Arnaud Taton
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View article: Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery
Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery Open
Cyanobacteria are prolific producers of bioactive natural products. In this article, we outline some challenges faced in exploiting cyanobacteria for drug discovery, current solutions, and pathways forward to fully explore them for drug di…
View article: <i>Synechococcus elongatus</i> Argonaute reduces natural transformation efficiency and provides immunity against exogenous plasmids
<i>Synechococcus elongatus</i> Argonaute reduces natural transformation efficiency and provides immunity against exogenous plasmids Open
The cyanobacterium Synechococcus elongatus PCC 7942 produces an active prokaryotic Argonaute nuclease, SeAgo, whose function is unknown. Here, we show that SeAgo reduces natural transformation and prevents the maintenance of RSF1010 replic…
View article: Effects of RuBisCO and CO <sub>2</sub> concentration on cyanobacterial growth and carbon isotope fractionation
Effects of RuBisCO and CO <sub>2</sub> concentration on cyanobacterial growth and carbon isotope fractionation Open
Carbon isotope biosignatures preserved in the Precambrian geologic record are primarily interpreted to reflect ancient cyanobacterial carbon fixation catalyzed by Form I RuBisCO enzymes. The average range of isotopic biosignatures generall…
View article: An unexpected role for leucyl aminopeptidase in UV tolerance revealed by a genome-wide fitness assessment in a model cyanobacterium
An unexpected role for leucyl aminopeptidase in UV tolerance revealed by a genome-wide fitness assessment in a model cyanobacterium Open
UV radiation (UVR) has significant physiological effects on organisms living at or near the Earth’s surface, yet the full suite of genes required for fitness of a photosynthetic organism in a UVR-rich environment remains unknown. This stud…
View article: Resurrected Rubisco suggests uniform carbon isotope signatures over geologic time
Resurrected Rubisco suggests uniform carbon isotope signatures over geologic time Open
The earliest geochemical indicators of microbes-and the enzymes that powered them-extend back ∼3.8 Ga on Earth. Paleobiologists often attempt to understand these indicators by assuming that the behaviors of extant microbes and enzymes are …
View article: Resurrected Rubisco suggests uniform carbon isotope signatures over geologic time
Resurrected Rubisco suggests uniform carbon isotope signatures over geologic time Open
Summary The earliest geochemical indicators of microbes—and the enzymes that powered them—extend back almost 3.8 billion years on our planet. Paleobiologists often attempt to understand these indicators by assuming that the behaviors of mo…
View article: Effects of CO<sub>2</sub>and RuBisCO concentration on cyanobacterial growth and carbon isotope fractionation
Effects of CO<sub>2</sub>and RuBisCO concentration on cyanobacterial growth and carbon isotope fractionation Open
Carbon isotope biosignatures preserved in the Precambrian geologic record are primarily interpreted to reflect ancient cyanobacterial carbon fixation catalyzed by Form I RuBisCO enzymes. The average range of isotopic biosignatures generall…
View article: Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host
Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host Open
Filamentous marine cyanobacteria make a variety of bioactive molecules that are produced by polyketide synthases, nonribosomal peptide synthetases, and hybrid pathways that are encoded by large biosynthetic gene clusters. These cyanobacter…
View article: Heterologous expression of cryptomaldamide in a cyanobacterial host
Heterologous expression of cryptomaldamide in a cyanobacterial host Open
Filamentous marine cyanobacteria make a variety of bioactive molecules that are produced by polyketide synthases, non-ribosomal peptide synthetases, and hybrid pathways that are encoded by large biosynthetic gene clusters. These cyanobacte…
View article: The circadian clock and darkness control natural competence in cyanobacteria
The circadian clock and darkness control natural competence in cyanobacteria Open
The cyanobacterium Synechococcus elongatus is a model organism for the study of circadian rhythms. It is naturally competent for transformation—that is, it takes up DNA from the environment, but the underlying mechanisms are unclear. Here,…
View article: Expression of Heterologous OsDHAR Gene Improves Glutathione (GSH)-Dependent Antioxidant System and Maintenance of Cellular Redox Status in Synechococcus elongatus PCC 7942
Expression of Heterologous OsDHAR Gene Improves Glutathione (GSH)-Dependent Antioxidant System and Maintenance of Cellular Redox Status in Synechococcus elongatus PCC 7942 Open
An excess of reactive oxygen species (ROS) can cause severe oxidative damage to cellular components in photosynthetic cells. Antioxidant systems, such as the glutathione (GSH) pools, regulate redox status in cells to guard against such dam…
View article: The circadian clock and darkness control natural competence in cyanobacteria
The circadian clock and darkness control natural competence in cyanobacteria Open
Natural genetic competence-based transformation contributed to the evolution of prokaryotes, including the cyanobacterial phylum that established oxygenic photosynthesis. The cyanobacterium Synechococcus elongatus is noted both as a model …
View article: Phototaxis in a wild isolate of the cyanobacterium <i>Synechococcus elongatus</i>
Phototaxis in a wild isolate of the cyanobacterium <i>Synechococcus elongatus</i> Open
Many cyanobacteria, which use light as an energy source via photosynthesis, have evolved the ability to guide their movement toward or away from a light source. This process, termed “phototaxis,” enables organisms to localize in optimal li…
View article: Expression of OsTPX Gene Improves Cellular Redox Homeostasis and Photosynthesis Efficiency in Synechococcus elongatus PCC 7942
Expression of OsTPX Gene Improves Cellular Redox Homeostasis and Photosynthesis Efficiency in Synechococcus elongatus PCC 7942 Open
Cyanobacterial 2-Cys peroxiredoxin (thioredoxin peroxidase, TPX) comprises a family of thiol antioxidant enzymes critically involved in cell survival under oxidative stress. In our previous study, a putative TPX was identified using a prot…
View article: High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival
High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival Open
The broadly conserved signaling nucleotide cyclic di-adenosine monophosphate (c-di-AMP) is essential for viability in most bacteria where it has been studied. However, characterization of the cellular functions and metabolism of c-di-AMP h…
View article: NOT Gate Genetic Circuits to Control Gene Expression in Cyanobacteria
NOT Gate Genetic Circuits to Control Gene Expression in Cyanobacteria Open
To downregulate gene expression in cyanobacteria, we constructed NOT gate genetic circuits using orthogonal promoters and their cognate repressors regulated translationally by synthetic riboswitches. Four NOT gates were tested and characte…