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View article: Uncovering an antifibrotic <i>Prrx1</i>-lineage mesenchymal cell subpopulation in fibrotic lungs
Uncovering an antifibrotic <i>Prrx1</i>-lineage mesenchymal cell subpopulation in fibrotic lungs Open
Idiopathic pulmonary fibrosis (IPF) is a rare and fatal lung disease caused by progressive damage to alveolar epithelial cells, leading to abnormal activation of mesenchymal cells. The PRRX1 transcription factor (TF) has been found to be r…
View article: ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly
ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly Open
Early career members of Assembly 3 (Basic and Translational Sciences) of the European Respiratory Society (ERS) summarise the key messages discussed during six selected sessions that took place at the ERS International Congress 2023 in Mil…
View article: Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis
Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis Open
Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF). Targeting cells driving matrix remodeling could be a promising avenue for IPF treatment. Analysis of transcriptomic database identified the mesenchymal transcri…
View article: Author response: Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis
Author response: Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis Open
View article: ERS International Congress 2022: highlights from the Basic and Translational Science Assembly
ERS International Congress 2022: highlights from the Basic and Translational Science Assembly Open
In this review, the Basic and Translational Science Assembly of the European Respiratory Society provides an overview of the 2022 International Congress highlights. We discuss the consequences of respiratory events from birth until old age…
View article: COVID-19 acute respiratory distress syndrome promotes a specific alternative macrophage polarization
COVID-19 acute respiratory distress syndrome promotes a specific alternative macrophage polarization Open
View article: New insights into methylome alterations and consequences during myofibroblastic differentiation in pulmonary fibrosis
New insights into methylome alterations and consequences during myofibroblastic differentiation in pulmonary fibrosis Open
Fibroblasts within the stroma play a crucial role in tissue architecture homeostasis. These mesenchymal cells are at the front line after tissue injury to support epithelial repair through their differentiation into "physiological" myofibr…
View article: Aberrant Multiciliogenesis in Pulmonary Fibrosis: Bystander or Driver of Disease Progression?
Aberrant Multiciliogenesis in Pulmonary Fibrosis: Bystander or Driver of Disease Progression? Open
View article: Lung Fibroblasts from Idiopathic Pulmonary Fibrosis Patients Harbor Short and Unstable Telomeres Leading to Chromosomal Instability
Lung Fibroblasts from Idiopathic Pulmonary Fibrosis Patients Harbor Short and Unstable Telomeres Leading to Chromosomal Instability Open
Idiopathic pulmonary fibrosis (IPF) is associated with several hallmarks of aging including telomere shortening, which can result from germline mutations in telomere related genes (TRGs). Here, we assessed the length and stability of telom…
View article: Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia
Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia Open
Increased blood fibrocytes are associated with a poor prognosis in fibrotic lung diseases. We aimed to determine whether the percentage of circulating fibrocytes could be predictive of severity and prognosis during coronavirus disease 2019…
View article: Involvement of FGFR4 in Pulmonary Fibrosis Pathophysiology
Involvement of FGFR4 in Pulmonary Fibrosis Pathophysiology Open
Rationale :Idiopathic Pulmonary Fibrosis (IPF) is characterized by the reactivation of developmental pathways, such as Fibroblast Growth Factors (FGF).FGFR4, a FGF receptor which is not targeted by nintedanib, has been suggested to modulat…
View article: Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis
Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in Idiopathic Pulmonary Fibrosis Open
Matrix remodeling is a salient feature of idiopathic pulmonary fibrosis (IPF). Targeting cells driving matrix remodeling could be a promising avenue for IPF treatment. Analysis of transcriptomic database identified the mesenchymal transcri…
View article: Basophils and IgE contribute to mixed connective tissue disease development
Basophils and IgE contribute to mixed connective tissue disease development Open
View article: Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis
Chaotic activation of developmental signalling pathways drives idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is characterised by an important remodelling of lung parenchyma. Current evidence indicates that the disease is triggered by alveolar epithelium activation following chronic lung injury, resulting in alv…
