Arnaud W. Thille
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View article: Association between respiratory-related cortical activation and weaning from mechanical ventilation: a physiological study
Association between respiratory-related cortical activation and weaning from mechanical ventilation: a physiological study Open
The demonstration of an association between increased respiratory-related cortical activation and failure of the weaning trial is a physiological marker of interest for better phenotyping of patients ready for weaning.
View article: Factors associated with ICU mortality and long-term outcomes in immunocompromised patients admitted to the intensive care unit for acute respiratory failure
Factors associated with ICU mortality and long-term outcomes in immunocompromised patients admitted to the intensive care unit for acute respiratory failure Open
View article: PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study
PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study Open
View article: Outcomes of Critically Ill Adult Patients With Acute Encephalitis
Outcomes of Critically Ill Adult Patients With Acute Encephalitis Open
Importance Functional outcomes and long-term recovery after severe encephalitis are not well characterized. Objective To determine the incidence of functional disability or death at 3 months and to describe recovery trajectories through 1 …
View article: Antifungal concentrations in mechanically ventilated COVID-19 patients with or without ECMO: The CAPADOSE observational retrospective multicenter Study
Antifungal concentrations in mechanically ventilated COVID-19 patients with or without ECMO: The CAPADOSE observational retrospective multicenter Study Open
Over half of CAPA patients had subtherapeutic antifungal levels, but ECMO did not significantly influence drug exposure.
View article: Noninvasive respiratory supports in ICU
Noninvasive respiratory supports in ICU Open
View article: How should spontaneous breathing trials be performed in the light of recent literature?
How should spontaneous breathing trials be performed in the light of recent literature? Open
View article: Renal replacement therapy in an intensive care unit: guidelines from the SRLF-GFRUP consensus conference
Renal replacement therapy in an intensive care unit: guidelines from the SRLF-GFRUP consensus conference Open
View article: Expert consensus‑based clinical practice guidelines for nutritional support in the intensive care unit: the French Intensive Care Society (SRLF) and the French-Speaking Group of Pediatric Emergency Physicians and Intensivists (GFRUP)
Expert consensus‑based clinical practice guidelines for nutritional support in the intensive care unit: the French Intensive Care Society (SRLF) and the French-Speaking Group of Pediatric Emergency Physicians and Intensivists (GFRUP) Open
The objective of this work was to develop guidelines for nutritional support in critically ill adults and children (excluding neonates and burn patients) unable to maintain an adequate oral intake. We aimed to provide up-to-date recommenda…
View article: Noninvasive respiratory supports for acute hypoxemic respiratory failure
Noninvasive respiratory supports for acute hypoxemic respiratory failure Open
View article: Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial
Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial Open
In patients at high-risk of extubation failure, prophylactic NIV significantly decreased inspiratory efforts with increased tidal volumes compared to HFNO. The clinical benefits of NIV to prevent reintubation in patients at high-risk may b…
View article: Mean arterial pressure after out-of-hospital cardiac arrest (METAPHORE): study protocol for a multicentre controlled trial with blinded primary outcome assessor
Mean arterial pressure after out-of-hospital cardiac arrest (METAPHORE): study protocol for a multicentre controlled trial with blinded primary outcome assessor Open
Introduction Out-of-hospital cardiac arrest is a public health concern with a high mortality rate. Hypoxic ischaemic brain injury is the primary cause of death in patients admitted to the intensive care unit (ICU) after return of spontaneo…
View article: Early bacterial co-infections and ventilator-associated lower respiratory tract infections among intubated patients during the first and second COVID-19 waves: a European comparative cohort study
Early bacterial co-infections and ventilator-associated lower respiratory tract infections among intubated patients during the first and second COVID-19 waves: a European comparative cohort study Open
Between the first and second COVID-19 waves, the prevalence of early bacterial pulmonary co-infections significantly increased among intubated patients. Although the overall incidence of VA-LRTI remained stable, there was a significant shi…
View article: Correction: Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure
Correction: Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure Open
