Laurent Arnaud
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View article: Comparison of Technical Performance and Biological Quality of Nanofat From Eight Commercial Preparation Systems Using a Scoring Approach in a Single Donor Model
Comparison of Technical Performance and Biological Quality of Nanofat From Eight Commercial Preparation Systems Using a Scoring Approach in a Single Donor Model Open
Background: Nanofat is a relatively recent fat grafting technique obtained involving the mechanical emulsification of adipose tissue whose preparation is produced at the patient’s bedside. Although it was initially reported to improve skin…
View article: Disease progression in patients with systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort Study (SPOCS)
Disease progression in patients with systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort Study (SPOCS) Open
Objectives We describe disease progression in patients from the SLE Prospective Observational Cohort Study (SPOCS; NCT03189875), investigating differences by baseline IFN gene signature (IFNGS) status. Methods Adults with moderate to sever…
View article: Comparative efficacy and safety of anakinra and canakinumab in patients with <scp>VEXAS</scp> syndrome – an international multicenter study
Comparative efficacy and safety of anakinra and canakinumab in patients with <span>VEXAS</span> syndrome – an international multicenter study Open
Objectives The aim of this study was to compare differences in clinical response, drug survival, and adverse event rates between anakinra and canakinumab in VEXAS syndrome. Methods This multicenter international study includes VEXAS patien…
View article: Pneumococcal and influenza vaccination coverage and impact on COVID-19 infection severity in patients with inflammatory rheumatic diseases: A French National Healthcare Database analysis
Pneumococcal and influenza vaccination coverage and impact on COVID-19 infection severity in patients with inflammatory rheumatic diseases: A French National Healthcare Database analysis Open
Pneumococcal vaccination was associated with a reduced hospitalization rate, and occurrence of severe forms of COVID-19, including death, among infected patients. These findings suggest the possible involvement of vaccine-induced trained i…
View article: OP0040 Trajectory and Determinants of Organ Damage Accrual in Behçet's Syndrome: 1-Year Preliminary Results from the PROBE Study
OP0040 Trajectory and Determinants of Organ Damage Accrual in Behçet's Syndrome: 1-Year Preliminary Results from the PROBE Study Open
View article: The Procoagulant and Fibrinolytic Balance of Extracellular Vesicles Predicts Mortality in Septic Shock Patients
The Procoagulant and Fibrinolytic Balance of Extracellular Vesicles Predicts Mortality in Septic Shock Patients Open
Septic shock is characterised by abnormal coagulation activation with defective fibrinolysis, leading to a high mortality rate. Cellular activation triggers the release of extracellular vesicles (EVs) conveying both procoagulant and fibrin…
View article: POS1155 IMPROVEMENT OF FATIGUE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS TREATED WITH DAPIROLIZUMAB PEGOL: 48-WEEK RESULTS FROM A PHASE 3 TRIAL
POS1155 IMPROVEMENT OF FATIGUE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS TREATED WITH DAPIROLIZUMAB PEGOL: 48-WEEK RESULTS FROM A PHASE 3 TRIAL Open
View article: POS0383 IL-1 INHIBITION IN PATIENTS WITH VEXAS SYNDROME – A RETROSPECTIVE INTERNATIONAL MULTICENTER STUDY
POS0383 IL-1 INHIBITION IN PATIENTS WITH VEXAS SYNDROME – A RETROSPECTIVE INTERNATIONAL MULTICENTER STUDY Open
View article: OP0033 Interstitial Lung Disease (ILD)-associated mortality in French patients with Connective Tissue Diseases: a Nation-wide population-based study
OP0033 Interstitial Lung Disease (ILD)-associated mortality in French patients with Connective Tissue Diseases: a Nation-wide population-based study Open
View article: Hyper-resolution decametric modelling of alpine catchments: development of a data processing framework to represent small scale-snow hydrological processes, over complex topography
Hyper-resolution decametric modelling of alpine catchments: development of a data processing framework to represent small scale-snow hydrological processes, over complex topography Open
Mountain ecosystems are under increasing pressure from anthropogenic forcings including warming, precipitation change and nutrient inputs. Understanding and projecting the consequences of these changes requires to be able to model transfer…