View article: Fibroblast Growth Facor 19, a Downregulated Factor in Idiopathic Pulmonary Fibrosis, Inhibits Mice Lung Fibrosis
Fibroblast Growth Facor 19, a Downregulated Factor in Idiopathic Pulmonary Fibrosis, Inhibits Mice Lung Fibrosis Open
View article: TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signalling
TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signalling Open
Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterised by myofibroblast proliferation and abnormal extracellular matrix accumulation in the lungs. Transforming growth factor (TGF)-β1 initiates key profibrotic…
View article: Regulator of telomere length 1 (<i>RTEL1</i>) mutations are associated with heterogeneous pulmonary and extra-pulmonary phenotypes
Regulator of telomere length 1 (<i>RTEL1</i>) mutations are associated with heterogeneous pulmonary and extra-pulmonary phenotypes Open
Regulator of telomere length 1 ( RTEL1 ) mutations have been evidenced in 5–9% of familial pulmonary fibrosis; however, the phenotype of patients with interstitial lung disease (ILD) and RTEL1 mutations is poorly understood. Whole exome se…
View article: Macrophage Polarization Favors Epithelial Repair During Acute Respiratory Distress Syndrome*
Macrophage Polarization Favors Epithelial Repair During Acute Respiratory Distress Syndrome* Open
Objectives: Alveolar macrophage polarization and role on alveolar repair during human acute respiratory distress syndrome remain unclear. This study aimed to determine during human acute respiratory distress syndrome: the alveolar macropha…
View article: Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells Open
Silver nanoparticles (AgNPs) are microbicidal agents which could be potentially used as an alternative to antivirals to treat human infectious diseases, especially influenza virus infections where antivirals have generally proven unsuccess…
View article: The pro-apoptotic BAX protein influences cell growth and differentiation from the nucleus in healthy interphasic cells
The pro-apoptotic BAX protein influences cell growth and differentiation from the nucleus in healthy interphasic cells Open
It has become more and more evident that the BCL-2 family proteins mediate a wide range of non-apoptotic functions. The pro-apoptotic BAX protein has been reported in interphasic nuclei. Whether the nuclear form of BAX could be involved in…
View article: Licence to kill senescent cells in idiopathic pulmonary fibrosis?
Licence to kill senescent cells in idiopathic pulmonary fibrosis? Open
Idiopathic pulmonary fibrosis (IPF) is a rare chronic fibrotic pulmonary disease of unknown aetiology, which results in the progressive destruction of lung with a very poor median survival of 3 years after diagnosis. According to the curre…
View article: FGF9 prevents pleural fibrosis induced by intrapleural adenovirus injection in mice
FGF9 prevents pleural fibrosis induced by intrapleural adenovirus injection in mice Open
Fibroblast growth factor 9 (FGF9) is necessary for fetal lung development and is expressed by epithelium and mesothelium. We evaluated the role of FGF9 overexpression on adenoviral-induced pleural injury in vivo and determined the biologic…
View article: Human airway trypsin-like protease, a serine protease involved in respiratory diseases
Human airway trypsin-like protease, a serine protease involved in respiratory diseases Open
More than 2% of all human genes are coding for a complex system of more than 700 proteases and protease inhibitors. Among them, serine proteases play extraordinary, diverse functions in different physiological and pathological processes. T…
View article: The pro-apoptotic BAX protein influences cell growth and differentiation from the nucleus in healthy interphasic cells
The pro-apoptotic BAX protein influences cell growth and differentiation from the nucleus in healthy interphasic cells Open
It has become more and more evident that the BCL-2 family proteins mediate a wide range of non-apoptotic functions. The pro-apoptotic BAX protein has been reported in interphasic nuclei. Whether the nuclear form of BAX could be involved in…
View article: Transcription factor PRRX1 is a master-regulator of IPF fibroblasts
Transcription factor PRRX1 is a master-regulator of IPF fibroblasts Open
View article: Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study
Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study Open
View article: Serum Amyloid P Contained in Alveolar Fluid From Patients With Acute Respiratory Distress Syndrome Mediates the Inhibition of Monocyte Differentiation into Fibrocyte
Serum Amyloid P Contained in Alveolar Fluid From Patients With Acute Respiratory Distress Syndrome Mediates the Inhibition of Monocyte Differentiation into Fibrocyte Open
Objective: Alveolar fibrocytes are monocyte-derived mesenchymal cells associated with poor prognosis in patients with acute respiratory distress syndrome. Our aims were to determine the following: 1) the ability of monocytes from acute res…