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View article: Heterogeneity of treatment preferences in the absence of guideline recommendations – a case vignette study in colorectal cancer tumor boards in Germany, Austria and Switzerland
Heterogeneity of treatment preferences in the absence of guideline recommendations – a case vignette study in colorectal cancer tumor boards in Germany, Austria and Switzerland Open
View article: Prognostic impact of lymph node count features in total laryngectomy for advanced laryngeal squamous cell carcinoma
Prognostic impact of lymph node count features in total laryngectomy for advanced laryngeal squamous cell carcinoma Open
Introduction The optimal surgical management in advanced laryngeal squamous cell carcinoma (ALSCC) is still under debate. The extent of neck dissection as well as the nodal involvement affect survival metrics in head and neck cancer (HNSCC…
View article: Acute mastoiditis in pediatric cochlear implant patients – a systematic review
Acute mastoiditis in pediatric cochlear implant patients – a systematic review Open
Acute mastoiditis (AM) is a rare but potentially life-threatening condition in pediatric patients, particularly those with cochlear implants (CI) seem to be at higher risk for complications. The aim of this study is to propose a diagnostic…
View article: Effiziente Planung der Schlafendoskopie vor atmungsabhängiger unilateraler Zungenschrittmacherimplantation
Effiziente Planung der Schlafendoskopie vor atmungsabhängiger unilateraler Zungenschrittmacherimplantation Open
View article: Infrared Laser Sampling of Low Volumes Reveals Marker Lipids in Palatine Tonsil Carcinoma via Shotgun Lipidomics
Infrared Laser Sampling of Low Volumes Reveals Marker Lipids in Palatine Tonsil Carcinoma via Shotgun Lipidomics Open
Complete surgical resection is essential for oropharyngeal squamous cell carcinoma (OPSCC) therapy, underscoring the need for improved intraoperative margin assessment. To advance in-vivo diagnostics of OPSCC, Nanosecond infrared laser (NI…
View article: Massive Solitary Fibrous Tumor of the Hypopharynx
Massive Solitary Fibrous Tumor of the Hypopharynx Open
View article: 26MO Tumor tissue slices: A powerful translational tool for refining (radio-)therapy in HPV/p16-positive oropharyngeal and sinonasal squamous cell carcinoma
26MO Tumor tissue slices: A powerful translational tool for refining (radio-)therapy in HPV/p16-positive oropharyngeal and sinonasal squamous cell carcinoma Open
View article: An unusual clinical presentation of a plunging ranula—The plunging ranula with extension to the vallecula
An unusual clinical presentation of a plunging ranula—The plunging ranula with extension to the vallecula Open
Key Clinical Message A plunging ranula may present initially as an extensive vallecular cyst and correct diagnosis may be reached with the use of ultrasound, fluid aspiration for amylase detection, and MRI imaging. Abstract The ranula is a…
View article: The “fascia taco” for nasal septum perforation closure—A retrospective Cohort study on success rates and patient reported outcomes
The “fascia taco” for nasal septum perforation closure—A retrospective Cohort study on success rates and patient reported outcomes Open
Objective Nasal septum perforation (NSP) is a common condition affecting ~1.2% of the general population and is still considered challenging to treat. Therapeutic strategies range from conservative local treatments and septal button closur…
View article: Wieviel Digitalisierung braucht die HNO-Lehre?