View article: LIVING WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN 2024: LATIN AMERICAN EXPERIENCE BASED ON A PATIENT SURVEY
LIVING WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN 2024: LATIN AMERICAN EXPERIENCE BASED ON A PATIENT SURVEY Open
PV169 / #263 Poster Topic: AS19 - Patient-Reported Outcome Measures Background/Purpose Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that significantly impacts patients’ quality of life. In 2020, a survey was conducte…
View article: DEVELOPMENT OF A NOVEL FRAMEWORK TO INFORM COST-EFFECTIVENESS MODELS IN SYSTEMIC LUPUS ERYTHEMATOSUS
DEVELOPMENT OF A NOVEL FRAMEWORK TO INFORM COST-EFFECTIVENESS MODELS IN SYSTEMIC LUPUS ERYTHEMATOSUS Open
PV094 / #450 Poster Topic: AS11 - Epidemiology and Public Health Background/Purpose Cost-effectiveness models (CEMs) play a significant role in health technology assessments (HTAs). However, existing CEMs for systemic lupus erythematosus (…
View article: European Reference Network (ERN) ReCONNET methodology for the cross-cultural adaptation of instruments for research and care in the context of rare connective tissue diseases (CROSSADAPT)
European Reference Network (ERN) ReCONNET methodology for the cross-cultural adaptation of instruments for research and care in the context of rare connective tissue diseases (CROSSADAPT) Open
View article: Scoping literature review to identify candidate domains for the OMERACT Systemic Lupus Erythematosus core outcome set
Scoping literature review to identify candidate domains for the OMERACT Systemic Lupus Erythematosus core outcome set Open
The 25 candidate domains cover the important aspects of SLE and the 4 core areas of disease impact according to OMERACT framework. The 25 candidate domains constitute a feasible and manageable number of domains to proceed with to the core …
View article: Real-world oral glucocorticoid use in SLE: a nation-wide population-based study using the French medico-administrative (SNDS) claim database
Real-world oral glucocorticoid use in SLE: a nation-wide population-based study using the French medico-administrative (SNDS) claim database Open
Background Oral glucocorticoids (OCS) remain one of the most important treatments for SLE but are associated with damage. Evidence regarding the real-world use of OCS in nationwide SLE populations is currently lacking. The aim of this stud…
View article: Interferon-α biological activity is associated with disease activity and risk of flare in cutaneous lupus erythematosus: A monocentric study of 184 patients
Interferon-α biological activity is associated with disease activity and risk of flare in cutaneous lupus erythematosus: A monocentric study of 184 patients Open
View article: Caspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients
Caspase-1 activation, IL-1/IL-6 signature and IFNγ-induced chemokines in lungs of COVID-19 patients Open
Rationale COVID-19-associated acute-respiratory distress syndrome (C-ARDS) results from a direct viral injury associated with host excessive innate immune response mainly affecting the lungs. However, cytokine profile in the lung compartme…
View article: Detection of Mercury Ions at ng/L Scale by Surface Plasmon Resonance (SPR) on DNA Aptamer Biochips
Detection of Mercury Ions at ng/L Scale by Surface Plasmon Resonance (SPR) on DNA Aptamer Biochips Open
International audience
View article: Domains for inclusion in a novel Treatment Response Measure for Systemic Lupus Erythematosus (TRM-SLE): results of a modified Delphi study
Domains for inclusion in a novel Treatment Response Measure for Systemic Lupus Erythematosus (TRM-SLE): results of a modified Delphi study Open
Objectives To achieve consensus on domains of active disease for inclusion in a novel outcome measure for SLE randomised controlled trials (RCTs), the Treatment Response Measure for SLE (TRM-SLE). Methods Domains nominated by TRM-SLE Taskf…
View article: Levels of physical activity in a large international cohort of patients with systemic lupus erythematosus
Levels of physical activity in a large international cohort of patients with systemic lupus erythematosus Open
Introduction Physical activity (PA) holds a pivotal role in the improvement of mental health or depressive symptoms, as well as in the prevention of cardiovascular diseases (CVDs). Patients with SLE are exposed to an increased risk of CVDs…
View article: Real-world treatment patterns and clinical characteristics in patients with moderate-to-severe systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort Study (SPOCS)
Real-world treatment patterns and clinical characteristics in patients with moderate-to-severe systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort Study (SPOCS) Open
