Arnaud Hecker
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View article: Biochemical and Structural Characterization of Chi-Class Glutathione Transferases: A Snapshot on the Glutathione Transferase Encoded by sll0067 Gene in the Cyanobacterium Synechocystis sp. Strain PCC 6803
Biochemical and Structural Characterization of Chi-Class Glutathione Transferases: A Snapshot on the Glutathione Transferase Encoded by sll0067 Gene in the Cyanobacterium Synechocystis sp. Strain PCC 6803 Open
Glutathione transferases (GSTs) constitute a widespread superfamily of enzymes notably involved in detoxification processes and/or in specialized metabolism. In the cyanobacterium Synechocsytis sp. PCC 6803, SynGSTC1, a chi-class GST (GSTC…
View article: Biochemical and Structural Insights on the Poplar Tau Glutathione Transferase GSTU19 and 20 Paralogs Binding Flavonoids
Biochemical and Structural Insights on the Poplar Tau Glutathione Transferase GSTU19 and 20 Paralogs Binding Flavonoids Open
Glutathione transferases (GSTs) constitute a widespread superfamily of enzymes notably involved in xenobiotic detoxification and/or in specialized metabolism. Populus trichocarpa genome (V4.1 assembly, Phytozome 13) consists of 74 genes co…
View article: Expression Patterns of Drosophila Melanogaster Glutathione Transferases
Expression Patterns of Drosophila Melanogaster Glutathione Transferases Open
Glutathione transferases (GSTs) are ubiquitous enzymes that catalyze the conjugation of glutathione to various molecules. Among the 42 GSTs identified in Drosophila melanogaster, Delta and Epsilon are the largest classes, with 25 members. …
View article: Coumarin accumulation and trafficking in <i>Arabidopsis thaliana</i>: a complex and dynamic process
Coumarin accumulation and trafficking in <i>Arabidopsis thaliana</i>: a complex and dynamic process Open
Summary Iron (Fe) is a major micronutrient and is required for plant growth and development. Nongrass species have evolved a reduction‐based strategy to solubilize and take up Fe. The secretion of Fe‐mobilizing coumarins (e.g. fraxetin, es…
View article: Methylglyoxal Detoxification Revisited: Role of Glutathione Transferase in Model Cyanobacterium <i>Synechocystis</i> sp. Strain PCC 6803
Methylglyoxal Detoxification Revisited: Role of Glutathione Transferase in Model Cyanobacterium <i>Synechocystis</i> sp. Strain PCC 6803 Open
In most organisms, methylglyoxal (MG), a toxic metabolite by-product that causes diabetes in humans, is predominantly detoxified by the glyoxalase enzymes. This process begins with the so-called “spontaneous” conjugation of MG with the cyt…
View article: Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants?
Is there a role for tau glutathione transferases in tetrapyrrole metabolism and retrograde signalling in plants? Open
In plants, tetrapyrrole biosynthesis occurs in chloroplasts, the reactions being catalysed by stromal and membrane-bound enzymes. The tetrapyrrole moiety is a backbone for chlorophylls and cofactors such as sirohaems, haems and phytochromo…
View article: Structural genomics applied to the rust fungus Melampsora larici-populina reveals two candidate effector proteins adopting cystine knot and NTF2-like protein folds
Structural genomics applied to the rust fungus Melampsora larici-populina reveals two candidate effector proteins adopting cystine knot and NTF2-like protein folds Open
Rust fungi are plant pathogens that secrete an arsenal of effector proteins interfering with plant functions and promoting parasitic infection. Effectors are often species-specific, evolve rapidly, and display low sequence similarities wit…
View article: Editorial: Plant Glutathione Transferases: Diverse, Multi-Tasking Enzymes With Yet-to-Be Discovered Functions
Editorial: Plant Glutathione Transferases: Diverse, Multi-Tasking Enzymes With Yet-to-Be Discovered Functions Open
International audience
View article: Structural genomic applied on the rust fungus <i>Melampsora larici-populina</i> reveals two candidate effector proteins adopting cystine-knot and nuclear transport factor 2-like protein folds
Structural genomic applied on the rust fungus <i>Melampsora larici-populina</i> reveals two candidate effector proteins adopting cystine-knot and nuclear transport factor 2-like protein folds Open
Rust fungi are plant pathogens that secrete an arsenal of effector proteins interfering with plant functions and promoting parasitic infection. Effectors are often species-specific, evolve rapidly, and display low sequence similarities wit…
View article: <i>Laccaria bicolor</i> MiSSP8 is a small‐secreted protein decisive for the establishment of the ectomycorrhizal symbiosis
<i>Laccaria bicolor</i> MiSSP8 is a small‐secreted protein decisive for the establishment of the ectomycorrhizal symbiosis Open
Summary The ectomycorrhizal symbiosis is a predominant tree–microbe interaction in forest ecosystems sustaining tree growth and health. Its establishment and functioning implies a long‐term and intimate relationship between the soil‐borne …
View article: Functional, Structural and Biochemical Features of Plant Serinyl-Glutathione Transferases
Functional, Structural and Biochemical Features of Plant Serinyl-Glutathione Transferases Open
Glutathione transferases (GSTs) belong to a ubiquitous multigenic family of enzymes involved in diverse biological processes including xenobiotic detoxification and secondary metabolism. A canonical GST is formed by two domains, the N-term…
View article: Advances in understanding obligate biotrophy in rust fungi