Wieviel Digitalisierung braucht die HNO-Lehre? Open
Zusammenfassung Hintergrund Digitalisierung ist längst fester Bestandteil des Alltags von Studierenden und zunehmend auch ihrer medizinischen Ausbildung. Es scheint ein ungeschriebenes Gesetz zu sein, dass „digital natives“ möglichst viel …
View article: Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck
Outcomes following oropharyngeal squamous cell carcinoma resection and bilateral neck dissection with or without contralateral postoperative radiotherapy of the pathologically node-negative neck Open
Purpose There are no consensus guidelines regarding the postoperative treatment of the contralateral pathologically node-negative neck in oropharyngeal squamous cell carcinoma. This study aimed to determine if omission of postoperative irr…
View article: Lipidome Analysis of Oropharyngeal Tumor Tissues Using Nanosecond Infrared Laser (NIRL) Tissue Sampling and Subsequent Mass Spectrometry
Lipidome Analysis of Oropharyngeal Tumor Tissues Using Nanosecond Infrared Laser (NIRL) Tissue Sampling and Subsequent Mass Spectrometry Open
Ultrashort pulse infrared lasers can simultaneously sample and homogenize biological tissue using desorption by impulsive vibrational excitation (DIVE). With growing attention on alterations in lipid metabolism in malignant disease, mass s…
View article: Pre‐clinical evaluation of APrevent® VOIS for unilateral vocal fold paralysis medialization
Pre‐clinical evaluation of APrevent® VOIS for unilateral vocal fold paralysis medialization Open
Objective To evaluate the concept and efficacy of an adjustable implant (Prototype SH30: porcine implant and APrevent® VOIS: human concept) for treatment of unilateral vocal fold paralysis (UVFP) via in vivo mini‐pig studies, human compute…
View article: Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1
Impaired DNA double-strand break repair and effective radiosensitization of HPV-negative HNSCC cell lines through combined inhibition of PARP and Wee1 Open
View article: An Accessory Muscle Originating From the Hyoid Bone and Inserting Into the Sternocleidomastoid Muscle
An Accessory Muscle Originating From the Hyoid Bone and Inserting Into the Sternocleidomastoid Muscle Open
Irregular bellies and insertions into neck muscles have been described in the literature. To the best of our knowledge, a right accessory muscle originating from the hyoid bone and inserting into the sternocleidomastoid muscle has not been…
View article: Anmerkungen zum Terminus „Drainage“
Anmerkungen zum Terminus „Drainage“ Open
View article: Is Vestibular Neuropathy Rather a Neuritis?
Is Vestibular Neuropathy Rather a Neuritis? Open
View article: Radiosensibilisierung durch duale Inhibition von Wee1 und PARP in ex vivo kultivierten HPV-negativen Kopf-Hals-Karzinomen (Primarius und Lymphknotenmetastase)
Radiosensibilisierung durch duale Inhibition von Wee1 und PARP in ex vivo kultivierten HPV-negativen Kopf-Hals-Karzinomen (Primarius und Lymphknotenmetastase) Open
Einleitung Eine kurativ intendierte primäre/adjuvante platin-basierte Radiochemotherapie ist insbesondere bei HPV-negativen (HPV-) und regionär metastasierten fortgeschrittenen Kopf-Hals-Karzinomen mit Tumorrezidiven verbunden. Um effizien…
View article: Hypoglossal Nerve Stimulation in Moderate to Severe Obstructive Sleep Apnea – the UKE Experience
Hypoglossal Nerve Stimulation in Moderate to Severe Obstructive Sleep Apnea – the UKE Experience Open
Obstructive sleep apnea (OSA) refers tot the recurrent obstruction of the upper airways, especially of the pharynx, while asleep. The therapeutic approach is primarily of conservative nature, i.e. PAP ventilation during nighttime. In the e…
View article: Comparison between the electrostimulation parameters for a pacemaker to smile in facial paralysis and to adduct vocal fold in recurrent laryngeal nerve paresis
Comparison between the electrostimulation parameters for a pacemaker to smile in facial paralysis and to adduct vocal fold in recurrent laryngeal nerve paresis Open
Background Static surgeries, such as medialization laryngoplasty for vocal fold paresis (UVFP) or sling techniques for facial paralysis (FP) are limited to one position. Reinnervation surgeries may reduce this limitation, but require long …
View article: Postoperative Vitalitätskontrolle von Lappentransplantaten mittels Hyperspektraler Bildgebung
Postoperative Vitalitätskontrolle von Lappentransplantaten mittels Hyperspektraler Bildgebung Open
