygen use has extended from inpatient to outpatient settings for patients with chronic pulmonary diseases and complications of hypoxaemia. This article presents an overview of oxygen devices (oxygen concentrators, compressed gas cylinders…
View article: No erythropoietin-induced growth is observed in non-small cell lung cancer cells
No erythropoietin-induced growth is observed in non-small cell lung cancer cells Open
Lung cancer patients have the highest incidence of anemia among patients with solid tumors. The use of recombinant human erythropoietin (Epo) has consistently been shown to reduce the need for blood transfusions and to increase hemoglobin …