Advances in understanding obligate biotrophy in rust fungi Open
Summary Rust fungi (Pucciniales) are the largest group of plant pathogens and represent one of the most devastating threats to agricultural crops worldwide. Despite the economic importance of these highly specialized pathogens, many aspect…
View article: The Rust Fungus <i>Melampsora larici-populina</i> Expresses a Conserved Genetic Program and Distinct Sets of Secreted Protein Genes During Infection of Its Two Host Plants, Larch and Poplar
The Rust Fungus <i>Melampsora larici-populina</i> Expresses a Conserved Genetic Program and Distinct Sets of Secreted Protein Genes During Infection of Its Two Host Plants, Larch and Poplar Open
Mechanisms required for broad-spectrum or specific host colonization of plant parasites are poorly understood. As a perfect illustration, heteroecious rust fungi require two alternate host plants to complete their life cycles. Melampsora l…
View article: The rust fungus <i>Melampsora larici-populina</i> expresses a conserved genetic program and distinct sets of secreted protein genes during infection of its two host plants, larch and poplar
The rust fungus <i>Melampsora larici-populina</i> expresses a conserved genetic program and distinct sets of secreted protein genes during infection of its two host plants, larch and poplar Open
Summary Mechanims required for broad spectrum or specific host colonization of plant parasites are poorly understood. As a perfect illustration, heteroecious rust fungi require two alternate host plants to complete their life cycle. Melamp…
View article: <i>Laccaria bicolor</i> MiSSP8 is a small-secreted protein decisive for the establishment of the ectomycorrhizal symbiosis
<i>Laccaria bicolor</i> MiSSP8 is a small-secreted protein decisive for the establishment of the ectomycorrhizal symbiosis Open
The ectomycorrhizal symbiosis is a predominant tree-microbe interaction in forest ecosystems sustaining tree growth and health. Its establishment and functioning implies a long-term and intimate relationship between the soil-borne fungi an…
View article: Structural plasticity among glutathione transferase Phi members: natural combination of catalytic residues confers dual biochemical activities
Structural plasticity among glutathione transferase Phi members: natural combination of catalytic residues confers dual biochemical activities Open
The glutathione transferase (GST) gene family is divided into 14 classes in photosynthetic organisms. Among them, the Phi class (GSTF) is composed of a large number of genes that are often induced in response to environmental constraints d…
View article: Covalent and Non-Covalent Associations Mediate MED28 Homo- Oligomerization
Covalent and Non-Covalent Associations Mediate MED28 Homo- Oligomerization Open
The Mediator is a multi-protein complex that plays a key role in modulating gene expression. Our previous studies suggested that the MED10a, MED28, MED32 complex subunits could be subject to redox regulation. In this study we tested the ca…
View article: Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones
Crystal Structure of Saccharomyces cerevisiae ECM4, a Xi-Class Glutathione Transferase that Reacts with Glutathionyl-(hydro)quinones Open
Glutathionyl-hydroquinone reductases (GHRs) belong to the recently characterized Xi-class of glutathione transferases (GSTXs) according to unique structural properties and are present in all but animal kingdoms. The GHR ScECM4 from the yea…
View article: Structural view of fungal glutathionyl-hydroquinone reductases
Structural view of fungal glutathionyl-hydroquinone reductases Open
International audience
View article: Chloroplast FBPase and SBPase are thioredoxin-linked enzymes with similar architecture but different evolutionary histories
Chloroplast FBPase and SBPase are thioredoxin-linked enzymes with similar architecture but different evolutionary histories Open
Significance We demonstrate that, although the two phosphatases of the Calvin–Benson cycle of photosynthesis [sedoheptulose-1,7-bisphosphatase (SBPase) and fructose-1,6-bisphosphatase (FBPase)] share extensive structural homology, their re…
View article: The Poplar Rust-Induced Secreted Protein (RISP) Inhibits the Growth of the Leaf Rust Pathogen Melampsora larici-populina and Triggers Cell Culture Alkalinisation
The Poplar Rust-Induced Secreted Protein (RISP) Inhibits the Growth of the Leaf Rust Pathogen Melampsora larici-populina and Triggers Cell Culture Alkalinisation Open
Plant cells secrete a wide range of proteins in extracellular spaces in response to pathogen attack. The poplar rust-induced secreted protein (RISP) is a small cationic protein of unknown function that was identified as the most induced ge…
View article: Effector-Mining in the Poplar Rust Fungus Melampsora larici-populina Secretome
Effector-Mining in the Poplar Rust Fungus Melampsora larici-populina Secretome Open
The poplar leaf rust fungus, Melampsora larici-populina has been established as a tree-microbe interaction model. Understanding the molecular mechanisms controlling infection by pathogens appears essential for durable management of tree pl…
View article: The GSTome Reflects the Chemical Environment of White-Rot Fungi
The GSTome Reflects the Chemical Environment of White-Rot Fungi Open
White-rot fungi possess the unique ability to degrade and mineralize all the different components of wood. In other respects, wood durability, among other factors, is due to the presence of extractives that are potential antimicrobial mole…