View article: Applying positive end-expiratory pressure before and during endotracheal tube removal versus extubation with concomitant aspiration: protocol for the randomised controlled multicentre EXSUPEEP trial
Applying positive end-expiratory pressure before and during endotracheal tube removal versus extubation with concomitant aspiration: protocol for the randomised controlled multicentre EXSUPEEP trial Open
Introduction The optimal method for removing the endotracheal tube (ETT) during extubation in the intensive care unit (ICU) remains uncertain. Two methods are described for removing the ETT in ICU, namely the ‘Traditional technique’ with c…
View article: Best clinical model predicting extubation failure: a diagnostic accuracy post hoc analysis
Best clinical model predicting extubation failure: a diagnostic accuracy post hoc analysis Open
View article: Prophylactic Noninvasive Ventilation after Extubation of Obese Patients
Prophylactic Noninvasive Ventilation after Extubation of Obese Patients Open
View article: A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study
A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study Open
View article: Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations
Emergence of cefiderocol resistance during therapy in NDM-5–producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations Open
View article: Advantages of Metabolomics-Based Multivariate Machine Learning to Predict Disease Severity: Example of COVID
Advantages of Metabolomics-Based Multivariate Machine Learning to Predict Disease Severity: Example of COVID Open
The COVID-19 outbreak caused saturations of hospitals, highlighting the importance of early patient triage to optimize resource prioritization. Herein, our objective was to test if high definition metabolomics, combined with ML, can improv…
View article: Oxygen therapy and noninvasive respiratory supports in acute hypoxemic respiratory failure: a narrative review
Oxygen therapy and noninvasive respiratory supports in acute hypoxemic respiratory failure: a narrative review Open
View article: Impact of sleep disturbances on outcomes in intensive care units
Impact of sleep disturbances on outcomes in intensive care units Open
View article: Effect of high-flow nasal cannula oxygen versus standard oxygen on mortality in patients with acute hypoxaemic respiratory failure: protocol for a multicentre, randomised controlled trial (SOHO)
Effect of high-flow nasal cannula oxygen versus standard oxygen on mortality in patients with acute hypoxaemic respiratory failure: protocol for a multicentre, randomised controlled trial (SOHO) Open
Introduction First-line oxygenation strategy in patients with acute hypoxaemic respiratory failure consists in standard oxygen or high-flow nasal oxygen therapy. Clinical practice guidelines suggest the use of high-flow nasal oxygen rather…
View article: Pressure control plus spontaneous ventilation versus volume assist-control ventilation in acute respiratory distress syndrome. A randomised clinical trial
Pressure control plus spontaneous ventilation versus volume assist-control ventilation in acute respiratory distress syndrome. A randomised clinical trial Open
View article: Impact of sleep disturbances on outcomes in intensive care units
Impact of sleep disturbances on outcomes in intensive care units Open
Background Sleep deprivation is common in ICUs and may alter respiratory performance. Few studies have assessed the role of sleep disturbances on outcomes in critically ill patients. Objectives We hypothesized that sleep disturbances may b…
View article: A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study.
A worldwide assessment of the mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease. Analysis of the VENTILAGROUP over time. A retrospective, multicenter study. Open
Background The trend overtime and across different geographical areas of outcomes and management with noninvasive ventilation or invasive mechanical ventilation in patients admitted for acute exacerbations of chronic obstructive pulmonary …
View article: Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19
Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19 Open
View article: Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure
Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure Open
View article: Pressure versus volume assist-control ventilation in Acute Respiratory Distress Syndrome: a randomised clinical trial.
Pressure versus volume assist-control ventilation in Acute Respiratory Distress Syndrome: a randomised clinical trial. Open
Background: To compare the effect of a pressure-controlled strategy allowing non-synchronized unassisted spontaneous ventilation (PC-SV) to a conventional volume assist-control strategy (ACV) on the outcome of patients with Acute Respirato…
View article: Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis
Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis Open
Background Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly related to Enterobacteral…