Arnau Hervera
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View article: Multiple sclerosis: molecular pathogenesis and therapeutic intervention
Multiple sclerosis: molecular pathogenesis and therapeutic intervention Open
Multiple sclerosis is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, axonal loss, and neuroinflammation, culminating in progressive neurological disability. Despite significant advances in …
View article: Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence
Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence Open
The onset of multiple sclerosis (MS) in older individuals correlates with a higher risk of developing primary progressive MS, faster progression to secondary progressive MS, and increased disability accumulation. This phenomenon can be rel…
View article: Neuronal chemokines: new insights into neuronal communication after injury
Neuronal chemokines: new insights into neuronal communication after injury Open
Classically, chemokines were described as small proteins driving leukocyte migration. Nonetheless, more and more studies are showing the great variety of cell functions and tissues in which they participate, including neural cells. During …
View article: Editorial: Biochemical and genetic tools to investigate the underlying mechanisms and treatment of sensorimotor pathologies
Editorial: Biochemical and genetic tools to investigate the underlying mechanisms and treatment of sensorimotor pathologies Open
EDITORIAL article Front. Mol. Neurosci., 10 October 2022Sec. Molecular Signalling and Pathways Volume 15 - 2022 | https://doi.org/10.3389/fnmol.2022.1041458
View article: Genetic control of neuronal activity enhances axonal growth only on permissive substrates
Genetic control of neuronal activity enhances axonal growth only on permissive substrates Open
Background Neural tissue has limited regenerative ability. To cope with that, in recent years a diverse set of novel tools has been used to tailor neurostimulation therapies and promote functional regeneration after axonal injuries. Method…
View article: Nociception-Dependent CCL21 Induces Dorsal Root Ganglia Axonal Growth via CCR7-ERK Activation
Nociception-Dependent CCL21 Induces Dorsal Root Ganglia Axonal Growth via CCR7-ERK Activation Open
While chemokines were originally described for their ability to induce cell migration, many studies show how these proteins also take part in many other cell functions, acting as adaptable messengers in the communication between a diversit…
View article: Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development Open
Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial …
View article: Nociception-dependent CCL21 induce dorsal root ganglia axonal growth via CCR7-ERK activation
Nociception-dependent CCL21 induce dorsal root ganglia axonal growth via CCR7-ERK activation Open
While chemokines were originally described for their ability to induce cell migration, many studies show how chemokines also take part in a variety of other cell functions, acting as adaptable messengers in the communication between a dive…
View article: Genetic control of neuronal activity enhances axonal growth only on permissive substrates
Genetic control of neuronal activity enhances axonal growth only on permissive substrates Open
Neural tissue has limited regenerative ability, to cope with that, in the recent years a diverse set of novel tools have been used to tailor neurostimulation therapies and promote functional regeneration after axonal injuries. In this repo…
View article: Additional file 10 of Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability
Additional file 10 of Analysis of co-isogenic prion protein deficient mice reveals behavioral deficits, learning impairment, and enhanced hippocampal excitability Open
Additional file 10. Excel file 1. File providing individual data values for all figures from the manuscript.
View article: Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora
Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora Open
Lafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates—the so-called Lafora Bodies (LBs)—in several organs. The accumulation of LBs in the brain underlies the neurological…
View article: Involvement of mechanical cues in the migration of Cajal-Retzius cells in the marginal zone during neocortical development
Involvement of mechanical cues in the migration of Cajal-Retzius cells in the marginal zone during neocortical development Open
Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial …
View article: Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism
Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism Open
Peripheral inputs to the brain continuously shape its function and adjust non-emotional memory, but the mechanisms involved are not fully understood. Cannabinoid type-1 receptors (CB1Rs), widely distributed in the organism, are well recogn…
View article: Lack of p62 impairs glycogen aggregation and exacerbates pathology in a mouse model of myoclonic epilepsy of Lafora
Lack of p62 impairs glycogen aggregation and exacerbates pathology in a mouse model of myoclonic epilepsy of Lafora Open
Background Lafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates—the so-called Lafora Bodies (LBs)—in several organs. The accumulation of LBs in the brain underlies the n…
View article: Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease
Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease Open
The hallmark of Lafora disease, a fatal neurodegenerative disorder, is the accumulation of intracellular glycogen aggregates called Lafora bodies. Until recently, it was widely believed that brain Lafora bodies were present exclusively in …
View article: Behavioral deficits, learning impairment, and enhanced hippocampal excitability in co-isogenic <i>Prnp<sup>ZH3/ZH3</sup></i> mice
Behavioral deficits, learning impairment, and enhanced hippocampal excitability in co-isogenic <i>Prnp<sup>ZH3/ZH3</sup></i> mice Open
Background The cellular prion protein (PrP C ) has been associated with numerous cellular processes, such as cell differentiation and neurotransmission. Moreover, it was recently demonstrated that some functions were misattributed to PrP C…
View article: Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models
Cyclin-dependent–like kinase 5 is required for pain signaling in human sensory neurons and mouse models Open
CDKL5 controls nociception in human neurons and murine models of CDKL5 deficiency disorder via CaMKII-dependent mechanisms.
View article: Lack of astrocytic glycogen alters synaptic plasticity but not seizure susceptibility
Lack of astrocytic glycogen alters synaptic plasticity but not seizure susceptibility Open
Brain glycogen is mainly stored in astrocytes. However, recent studies both in vitro and in vivo indicate that glycogen also plays important roles in neurons. By conditional deletion of glycogen synthase (GYS1), we previously developed a m…
View article: Neuromuscular Activity Induces Paracrine Signaling and Triggers Axonal Regrowth after Injury in Microfluidic Lab-On-Chip Devices
Neuromuscular Activity Induces Paracrine Signaling and Triggers Axonal Regrowth after Injury in Microfluidic Lab-On-Chip Devices Open
Peripheral nerve injuries, including motor neuron axonal injury, often lead to functional impairments. Current therapies are mostly limited to surgical intervention after lesion, yet these interventions have limited success in restoring fu…
View article: Cyclin-dependent-like kinase 5 is required for pain signalling in both human neurons and mouse models
Cyclin-dependent-like kinase 5 is required for pain signalling in both human neurons and mouse models Open
Cyclin-dependent-like kinase 5 ( Cdkl5) gene mutations lead to an X-linked disorder that is characterized by infantile epileptic encephalopathy, developmental delay and hypotonia. However, we found that a substantial percentage of these pa…
View article: Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models
Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models Open
Environmental enrichment induces activity-dependent histone acetylation via a druggable mechanism to promote recovery after spinal cord injury.
View article: Challenges and Future Prospects on 3D in-vitro Modeling of the Neuromuscular Circuit
Challenges and Future Prospects on 3D in-vitro Modeling of the Neuromuscular Circuit Open
Movement of skeletal-muscle fibers is generated by the coordinated action of several cells taking part within the locomotion circuit (motoneurons, sensory-neurons, Schwann cells, astrocytes, microglia, and muscle-cells). Failures in any pa…
View article: PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure
PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure Open
The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sen…