Objectives Systemic lupus erythematosus (SLE) is a disease with heterogeneous treatment patterns largely based on organ involvement and disease severity. The SLE Prospective Observational Cohort Study (SPOCS) collected data worldwide over …
View article: Deucravacitinib, an oral, selective, allosteric, tyrosine kinase 2 inhibitor, in patients with active SLE: efficacy on patient-reported outcomes in a phase II randomised trial
Deucravacitinib, an oral, selective, allosteric, tyrosine kinase 2 inhibitor, in patients with active SLE: efficacy on patient-reported outcomes in a phase II randomised trial Open
Objective In PAISLEY, a 48-week, phase II, randomised controlled trial that assessed deucravacitinib in patients with active SLE, all primary and secondary endpoints were met with the deucravacitinib 3 mg two times per day dose. Changes in…
View article: Identifying meaningful aspects of health and concepts of interest for assessment in systemic lupus erythematosus: implications for digital clinical measure development
Identifying meaningful aspects of health and concepts of interest for assessment in systemic lupus erythematosus: implications for digital clinical measure development Open
Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with heterogeneous clinical manifestations which significantly impacts the daily lives of patients. Herein, we aimed to (i) investigate patients’ perspectives on…
View article: Nonischemic Cardiac Manifestations in VEXAS Syndrome
Nonischemic Cardiac Manifestations in VEXAS Syndrome Open
This case series reports on the clinical presentation, laboratory findings, imaging characteristics, treatments, and outcomes of nonischemic cardiac manifestations in patients with VEXAS syndrome with confirmed pathogenic UBA1 alterations.
View article: Prevalence and characteristics of, and knowledge related to, photosensitivity in patients with lupus erythematosus: the international PHOTOLUP study.
Prevalence and characteristics of, and knowledge related to, photosensitivity in patients with lupus erythematosus: the international PHOTOLUP study. Open
A high rate of self-reported photosensitivity characterizes lupus erythematosus patients. Photosensitivity frequently includes subjective features, which makes it difficult to evaluate in clinical practice. As fatigue is frequent in lupus …
View article: The pipeline of immunomodulatory therapies in polymyalgia rheumatica and giant cell arteritis: A systematic review of clinical trials
The pipeline of immunomodulatory therapies in polymyalgia rheumatica and giant cell arteritis: A systematic review of clinical trials Open
This systematic review identified 23 DMARDs evaluated for PMR and GCA: 3 csDMARDs, 17 bDMARDs and 3 tsDMARDs. Several promising treatments are likely to be marketed in the coming years.
View article: Challenges and opportunities in access to care for systemic lupus erythematosus patients across Europe and worldwide
Challenges and opportunities in access to care for systemic lupus erythematosus patients across Europe and worldwide Open
SLE presents significant challenges for patients and health-care professionals (HCPs), both across Europe and worldwide. Improving health-care outcomes for patients with SLE requires a comprehensive understanding of patient disease pathway…
View article: Vascular endothelial-cadherin is involved in endothelial cell detachment during thrombotic thrombocytopenic purpura
Vascular endothelial-cadherin is involved in endothelial cell detachment during thrombotic thrombocytopenic purpura Open
View article: Recommendations for physical activity and exercise in persons living with Systemic Lupus Erythematosus (SLE): consensus by an international task force
Recommendations for physical activity and exercise in persons living with Systemic Lupus Erythematosus (SLE): consensus by an international task force Open
Objective This international task force aimed to provide healthcare professionals and persons living with systemic lupus erythematosus (SLE) with consensus-based recommendations for physical activity and exercise in SLE. Methods Based on e…
View article: LC3-associated phagocytosis is impaired in monocyte-derived macrophages from systemic sclerosis patients
LC3-associated phagocytosis is impaired in monocyte-derived macrophages from systemic sclerosis patients Open
Autophagy is a fundamental catabolic process performed by a network of autophagy related (ATG) proteins. Some ATG proteins coordinate parallel roles in so-called “noncanonical” autophagy such as LC3-associated phagocytosis (LAP). Both auto…