Arnaud Mansart
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View article: Nanoparticle-based approaches for sepsis treatment: Current trends and perspectives
Nanoparticle-based approaches for sepsis treatment: Current trends and perspectives Open
Sepsis is a devastating syndrome resulting from organ dysfunction caused by a dysregulated host response to infection. The management of patients is currently primarily based on controlling the infection and restoring cardiovascular/respir…
View article: Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury
Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury Open
This study investigates the potential of pulmonary delivery of siRNA as an emergency therapy for acute lung injury (ALI). To obtain a quick anti‐inflammatory response, TNF‐α, a critical pro‐inflammatory cytokine, is knocked down for its ea…
View article: Unveiling Distinct Neuroimmune Responses in Mouse Models of Cervical Spinal Cord Injury: Hemisection versus Hemicontusion
Unveiling Distinct Neuroimmune Responses in Mouse Models of Cervical Spinal Cord Injury: Hemisection versus Hemicontusion Open
Traumatic cervical spinal cord injury (cSCI) causes severe neurological deficits and long-term disability. Preclinical models such as cervical 2 (C2) hemisection (C2HS), resulting in disrupted communication between the respiratory centers …
View article: rTMS induces respiratory neuroplasticity in a preclinical model of spinal cord injury
rTMS induces respiratory neuroplasticity in a preclinical model of spinal cord injury Open
View article: Diaphragm ultrasound and diaphragmatic 2D speckle tracking imaging in acute heart failure: a case series
Diaphragm ultrasound and diaphragmatic 2D speckle tracking imaging in acute heart failure: a case series Open
Background Respiratory muscle function can be affected in patients with heart failure. Ultrasound can be used to assess diaphragm, the main inspiratory muscle. Speckle tracking imaging is an imaging technology providing the evaluation of t…
View article: Glycolytic metabolism modulation on spinal neuroinflammation and vital functions following cervical spinal cord injury
Glycolytic metabolism modulation on spinal neuroinflammation and vital functions following cervical spinal cord injury Open
High spinal cord injuries (SCIs) often result in persistent diaphragm paralysis and respiratory dysfunction. Chronic neuroinflammation within the damaged spinal cord after injury plays a prominent role in limiting functional recovery by im…
View article: ß1-adrenergic blockers preserve neuromuscular function by inhibiting the production of extracellular traps during systemic inflammation in mice
ß1-adrenergic blockers preserve neuromuscular function by inhibiting the production of extracellular traps during systemic inflammation in mice Open
Severe inflammation via innate immune system activation causes organ dysfunction. Among these, the central nervous system (CNS) is particularly affected by encephalopathies. These symptoms are associated with the activation of microglia an…
View article: A druggable copper-signalling pathway that drives inflammation
A druggable copper-signalling pathway that drives inflammation Open
View article: Oligonucleotide Enhancing Compound Increases Tricyclo-DNA Mediated Exon-Skipping Efficacy in the Mdx Mouse Model
Oligonucleotide Enhancing Compound Increases Tricyclo-DNA Mediated Exon-Skipping Efficacy in the Mdx Mouse Model Open
Nucleic acid-based therapeutics hold great promise for the treatment of numerous diseases, including neuromuscular disorders, such as Duchenne muscular dystrophy (DMD). Some antisense oligonucleotide (ASO) drugs have already been approved …
View article: Extracellular traps formation following cervical spinal cord injury
Extracellular traps formation following cervical spinal cord injury Open
Spinal cord injuries involve a primary injury that can lead to permanent loss of function and a secondary injury associated with pathologic and inflammatory processes. Extracellular traps are extracellular structures expressed by immune ce…
View article: Evaluation of Gastrocnemius Motor Evoked Potentials Induced by Trans-Spinal Magnetic Stimulation Following Tibial Nerve Crush in Rats
Evaluation of Gastrocnemius Motor Evoked Potentials Induced by Trans-Spinal Magnetic Stimulation Following Tibial Nerve Crush in Rats Open
Peripheral nerve injuries induce long-lasting physiological and severe functional impairment due to motor, sensory, and autonomic denervation. Preclinical models allow us to study the process of nerve damage, evaluate the capacity of the p…
View article: Effect of an enteral amino acid blend on muscle and gut functionality in critically ill patients: a proof-of-concept randomized controlled trial
Effect of an enteral amino acid blend on muscle and gut functionality in critically ill patients: a proof-of-concept randomized controlled trial Open
View article: Effects of C2 hemisection on respiratory and cardiovascular functions in rats
Effects of C2 hemisection on respiratory and cardiovascular functions in rats Open
High cervical spinal cord injuries induce permanent neuromotor and autonomic deficits. These injuries impact both central respiratory and cardiovascular functions through modulation of the sympathetic nervous system. So far, cardiovascular…
View article: Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients
Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients Open
Background. The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis. They could be a “second hit” of an inflammatory event such as infection. The ai…
View article: Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation
Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation Open
Inflammation is a complex physiological process triggered in response to harmful stimuli. It involves specialized cells of the immune system able to clear sources of cell injury and damaged tissues to promote repair. Excessive inflammation…
View article: Effects of Chronic High-Frequency rTMS Protocol on Respiratory Neuroplasticity Following C2 Spinal Cord Hemisection in Rats
Effects of Chronic High-Frequency rTMS Protocol on Respiratory Neuroplasticity Following C2 Spinal Cord Hemisection in Rats Open
High spinal cord injuries (SCIs) lead to permanent diaphragmatic paralysis. The search for therapeutics to induce functional motor recovery is essential. One promising noninvasive therapeutic tool that could harness plasticity in a spared …
View article: CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype
CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype Open
View article: High frequency repetitive Transcranial Magnetic Stimulation promotes long lasting phrenic motoneuron excitability via GABAergic networks
High frequency repetitive Transcranial Magnetic Stimulation promotes long lasting phrenic motoneuron excitability via GABAergic networks Open
View article: Analysis of inspiratory and expiratory muscles using ultrasound in rats: A reproducible and non-invasive tool to study respiratory function
Analysis of inspiratory and expiratory muscles using ultrasound in rats: A reproducible and non-invasive tool to study respiratory function Open
View article: Permanent diaphragmatic deficits and spontaneous respiratory plasticity in a mouse model of incomplete cervical spinal cord injury
Permanent diaphragmatic deficits and spontaneous respiratory plasticity in a mouse model of incomplete cervical spinal cord injury Open
View article: Diaphragm: Pathophysiology and Ultrasound Imaging in Neuromuscular Disorders
Diaphragm: Pathophysiology and Ultrasound Imaging in Neuromuscular Disorders Open
Respiratory muscles are classically involved in neuromuscular disorders, leading to a restrictive respiratory pattern. The diaphragm is the main respiratory muscle involved during inspiration. Ultrasound imaging is a noninvasive, radiation…