Einleitung In der Rekonstruktion von Gewebedefekten im Kopf-Hals Bereich mittels freien und gestielten Lappenplastiken ist ein postoperatives Monitoring zur Vitalitätskontrolle essenziell. Üblicherweise wird dies durch visuelle Kontrollen,…
View article: Operating time shortening via two-incision approach for upper airway stimulation
Operating time shortening via two-incision approach for upper airway stimulation Open
Introduction The 2-incision surgical technique for the Upper Airway Stimulation (Inspire) unilateral hypoglossal nerve stimulator was CE-certified in May 2021 and has been the standard approach since then. The conventional 3-incision techn…
View article: OP-Zeit-Verkürzung durch Zwei-Inzisions-Technik der Upper Airway Stimulation
OP-Zeit-Verkürzung durch Zwei-Inzisions-Technik der Upper Airway Stimulation Open
Einleitung Die 2-Inzisions-OP-Technik für den unilateralen, atmungsgesteuerten Zungenschrittmacher "Upper Airway Stimulation" (Inspire) wurde im Mai 2021 CE-zertifiziert und ist seither der Standardzugang. Die konventionelle 3-Inzisionstec…
View article: Evaluation of the influence of lymphnode burden/nodal yield and lymphnode density as prognostic markers of neck dissections on the outcome in patients with total laryngectomy
Evaluation of the influence of lymphnode burden/nodal yield and lymphnode density as prognostic markers of neck dissections on the outcome in patients with total laryngectomy Open
Background Controversies exist in regard to surgical neck management in total laryngectomies (TL). International guidelines do not sufficiently discriminate neck sides and sublevels, or minimal neck-dissection nodal yield (NY). The lymph n…
View article: Radiosensitization through dual inhibition of Wee1 and PARP in ex vivo cultivated HPV-negative head and neck carcinomas (primary and lymph node metastasis)
Radiosensitization through dual inhibition of Wee1 and PARP in ex vivo cultivated HPV-negative head and neck carcinomas (primary and lymph node metastasis) Open
Introduction Tumor relapse and recurrence are frequent after primary/adjuvant platinum-based chemotherapy of advanced head and neck cancer, especially when tumors are HPV-negative and present lymph node metastasis. In order to test more ef…
View article: Hypoglossus-Stimulation bei mittel- bis schwergradiger obstruktiver Schlafapnoe – UKE-Erfahrungen
Hypoglossus-Stimulation bei mittel- bis schwergradiger obstruktiver Schlafapnoe – UKE-Erfahrungen Open
Einleitung Die obstruktive Schlafapnoe (OSA) beschreibt nächtlich rezidivierende Obstruktionen der oberen Atemwege, insbesondere des Pharynx. Die Therapie erfolgt vorrangig konservativ durch nächtliche PAP-Beatmung. Bei Non-Adhärenz oder S…
View article: Postoperative flap monitoring using Hyperspectral Imaging – A case series
Postoperative flap monitoring using Hyperspectral Imaging – A case series Open
Introduction The free and pedicled flap reconstruction for defects of the head and neck demands a postoperative flap monitoring routine. This task is usually performed by visual examination of the flap, doppler sonography and pinpricking. …
View article: Vergleich der Elektrostimulationsparameter für einen implantierbaren Schrittmacher zum Lächeln bei Fazialisparalyse und für die Stimmlippenadduktion bei einseitiger Parese
Vergleich der Elektrostimulationsparameter für einen implantierbaren Schrittmacher zum Lächeln bei Fazialisparalyse und für die Stimmlippenadduktion bei einseitiger Parese Open
Hintergrund Statische Chirurgie, wie Medialisierungslaryngoplastiken bei Stimmlippenlähmung (UVFP) oder Zügelplastiken bei Fazialisparalyse (FP) ermöglichen nur eine Position. Reinnervations-Operationen sind langfristig meist besser, brauc…
View article: Bezold’s abscess and Lemierre’s syndrome after acute exacerbation of a chronic otitis media – A rare but severe complication.
Bezold’s abscess and Lemierre’s syndrome after acute exacerbation of a chronic otitis media – A rare but severe complication. Open
Introduction Bezold’s abscess is a rare complication of an acute otitis media caused by pus drainage through the medial mastoid process wall and digastric groove. Expansion of purulent secretion can lead to infectious thrombophlebitis of t…
View article: A Four-Generational Report on Hereditary Head and Neck Paraganglioma
A Four-Generational Report on Hereditary Head and Neck Paraganglioma Open